Dietary Combination of Fucoxanthin and Fish Oil Attenuates the Weight Gain of White Adipose Tissue and Decreases Blood Glucose in Obese/Diabetic KK-Ay Mice
Abstract
Fucoxanthin is a marine carotenoid found in edible brown seaweeds. We previously reported that dietary fucoxanthin attenuates the weight gain of white adipose tissue (WAT) of diabetic/obese KK- A(y) mice. In this study, to evaluate the antiobesity and antidiabetic effects of fucoxanthin and fish oil, we investigated the effect on the WAT weight, blood glucose, and insulin levels of KK- A(y) mice. Furthermore, the expression level of uncoupling protein 1 (UCP1) and adipokine mRNA in WAT were measured. After 4 weeks of feeding, 0.2% fucoxanthin in the diet markedly attenuated the gain of WAT weight in KK- A(y) mice with increasing UCP1 expression compared with the control mice. The WAT weight of the mice fed 0.1% fucoxanthin and 6.9% fish oil was also significantly lower than that of the mice fed fucoxanthin alone. In addition, 0.2% fucoxanthin markedly decreased the blood glucose and plasma insulin concentrations in KK- A(y) mice. The mice fed with the combination diet of 0.1% fucoxanthin and fish oil also showed improvements similar to that of 0.2% fucoxanthin. Leptin and tumor necrosis factor (TNFalpha) mRNA expression in WAT were significantly down-regulated by 0.2% fucoxanthin. These results suggest that dietary fucoxanthin decreases the blood glucose and plasma insulin concentration of KK- A(y) along with down-regulating TNFalpha mRNA. In addition, the combination of fucoxanthin and fish oil is more effective for attenuating the weight gain of WAT than feeding with fucoxanthin alone.
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From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [253]
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- Authors
- Maeda, H., Hosokawa, M., Sashima, T., & Miyashita, K.
- Affiliations
- Hokkaido University (JP)
- Corresponding author
- Hosokawa, Masashi
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-08-23
- Volume
- 55
- Issue
- 19
- Pages
- 7701-7706
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2014076063
- Cited by
- 319
- References
- 32
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 12 · 2023: 14 · 2022: 22 · 2021: 19 · 2020: 24 · 2019: 20 · 2018: 17 · 2017: 23 · 2016: 13 · 2015: 26 · 2014: 17 · 2013: 20 · 2012: 22
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- fucoxanthin, fish oil, white adipose tissue, obesity, type 2 diabetes, KK-Ay mice, UCP1, blood glucose, insulin, leptin, TNF-α, adipokines, anti-obesity, antidiabetic effect
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Diabetes Mellitus, Diet, Female, Fish Oils, Mice, Obese, Obesity, Weight Gain, Xanthophylls, Mice
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