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Cited by 52Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityStress Responses and Cortisol

Inflammation as an Intermediate Pathway in the Association between Psychosocial Stress and Obesity

Hamer, Mark, Stamatakis, Emmanual·2008·Physiology & Behavior
DOI 10.1016/j.physbeh.2008.03.010
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Abstract

Psychosocial stress is associated with risk of obesity although little is known about stress-induced biological mechanisms of obesity. We examined the potential mediating role of inflammatory processes. Data were collected from a nationally representative sample of 7540 individuals (54% women, mean age 46.8+/-15.4 years), from the Scottish Health Surveys. We calculated risk estimates of obesity for increasing numbers of psychosocial stressors (based on social position, education, psychological distress and marital/partner discord) using logistic regression analyses. Obesity was assessed using body mass index and central obesity using waist circumference. Potential mediators included inflammatory markers (C-reactive protein and fibrinogen) and health behaviours (physical activity, smoking, alcohol, and dietary intake). The unadjusted odds ratio of obesity for three or more psychosocial stressors was 1.81 (95% CI, 1.39-2.36, p<0.001). In multivariate analyses that adjusted for age, gender, health behaviours and inflammatory markers the association between psychosocial stress and obesity was attenuated but remained significant (1.49, 1.11-2.00, p<0.001). Inflammatory markers independently accounted for approximately 25% of the association between stress and obesity. We found similar associations in separate analyses of psychosocial stress and central obesity, although results were confounded by overall obesity. In summary, inflammatory processes appear to be an important intermediate pathway in the association between psychosocial stress and obesity.

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  • HLA-B27-positive profile has already been associated with acute anterior uveitis.

    “Risk factors implicated in inflammation might comprise smoking, central adiposity, as well as HLA-B27-positive profile which has already been associated with acute anterior uveitis [136,137].”

    From Risk mitigation of immunogenicity: a key to personalized retinal gene therapy (2021) · cites this paper as [136]

  • Risk factors implicated in inflammation might comprise smoking, central adiposity, and HLA-B27-positive profile.

    “Risk factors implicated in inflammation might comprise smoking, central adiposity, as well as HLA-B27-positive profile which has already been associated with acute anterior uveitis [136,137].”

    From Risk mitigation of immunogenicity: a key to personalized retinal gene therapy (2021) · cites this paper as [136]

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Authors
Hamer, M., & Stamatakis, E.
Affiliations
University College London (GB)
Corresponding author
Hamer, Mark
ORCID
Hamer, Mark
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2008-07
Volume
94
Issue
4
Pages
536-539
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2008.03.010
OpenAlex
W1993840728
Cited by
52
References
37
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 3
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • British Heart Foundation
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
psychosocial stress, obesity, inflammation, C-reactive protein, fibrinogen, mediation, abdominal obesity, psychological distress, marital conflict, social status, health behavior, physical activity, smoking, alcohol consumption, dietary intake
MeSH terms
Adult, Aged, C-Reactive Protein, Female, Health Status, Health Surveys, Humans, Inflammation, Male, Middle Aged, Obesity, Reference Values, Regression Analysis, Scotland, Socioeconomic Factors, Stress, Psychological, Prevalence, Logistic Models, Case-Control Studies, Risk Assessment

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