Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans
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Simulated shift work uncovers potential tissue mechanisms for metabolic effects attributed to sleep loss and circadian disruption.
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One night of total sleep deprivation in healthy young males produced a catabolic gene signature in skeletal muscle.
“These findings were paralleled by a human study reporting a catabolic gene signature in skeletal muscle following one night of total sleep deprivation in healthy young males (Cedernaes et al., 2018).”
From The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment (2021) · cites this paper as Cedernaes et al., 2018
Acute and chronic sleep loss alter anabolic and catabolic hormone secretion patterns in humans.
“Experimental evidence suggests that acute and chronic sleep loss alter anabolic (Leproult & Van Cauter, 2011; Reynolds et al., 2012) and catabolic (Cedernaes et al., 2018; Dáttilo et al., 2020) hormone secretion patterns in humans.”
From The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment (2021) · cites this paper as Cedernaes et al., 2018
One night of sleep deprivation leads to a reduction in glucose tolerance.
“One night of sleep deprivation (commonly experienced by 20% of the world's population who perform shift-work) leads to a reduction in glucose tolerance and concomitant alterations in the expression of skeletal muscle clock genes (i.e., Bmal1 and Cry1 gene expression [7]) and the content of clock proteins (i.e., BMAL1) [8]”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [8]
The detrimental effect of sleep loss on glucose metabolism may also be associated with misalignment of circadian rhythms.
“The detrimental effect of sleep loss on glucose metabolism may also be associated with the misalignment of circadian rhythms [7,8].”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [8]
One night of sleep deprivation leads to concomitant alterations in expression of skeletal muscle clock genes (Bmal1 and Cry1) and content of clock proteins (BMAL1).
“One night of sleep deprivation (commonly experienced by 20% of the world's population who perform shift-work) leads to a reduction in glucose tolerance and concomitant alterations in the expression of skeletal muscle clock genes (i.e., Bmal1 and Cry1 gene expression [7]) and the content of clock proteins (i.e., BMAL1) [8]”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [8]
Our findings mirror those from Cedernaes et al. who reported no significant change in Glut4 mRNA or GLUT4 protein following one night of total sleep deprivation.
“Our findings mirror those from Cedernaes et al. [8], who reported no significant change in Glut4 mRNA or GLUT4 protein following one night of total sleep deprivation.”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [8]
Molecular markers of circadian rhythm are altered by a night of sleep deprivation.
“As many of the molecular processes that regulate mitochondrial content, function, and dynamics are regulated in a circadian manner [60,61] and considering that molecular markers of circadian rhythm are altered by a night of sleep deprivation [7,8], we also examined aspects of diurnal rhythmicity using the measures of peripheral skin temperature (obtained over 48 h, pre- and post-intervention) and”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [8]
Cedernaes et al. reported a decrease in Bmal1 mRNA expression in 15 participants following 24 h of sleep deprivation.
“This is in contrast to previous findings from Cedernaes et al. [7,8] who reported a decrease in Bmal1 mRNA expression in 15 participants following 24 h of sleep deprivation.”
From Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms (2021) · cites this paper as [8]
DNA methylation is an important determinant of epigenetic change and regulates tissue-specific expression of genes described recently in adipose tissue after one night of sleep loss.
“For example, DNA methylation, an important determinant of epigenetic change regulates tissue‐specific expression of genes described recently in adipose tissue after one night of sleep loss 56.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [56]
These epigenetic changes in DNA methylation in clock genes only occur in conditions like obesity and T2DM.
“This only occurs in conditions like obesity and T2DM.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [56]
A recent study demonstrated epigenetic changes in DNA methylation in clock genes.
“A recent study by Cedernaes et al. 56 demonstrated epigenetic changes in DNA methylation in the clock genes.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [56]
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The Circadian Syndrome: is the Metabolic Syndrome and much more!
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Sleep, Autonomic Nervous Function and Atherosclerosis
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Sleep characteristics and HbA1c in patients with type 2 diabetes on glucose-lowering medication
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Sleep duration and fragmentation in relation to leukocyte DNA methylation in adolescents
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Sleep and Injury in the Young Athlete
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Epigenetic Changes Associated With Obesity-related Metabolic Comorbidities
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Dynamic DNA methylation modifications in the cold stress response of cassava
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Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation
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A Role for Exercise to Counter Skeletal Muscle Clock Disruption
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Sleep quality traits correlate with inflammatory markers in the breast tissue of women
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Sleep Duration and Visceral Adipose Tissue: Linear and Nonlinear Mendelian Randomization Analyses
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The mitoepigenome responds to stress, suggesting novel mito-nuclear interactions in vertebrates
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regionalpcs improve discovery of DNA methylation associations with complex traits
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Chronotherapeutic effect of orexin antagonists on glucose metabolism in diabetic mice
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Circadian-driven tissue specificity is constrained under caloric restricted feeding conditions
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Bedürfnisbefriedigung durch Essen und Trinken
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Epigenetics of Sleep Disruption
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- Authors
- Cedernaes, J., Schönke, M., Westholm, J. O., Mi, J., Chibalin, A., Voisin, S., Osler, M., Vogel, H., Hörnaeus, K., Dickson, S. L., Lind, S. B., Bergquist, J., Schiöth, H. B., Zierath, J. R., & Benedict, C.
- Affiliations
- Uppsala University (SE)
- Karolinska Institutet (SE)
- Stockholm University (SE)
- German Institute of Human Nutrition (DE)
- University of Gothenburg (SE)
- Corresponding author
- Cedernaes, Jonathan
- Schönke, Milena
- Westholm, Jakub Orzechowski
- ORCID
- Venue
- Science Advances
- Published
- 2018-08-03
- Volume
- 4
- Issue
- 8
- Pages
- eaar8590-eaar8590
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC6105229
- OpenAlex
- W2888269462
- Cited by
- 137
- References
- 85
- Citations by year
- 2026: 14 · 2025: 21 · 2024: 17 · 2023: 12 · 2022: 20 · 2021: 18 · 2020: 19 · 2019: 14 · 2018: 2
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion, cc-by-nc)
- Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
- Funders
- Swedish Research Council Formas (2014-6888)
- Swedish Research Council for Health, Working Life and Welfare (2015-03100)
- Swedish Society of Medicine (SLS-694111)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- DNA methylation, adipose tissue, skeletal muscle, circadian clock, inflammation, muscle breakdown, sarcopenia, weight gain, blood metabolites, transcriptome, circadian rhythm disruption
- MeSH terms
- Adult, Circadian Rhythm, Humans, Male, Sleep, Muscle, Skeletal, Cross-Over Studies, DNA Methylation, Epigenesis, Genetic, Metabolic Networks and Pathways, Metabolomics, Young Adult, Circadian Clocks, Transcriptome
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