The effects of physical exercise and cognitive training on memory and neurotrophic factors.
Abstract
This study examined the combined effect of physical exercise and cognitive training on memory and neurotrophic factors in healthy, young adults. Ninety-five participants completed 6 weeks of exercise training, combined exercise and cognitive training, or no training (control). Both the exercise and combined training groups improved performance on a high-interference memory task, whereas the control group did not. In contrast, neither training group improved on general recognition performance, suggesting that exercise training selectively increases high-interference memory that may be linked to hippocampal function. Individuals who experienced greater fitness improvements from the exercise training (i.e., high responders to exercise) also had greater increases in the serum neurotrophic factors brain-derived neurotrophic factor and insulin-like growth factor-1. These high responders to exercise also had better high-interference memory performance as a result of the combined exercise and cognitive training compared with exercise alone, suggesting that potential synergistic effects might depend on the availability of neurotrophic factors. These findings are especially important, as memory benefits accrued from a relatively short intervention in high-functioning young adults.
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After 6 weeks of high-intensity endurance training, responders who improved their CRF to a greater extent than non-responders exhibited a significantly higher increase in serum BDNF.
“For instance, after 6 weeks of high-intensity endurance training, responders who improved their CRF [assessed via peak oxygen uptake (VO2 peak)] to a greater extent than non-responders exhibited a significantly higher increase in serum BDNF (Heisz et al., 2017).”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Heisz et al., 2017
Interindividual differences in response to endurance training affect the expression of neurotrophic factors such as brain-derived neurotrophic factor.
“Such interindividual differences in response to endurance training also affect the expression of neurotrophic factors [e.g., brain-derived neurotrophic factor (BDNF)] (Heisz et al., 2017)”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Heisz et al., 2017
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Haverkamp, B. F., Wiersma, R., Vertessen, K., van Ewijk, H., Oosterlaan, J., & Hartman, E. (2020) · Journal of Sports Sciences · doi:10.1080/02640414.2020.1794763 · Cited by 238 · see citing works
“, 2016) investigated the effects of acute physical activity interventions, and 27 studies (Ardoy et al., 2014; Butzer et al., 2015; Costigan et al., 2016; Duarte et al., 2020; Hagins & Rundle, 2016; Heisz et al., 2017; Jeon & Ha, 2017; Johann et al., 2016; Kauts & Sharma, 2009; Lennemann et al., 2013; Ludyga, Gerber,…”
BackgroundLactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241 · see citing works
Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research
Herold, F., Müller, P., Gronwald, T., & Müller, N. G. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02338 · Cited by 196 · see citing works
Bell, K. E., Fang, H., Snijders, T., Allison, D. J., Zulyniak, M. A., Chabowski, A., Parise, G., Phillips, S. M., & Heisz, J. J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00107 · Cited by 29 · see citing works
Putative neural consequences of captivity for elephants and cetaceans
Jacobs, B., Rally, H., Doyle, C., O’Brien, L., Tennison, M., & Marino, L. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0100 · Cited by 25 · see citing works
- Authors
- Heisz, J. J., Clark, I. B., Bonin, K., Paolucci, E. M., Michalski, B., Becker, S., & Fahnestock, M.
- Affiliations
- McMaster University (CA)
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press
- Published
- 2017-11-01
- Volume
- 29
- Issue
- 11
- Pages
- 1895-1907
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W2734585321
- Cited by
- 144
- References
- 111
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 16 · 2023: 24 · 2022: 19 · 2021: 14 · 2020: 21 · 2019: 21 · 2018: 7 · 2017: 1
- FWCI
- 17.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- physical activity, cognitive training, memory, neurotrophic factors, brain-derived neurotrophic factor, insulin-like growth factor I, recognition memory, hippocampal function, young adults
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Cognition, Female, Humans, Individuality, Insulin-Like Growth Factor I, Male, Memory, Neuropsychological Tests, Teaching, Exercise, Brain-Derived Neurotrophic Factor, Young Adult
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