Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain

Afzalpour, Mohammad Esmaiel; Chadorneshin, Hossein Taheri; Foadoddini, Mohsen; Eivari, Hossein Abtahi

doi:10.1016/j.physbeh.2015.04.012

Cited by 131Exercise and Physiological ResponsesNerve injury and regenerationCardiovascular and exercise physiology

Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain

Afzalpour, Mohammad Esmaiel, Chadorneshin, Hossein Taheri, Foadoddini, Mohsen, Eivari, Hossein Abtahi·2015·Physiology & Behavior

DOI 10.1016/j.physbeh.2015.04.012

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Abstract

The research literature suggests that oxidative stress and pro-inflammatory factors influence neurotrophins in vitro. However, there is insufficient information about their effects on exercise training conditions, especially during high intensity trainings. This study aimed to compare the effects of 6weeks of high intensity interval and continuous training regimens on brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), hydrogen peroxide (H2O2), and tumor necrosis factor alpha (TNF-α) in the rat brain. For this purpose, twenty-four Albino Wistar rats were divided into sedentary control (SC), high intensity interval training (HIIT), and continuous training (CT) groups. Both HIIT and CT regimens increased H2O2 level and TNF-α concentration in the brain, and the alterations made were greater following HIIT than CT. In addition, both HIIT and CT regimens increased BDNF and GDNF concentrations significantly, with a higher elevation following HIIT than CT. Furthermore, H2O2 level and TNF-α concentration correlated positively with both BDNF and GDNF concentrations. Generally, high intensity interval training regimen, rather than continuous training regimen, is highly potential to improve BDNF and GDNF through a greater increase in H2O2 and TNF-α as oxidative stress and pro-inflammatory factors.

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Treatment with Ecdy in three dosages (1, 10, 100 mg/kg/day), especially the higher dosage for 12 weeks, orally reversed conditions caused by type 1 diabetes in rats.
“the treatment with Ecdy in three dosages (1,10,100 mg/kg/day), especially in higher dosage for 12 weeks, orally reversed the conditions mentioned above caused by diabetes (33).”
From Effects of the combination of high-intensity interval training and Ecdysterone on learning and memory abilities, antioxidant enzyme activities, and neuronal population in an Amyloid-beta-induced rat model of Alzheimer’s disease (2022) · cites this paper as [33]

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Authors: Afzalpour, M. E., Chadorneshin, H. T., Foadoddini, M., & Eivari, H. A.
Affiliations: University of Birjand (IR)
Birjand University of Medical Sciences (IR)
Gonabad University of Medical Sciences (IR)
ORCID: Foadoddini, Mohsen
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 2015-08
Volume: 147
Pages: 78-83
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/j.physbeh.2015.04.012
OpenAlex: W2058551342
Cited by: 131
References: 41
Citations by year: 2026: 5 · 2025: 10 · 2024: 6 · 2023: 13 · 2022: 15 · 2021: 13 · 2020: 13 · 2019: 22 · 2018: 13 · 2017: 10 · 2016: 7 · 2015: 4
FWCI: 11.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: high-intensity interval training, continuous training, exercise training, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, oxidative stress, hydrogen peroxide, TNF-α, neuroinflammation, rat brain, neurotrophic factors
MeSH terms: Animals, Body Weight, Brain, Hydrogen Peroxide, Male, Nerve Growth Factors, Physical Conditioning, Animal, Time Factors, Rats, Wistar, Statistics, Nonparametric, Rats

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Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain

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