Effects of sleep restriction on the human plasma metabolome
Open accessAbstract
This study examined the effects of recurrent sleep restriction on the plasma metabolome of adults with familial risk of type 2 diabetes. Eleven healthy adults (6M/5F; mean [SD] age: 26 [3]years; BMI 23.5 [2.3]kg/m(2)) with parental history of type 2 diabetes participated in a two-condition, two-period randomized crossover study at the Clinical Resource Center at an academic hospital. Each participant completed two 8-night inpatient sessions with restricted (5.5-h time-in-bed) vs. adequate (8.5-h time-in-bed) sleep opportunity while daily food intake and physical activity were carefully controlled. A combination of two UHPLC/MS/MS platforms and one GC/MS platform was used to measure 362 biochemicals in fasting plasma samples collected from study participants the morning after each 8-night sleep treatment. Relative concentrations of 12 amino acids and related metabolites were increased when sleep was curtailed. Sleep restriction also induced elevations in several fatty acid, bile acid, steroid hormone, and tricarboxylic acid cycle intermediates. In contrast, circulating levels of glucose, some monosaccharides, gluconate, and five-carbon sugar alcohols tended to decline when sleep was reduced. Recurrent sleep curtailment affected multiple pathways of intermediary metabolism in adults at risk for type 2 diabetes. An elevation in plasma amino acids and related biochemicals was the most pronounced metabolic signature seen in response to 8 nights of sleep restriction.
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Investigation of the human plasma metabolome suggests that amino acid metabolism is particularly perturbed as a function of sleep restriction.
“Investigation of the human plasma metabolome suggests that amino acid metabolism is particularly perturbed as a function of SR (26).”
From Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt (2015) · cites this paper as [26]
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Les acides aminés branchés, un lien « essentiel » entre alimentation, horloge et sommeil ?
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Metabolomics in sleep disorders
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Body-weight-specific and shared metabolomic responses to acute sleep loss in young adults
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- Authors
- Bell, L. N., Kilkus, J. M., Booth, J. N., Bromley, L. E., Imperial, J. G., & Penev, P. D.
- Affiliations
- Metabolon (United States) (US)
- University of Chicago (US)
- Corresponding author
- Kilkus, Jennifer M.
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 122
- Pages
- 25-31
- ISSN
- 0031-9384 (ISSN-L)
- PMC
- PMC3840107
- OpenAlex
- W2068826606
- Cited by
- 67
- References
- 31
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 10 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 6
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01-HL089637, CTSA-RR024999, P60-DK020595)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep restriction, plasma metabolome, type 2 diabetes risk, amino acids, fatty acids, bile acids, steroid hormones, tricarboxylic acid cycle intermediates, glucose, monosaccharides, sugar alcohols, gluconate, sleep duration
- MeSH terms
- Adult, Blood Glucose, Female, Humans, Insulin, Male, Sleep, Sleep Deprivation, Lipid Metabolism, Tandem Mass Spectrometry, Metabolome
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