Suppressive Effect of Neoxanthin on the Differentiation of 3T3-L1 Adipose Cells
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The objective of this study was to assess the suppressive effects of 13 naturally occurring carotenoids on the adipocyte differentiation of 3T3-L1. The relationship between carotenoid structure and suppressive effects was also examined. Treatment with neoxanthin significantly reduced lipid accumulation, as well as glycerol-3-phosphate dehydrogenase activity. This suppressive effect on adipose cell differentiation was not observed in the other 12 carotenoids used in this study. Neoxanthin treatment also decreased expression of CCAAT/enhancer binding protein alpha (C/EBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma) mRNAs. An examination of structure and function suggested that carotenoids containing an allene bond and an additional hydroxyl substituent on the side group may show suppressive effects on adipocyte differentiation in 3T3-L1 cells.
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Neoxanthin and fucoxanthin inhibit the accumulation of fats, and allenic and hydroxyl groups must be present to differentiate adipocytes.
“Okada et al. [252] reported that neoxanthin and fucoxanthin inhibited the accumulation of fats and stated that allenic and hydroxyl groups must be present to differentiate adipocytes.”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [252]
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Shaaban, H. A., Abdel-Gawad, H. H., & Sleem, M. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-75322-0_10 · Cited by 2 · see citing works
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Effects of Carotenoids on 3T3-L1 Preadipocyte Viability and Differentiation
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Effect of cellular folate availability on adipocyte life cycle and metabolism
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Green Chemicals From Microalgae
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- Authors
- Okada, T., Nakai, M., Maeda, H., Hosokawa, M., Sashima, T., & Miyashita, K.
- Affiliations
- Hokkaido University (JP)
- Venue
- Journal of Oleo Science
- Publisher
- Japan Oil Chemists' Society
- Published
- 2008
- Volume
- 57
- Issue
- 6
- Pages
- 345-351
- ISSN
- 1341-8327 (ISSN-L)
- 1345-8957
- 1347-3352
- OpenAlex
- W2165966447
- Cited by
- 98
- References
- 23
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 9 · 2022: 4 · 2021: 6 · 2020: 11 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 5
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Oleo Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Bio-oriented Technology Research Advancement Institution
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- neoxanthin, carotenoids, adipogenesis, 3T3-L1 cells, lipid accumulation, glycerol-3-phosphate dehydrogenase, C/EBPα, PPARγ, structure-activity relationship, hydroxyl substituents, anti-adipogenic effect
- MeSH terms
- Adipose Tissue, Animals, Azo Compounds, Carotenoids, Cell Differentiation, Dose-Response Relationship, Drug, Glycerolphosphate Dehydrogenase, Models, Chemical, Adipocytes, Anti-Obesity Agents, CCAAT-Enhancer-Binding Protein-alpha, Xanthophylls, 3T3-L1 Cells, PPAR gamma, Mice
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