Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation
Open accessAbstract
Microglia are crucial for brain homeostasis, and dysfunction of these cells is a key driver in most neurodegenerative diseases, including peroxisomal leukodystrophies. In X-linked adrenoleukodystrophy (X-ALD), a neuroinflammatory disorder, very long-chain fatty acid (VLCFA) accumulation due to impaired degradation within peroxisomes results in microglial defects, but the underlying mechanisms remain unclear. Using CRISPR/Cas9 gene editing of key genes in peroxisomal VLCFA breakdown ( Abcd1, Abcd2 , and Acox1 ), we recently established easily accessible microglial BV-2 cell models to study the impact of dysfunctional peroxisomal β-oxidation and revealed a disease-associated microglial-like signature in these cell lines. Transcriptomic analysis suggested consequences on the immune response. To clarify how impaired lipid degradation impacts the immune function of microglia, we here used RNA-sequencing and functional assays related to the immune response to compare wild-type and mutant BV-2 cell lines under basal conditions and upon pro-inflammatory lipopolysaccharide (LPS) activation. A majority of genes encoding proinflammatory cytokines, as well as genes involved in phagocytosis, antigen presentation, and co-stimulation of T lymphocytes, were found differentially overexpressed. The transcriptomic alterations were reflected by altered phagocytic capacity, inflammasome activation, increased release of inflammatory cytokines, including TNF, and upregulated response of T lymphocytes primed by mutant BV-2 cells presenting peptides. Together, the present study shows that peroxisomal β-oxidation defects resulting in lipid alterations, including VLCFA accumulation, directly reprogram the main cellular functions of microglia. The elucidation of this link between lipid metabolism and the immune response of microglia will help to better understand the pathogenesis of peroxisomal leukodystrophies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Following LPS exposure, ABCD1-mutated microglia had numerous differentially expressed genes encoding pro-inflammatory cytokines or involved in phagocytosis, antigen presentation, and co-stimulation of T lymphocytes.
“Following LPS exposure, the ABCD1-mutated microglia had numerous differentially expressed genes encoding pro-inflammatory cytokines or involved in phagocytosis, antigen presentation, and co-stimulation of T lymphocytes.”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [352]
The Results sections on LPS response, phagocytosis, and antigen presentation report differentially expressed genes in all the categories named. However, the tested ABCD1-deficient cells were murine BV-2 cells with both Abcd1 and Abcd2 knocked out; the claim omits the Abcd2 mutation and could be read as applying to ABCD1 mutation alone. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288 · see citing works
ShinyGO: a graphical gene-set enrichment tool for animals and plants
Ge, S. X., Jung, D., & Yao, R. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btz931 · Cited by 5,270 · see citing works
Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979 · see citing works
Heatmapper: web-enabled heat mapping for all
Babicki, S., Arndt, D., Marcu, A., Liang, Y., Grant, J., Maciejewski, A., & Wishart, D. (2016) · Nucleic Acids Res. · doi:10.1093/nar/gkw419 · Cited by 2,119 · see citing works
Microglia states and nomenclature: A field at its crossroads
Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.020 · Cited by 1,973 · see citing works
Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy
Cartier, N., Hacein-Bey-Abina, S., Bartholomae, C. C., Veres, G., Schmidt, M., Kutschera, I., Vidaud, M., Abel, U., Dal-Cortivo, L., Caccavelli, L., et al. (2009) · Science · doi:10.1126/science.1171242 · Cited by 1,508 · see citing works
MYELINATION IN RAT BRAIN: METHOD OF MYELIN ISOLATION<sup>1</sup>
Norton, W. T., & Poduslo, S. E. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb07519.x · Cited by 1,413 · see citing works
Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
Mosser, J., Douar, A.-M., Sarde, C.-O., Kioschis, P., Feil, R., Moser, H., Poustka, A.-M., Mandel, J.-L., & Aubourg, P. (1993) · Nature · doi:10.1038/361726a0 · Cited by 1,202 · see citing works
Microglial priming in neurodegenerative disease
Perry, V. H., & Holmes, C. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.38 · Cited by 1,127 · see citing works
Review: microglia of the aged brain: primed to be activated and resistant to regulation
Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works
TREM2 — a key player in microglial biology and Alzheimer disease
Ulland, T. K., & Colonna, M. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0072-1 · Cited by 735 · see citing works
Lehnardt, S., Lachance, C., Patrizi, S., Lefebvre, S., Follett, P. L., Jensen, F. E., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02478.2002 · Cited by 684 · see citing works
Phagocytosis of Microglia in the Central Nervous System Diseases
Fu, R., Shen, Q., Xu, P., Luo, J. J., & Tang, Y. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8620-6 · Cited by 646 · see citing works
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., et al. (2023) · Nature · doi:10.1038/s41586-023-05788-0 · Cited by 609 · see citing works
Hematopoietic stem-cell gene therapy for cerebral adrenoleukodystrophy
Eichler, F., Duncan, C., Musolino, P. L., Orchard, P. J., De Oliveira, S., Thrasher, A. J., Armant, M., Dansereau, C., Lund, T. C., Miller, W. P., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1700554 · Cited by 604 · see citing works
Inflammatory Response in the CNS: Friend or Foe?
Sochocka, M., Diniz, B. S., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0297-1 · Cited by 573 · see citing works
New insights into the role of TREM2 in Alzheimer’s disease
Gratuze, M., Leyns, C. E. G., & Holtzman, D. M. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0298-9 · Cited by 489 · see citing works
TREM2 in Neurodegenerative Diseases
Jay, T. R., von Saucken, V. E., & Landreth, G. E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0197-5 · Cited by 427 · see citing works
Cignarella, F., Filipello, F., Bollman, B., Cantoni, C., Locca, A., Mikesell, R., Manis, M., Ibrahim, A., Deng, L., Benitez, B. A., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02193-z · Cited by 392 · see citing works
The pro-remyelination properties of microglia in the central nervous system
Lloyd, A. F., & Miron, V. E. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0184-2 · Cited by 381 · see citing works
Neuroinflammation: Microglia and T Cells Get Ready to Tango
Schetters, S. T. T., Gómez‐Nicola, D., García-Vallejo, J. J., & van Kooyk, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01905 · Cited by 378 · see citing works
Montgomery, S. L., & Bowers, W. J. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9287-2 · Cited by 365 · see citing works
Toll-like receptors in the pathogenesis of neuroinflammation
Kumar, V. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.03.012 · Cited by 331 · see citing works
Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation
Lasserre, R., Guo, X., Conchonaud, F., Hamon, Y., Hawchar, O., Bernard, A., Soudja, S. M., Lenne, P., Rigneault, H., Olive, D., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.103 · Cited by 316 · see citing works
Self-citationPhagocytosis in the Brain: Homeostasis and Disease
Galloway, D. A., Phillips, A. E. M., Owen, D. R., & Moore, C. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00790 · Cited by 304 · see citing works
Casson, C. N., Yu, J. M., Reyes, V. M., Taschuk, F., Yadav, A., Copenhaver, A. M., Nguyen, H. T., Collman, R. G., & Shin, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421699112 · Cited by 276 · see citing works
Adrenoleukodystrophy—Neuroendocrine pathogenesis and redefinition of natural history
Kemp, S., Huffnagel, I. C., Linthorst, G. E., Wanders, R. J., & Engelen, M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.90 · Cited by 275 · see citing works
Hwang, D. H., Kim, J., & Lee, J. Y. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.04.024 · Cited by 240 · see citing works
The physiological functions of human peroxisomes
Wanders, R. J. A., Baes, M., Ribeiro, D., Ferdinandusse, S., & Waterham, H. R. (2023) · Physiological Reviews · doi:10.1152/physrev.00051.2021 · Cited by 228 · see citing works
Lombard-Platet, G., Savary, S., Sarde, C. O., Mandel, J. L., & Chimini, G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1265 · Cited by 222 · see citing works
Self-citationThe Role of GPNMB in Inflammation
Saade, M., Araujo de Souza, G., Scavone, C., & Kinoshita, P. F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674739 · Cited by 216 · see citing works
Lund, S., Christensen, K. V., Hedtjärn, M., Mortensen, A. L., Hagberg, H., Falsig, J., Hasseldam, H., Schrattenholz, A. S., Pörzgen, P., & Leist, M. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.07.007 · Cited by 212 · see citing works
Microglia as Dynamic Cellular Mediators of Brain Function
Wright-Jin, E. C., & Gutmann, D. H. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.08.013 · Cited by 186 · see citing works
CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation
Grajchen, E., Wouters, E., van de Haterd, B., Haidar, M., Hardonnière, K., Dierckx, T., Broeckhoven, J. V., Erens, C., Hendrix, S., Kerdine‐Römer, S., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01899-x · Cited by 183 · see citing works
Das, A., Kim, S. H., Arifuzzaman, S., Yoon, T., Chai, J. C., Lee, Y. S., Park, K. S., Jung, K. H., & Chai, Y. G. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0644-1 · Cited by 171 · see citing works
van der Laan, L. J. W., Ruuls, S. R., Weber, K. S., Lodder, I. J., Döpp, E. A., & Dijkstra, C. D. (1996) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00110-5 · Cited by 166 · see citing works
Haure-Mirande, J.-V., Audrain, M., Ehrlich, M. E., & Gandy, S. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00552-w · Cited by 159 · see citing works
Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency
Ferdinandusse, S., Denis, S., Hogenhout, E. M., Koster, J., van Roermund, C. W. T., IJlst, L., Moser, A. B., Wanders, R. J. A., & Waterham, H. R. (2007) · Human Mutation · doi:10.1002/humu.20535 · Cited by 156 · see citing works
Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation
Berglund, R., Guerreiro-Cacais, A. O., Adzemovic, M. Z., Zeitelhofer, M., Lund, H., Ewing, E., Ruhrmann, S., Nutma, E., Parsa, R., Thessen-Hedreul, M., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb5077 · Cited by 149 · see citing works
Berger, J., Wiesinger, C., & Eichler, F. (2015) · The Application of Clinical Genetics · doi:10.2147/tacg.s49590 · Cited by 140 · see citing works
Self-citationShen, K., Reichelt, M., Kyauk, R. V., Ngu, H., Shen, Y.-A. A., Foreman, O., Modrusan, Z., Friedman, B. A., Sheng, M., & Yuen, T. J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108835 · Cited by 138 · see citing works
Liu, Y., Hao, W., Letièmbre, M., Walter, S., Kulanga, M., Neumann, H., & Fassbender, K. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2531-06.2006 · Cited by 131 · see citing works
Peroxisomes in Immune Response and Inflammation
Cara, F. D., Andreoletti, P., Trompier, D., Véjux, A., Bülow, M. H., Sellin, J., Lizard, G., Cherkaoui‐Malki, M., & Savary, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163877 · Cited by 127 · see citing works
Self-citationRangaraju, S., Raza, S. A., Li, N. X., Betarbet, R., Dammer, E. B., Duong, D., Lah, J. J., Seyfried, N. T., & Levey, A. I. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00405 · Cited by 126 · see citing works
Ito, M., Blumberg, B. M., Mock, D. J., Goodman, A. D., Moser, A. B., Moser, H. W., Smith, K. D., & Powers, J. M. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.10.1004 · Cited by 125 · see citing works
Dai, X., Li, N., Yu, L., Chen, Z.-Y., Hua, R., Qin, X., & Zhang, Y.-M. (2014) · Cell Stress and Chaperones · doi:10.1007/s12192-014-0552-1 · Cited by 123 · see citing works
Paintlia, A. S., Gilg, A. G., Khan, M., Singh, A. K., Barbosa, E., & Singh, I. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.08.013 · Cited by 120 · see citing works
Reichert, F., & Rotshenker, S. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00008-6 · Cited by 119 · see citing works
Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis
Gaultier, A., Wu, X., Le Moan, N., Takimoto, S., Mukandala, G., Akassoglou, K., Campana, W. M., & Gonias, S. L. (2009) · Journal of Cell Science · doi:10.1242/jcs.040717 · Cited by 118 · see citing works
Cerebral adrenoleukodystrophy (ALD) in only one of monozygotic twins with an identical ALD genotype
Korenke, G. C., Wilichowski, E., Hunneman, D. H., Hanefeld, F., Fuchs, S., Krasemann, E., & Doerr, H. G. (1996) · Annals of Neurology · doi:10.1002/ana.410400221 · Cited by 117 · see citing works
The peroxisome: an up-and-coming organelle in immunometabolism
Cara, F. D., Savary, S., Kovacs, W. J., Kim, P., & Rachubinski, R. A. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.06.001 · Cited by 117 · see citing works
Self-citationBlouin, C. M., Hamon, Y., Gonnord, P., Boularan, C., Kagan, J., de Lesegno, C. V., Ruez, R., Mailfert, S., Bertaux, N., Loew, D., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.003 · Cited by 116 · see citing works
Self-citationThe Phagocytic Code Regulating Phagocytosis of Mammalian Cells
Cockram, T. O. J., Dundee, J. M., Popescu, A. S., & Brown, G. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629979 · Cited by 111 · see citing works
Griffin, D. E., Moser, H. W., Mendoza, Q. P., Moench, T. R., O'Toole, S., & Moser, A. B. (1985) · Annals of Neurology · doi:10.1002/ana.410180606 · Cited by 107 · see citing works
Larocca, J. N., & Norton, W. T. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0325s33 · Cited by 105 · see citing works
Microglial Priming as Trained Immunity in the Brain
Haley, M. J., Brough, D., Quintin, J., & Allan, S. M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.039 · Cited by 104 · see citing works
Bussi, C., Peralta Ramos, J. M., Arroyo, D. S., Gaviglio, E. A., Gallea, J. I., Wang, J. M., Celej, M. S., & Iribarren, P. (2017) · Scientific Reports · doi:10.1038/srep43153 · Cited by 103 · see citing works
Kong, F., Zhao, S.-J., Sun, P. G., Liu, H., Jian, J., Xu, T., Xu, A.-D., Yang, Y., Zhu, Y., Chen, J., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01735-2 · Cited by 103 · see citing works
Role of Chemokines in the Development and Progression of Alzheimer’s Disease
Wojcieszak, J., Kuczyńska, K., & Zawilska, J. B. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02047-1 · Cited by 97 · see citing works
Bergner, C. G., van der Meer, F., Winkler, A., Wrzos, C., Türkmen, M., Valizada, E., Fitzner, D., Hametner, S., Hartmann, C., Pfeifenbring, S., et al. (2019) · Glia · doi:10.1002/glia.23598 · Cited by 94 · see citing works
Regulation of Phagocytosis in Macrophages by Membrane Ethanolamine Plasmalogens
Rubio, J. M., Astudillo, A. M., Casas, J., Balboa, M. A., & Balsinde, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01723 · Cited by 91 · see citing works
Xu, Y., Li, Y., Wang, C., Han, T., Liu, H., Sun, L., Hong, J., Hashimoto, M., & Wei, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02723-y · Cited by 88 · see citing works
Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling
Li, Y., & Jiang, Q. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1128358 · Cited by 86 · see citing works
Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy.
Fournier, B., Saudubray, J., Bénichou, B., Lyonnet, S., Münnich, A., Clevers, H. C., & Poll‐The, B. T. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117365 · Cited by 83 · see citing works
Lu, Y., Zhao, L., Cao, D., & Gao, Y. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.03.003 · Cited by 77 · see citing works
Impaired plasticity of macrophages in X-linked adrenoleukodystrophy
Weinhofer, I., Zierfuss, B., Hametner, S., Wagner, M., Popitsch, N., Machacek, C., Bartolini, B., Zlabinger, G., Ohradanova-Repic, A., Stockinger, H., et al. (2018) · Brain · doi:10.1093/brain/awy127 · Cited by 72 · see citing works
Self-citationPeroxisomal ABC Transporters: An Update
Tawbeh, A., Gondcaille, C., Trompier, D., & Savary, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116093 · Cited by 68 · see citing works
Self-citationMerTK-mediated regulation of myelin phagocytosis by macrophages generated from patients with MS
Healy, L. M., Jang, J. H., Won, S., Lin, Y. H., Touil, H., Aljarallah, S., Bar‐Or, A., & Antel, J. P. (2017) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000402 · Cited by 63 · see citing works
T Cells: A Growing Universe of Roles in Neurodegenerative Diseases
Dressman, D., & Elyaman, W. (2021) · The Neuroscientist · doi:10.1177/10738584211024907 · Cited by 56 · see citing works
Tumor necrosis factor-α and X-linked adrenoleukodystrophy
McGuinness, M. C., Griffin, D. E., Raymond, G. V., Washington, C., Moser, H. W., & Smith, K. D. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00084-f · Cited by 54 · see citing works
Microglial dysfunction as a key pathological change in adrenomyeloneuropathy
Gong, Y., Sasidharan, N., Laheji, F., Frosch, M., Musolino, P., Tanzi, R., Kim, D. Y., Biffi, A., El Khoury, J., & Eichler, F. (2017) · Annals of Neurology · doi:10.1002/ana.25085 · Cited by 54 · see citing works
Toll‐like receptors in pathogenesis of neurodegenerative diseases and their therapeutic potential
Dabi, Y. T., Ajagbe͓, A. O., & Degechisa, S. T. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.839 · Cited by 54 · see citing works
A microglial cell model for acyl-CoA oxidase 1 deficiency
Raas, Q., Saih, F.-E., Gondcaille, C., Trompier, D., Hamon, Y., Leoni, V., Caccia, C., Nasser, B., Jadot, M., Ménétrier, F., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.10.005 · Cited by 54 · see citing works
Self-citationHammel, G., Zivkovic, S., Ayazi, M., & Ren, Y. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104591 · Cited by 53 · see citing works
Raas, Q., Gondcaille, C., Hamon, Y., Leoni, V., Caccia, C., Ménétrier, F., Lizard, G., Trompier, D., & Savary, S. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.02.006 · Cited by 53 · see citing works
Self-citationGenin, E. C., Geillon, F., Gondcaille, C., Athias, A., Gambert, P., Trompier, D., & Savary, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.211912 · Cited by 53 · see citing works
Self-citationKuhlmann, T., Wendling, U., Nolte, C., Zipp, F., Maruschak, B., Stadelmann, C., Siebert, H., & Brück, W. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10104 · Cited by 52 · see citing works
Role of metabolic programming in the modulation of microglia phagocytosis by lipids
Nadjar, A. (2018) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.07.006 · Cited by 49 · see citing works
Salles, A., Billaudeau, C., Sergé, A., Bernard, A., Phélipot, M.-C., Bertaux, N., Fallet, M., Grenot, P., Marguet, D., He, H., et al. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003245 · Cited by 49 · see citing works
Self-citationImmune Response in Leukodystrophies
Eichler, F., & van Haren, K. P. (2007) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2007.06.011 · Cited by 47 · see citing works
Das, A., Chai, J. C., Kim, S. H., Park, K. S., Lee, Y. S., Jung, K. H., & Chai, Y. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121117 · Cited by 47 · see citing works
Human IgM antibody rHIgM22 promotes phagocytic clearance of myelin debris by microglia
Zorina, Y., Stricker, J., Caggiano, A. O., & Button, D. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-27559-y · Cited by 43 · see citing works
Vamecq, J., Andreoletti, P., Kebbaj, R. E., Saih, F.-E., Latruffe, N., Kebbaj, M. S. E., Lizard, G., Nasser, B., & Cherkaoui‐Malki, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6986984 · Cited by 42 · see citing works
Self-citationLund, T. C., Stadem, P. S., Panoskaltsis‐Mortari, A., Raymond, G. V., Miller, W. P., Tolar, J., & Orchard, P. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032218 · Cited by 41 · see citing works
TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells
Xia, F., Qian, C., Xun, Z., Hamon, Y., Sartre, A.-M., Formisano, A., Mailfert, S., Phélipot, M.-C., Billaudeau, C., Jaeger, S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02864 · Cited by 38 · see citing works
Self-citationNöhammer, C., El‐Shabrawi, Y., Schauer, S., Hiden, M., Berger, J., Forss‐Petter, S., Winter, E., Eferl, R., Zechner, R., & Höefler, G. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01128.x · Cited by 38 · see citing works
Self-citationSaturated very long-chain fatty acids regulate macrophage plasticity and invasiveness
Zierfuss, B., Buda, A., Villoria-González, A., Logist, M., Fabjan, J., Parzer, P., Battin, C., Vandersteene, S., Dijkstra, I. M. E., Waidhofer‐Söllner, P., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02664-y · Cited by 35 · see citing works
Self-citationPhosphoinositides regulate the TCR/CD3 complex membrane dynamics and activation
Benmansour, N. C., Ruminski, K., Sartre, A.-M., Phélipot, M.-C., Salles, A., Bergot, E., Wu, A., Chicanne, G., Fallet, M., Brustlein, S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23109-8 · Cited by 35 · see citing works
Self-citationCara, F. D. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008636 · Cited by 32 · see citing works
Beckers, L., Geric, I., Stroobants, S., Beel, S., Van Damme, P., D’Hooge, R., & Baes, M. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1442-3 · Cited by 30 · see citing works
Th 1 cytokine production by peripheral blood mononuclear cells in X-linked adrenoleukodystrophy
Biase, A. D., Merendino, N., Avellino, C., Cappa, M., & Salvati, S. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00469-x · Cited by 25 · see citing works
Inflammatory profile in X‐linked adrenoleukodystrophy patients: Understanding disease progression
Marchetti, D. P., Donida, B., Jacques, C. E. D., Deon, M., Hauschild, T. C., Koehler‐Santos, P., Coelho, D. D. M., Coitinho, A. S., Jardim, L. B., & Vargas, C. R. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26295 · Cited by 24 · see citing works
Bergner, C. G., Genc, N., Hametner, S., Franz, J., van der Meer, F., Mitkovski, M., Weber, M. S., Stoltenburg‐Didinger, G., Kühl, J., Köhler, W., et al. (2021) · Glia · doi:10.1002/glia.24042 · Cited by 23 · see citing works
Lannuzel, A., Aubourg, P. R., & Tardieu, M. (1998) · European Journal of Paediatric Neurology · doi:10.1016/1090-3798(98)01002-7 · Cited by 22 · see citing works
Li, S., Wernersbach, I., Harms, G. S., & Schäfer, M. K. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945485 · Cited by 20 · see citing works
Controlling T cells spreading, mechanics and activation by micropatterning
Sadoun, A., Biarnes‐Pelicot, M., Ghesquière‐Diérickx, L., Wu, A., Théodoly, O., Limozin, L., Hamon, Y., & Puech, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-86133-1 · Cited by 20 · see citing works
Self-citationDoroshenko, E. R., Drohomyrecky, P. C., Gower, A., Whetstone, H., Cahill, L., Ganguly, M., Spring, S., Yi, T., Sled, J., & Dunn, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.570425 · Cited by 18 · see citing works
The Role of Microglia in Inherited White-Matter Disorders and Connections to Frontotemporal Dementia
Sirkis, D. W., Bonham, L. W., & Yokoyama, J. S. (2021) · The Application of Clinical Genetics · doi:10.2147/tacg.s245029 · Cited by 18 · see citing works
Beckers, L., Stroobants, S., D’Hooge, R., & Baes, M. I. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00136 · Cited by 17 · see citing works
Peroxisomal defects in microglial cells induce a disease-associated microglial signature
Raas, Q., Tawbeh, A., Tahri-Joutey, M., Gondcaille, C., Keime, C., Kaiser, R., Trompier, D., Nasser, B., Leoni, V., Bellanger, E., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1170313 · Cited by 16 · see citing works
Self-citationCharacterization of the Leucocyte Immunoglobulin-like Receptor B4 (Lilrb4) Expression in Microglia
Kretzschmar, F., Piecha, R., Jahn, J., Potru, P. S., & Spittau, B. (2021) · Biology · doi:10.3390/biology10121300 · Cited by 13 · see citing works
T-cell receptor Vβ gene usage in CSF lymphocytes in X-linked adrenoleukodystrophy
Picard, F., Guidoux, S., Martin, T., Aubourg, P. R., & Pasquali, J. (2004) · Journal of Molecular Recognition · doi:10.1002/jmr.727 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Tawbeh, A., Gondcaille, C., Saih, F.-E., Raas, Q., Loichot, D., Hamon, Y., Keime, C., Benani, A., Di Cara, F., Cherkaoui-Malki, M., et al. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1542938 · Cited by 21 · see citing works
Self-citationRevisiting the Pathogenesis of X-Linked Adrenoleukodystrophy
Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11 · see citing works
- Authors
- Tawbeh, A., Raas, Q., Tahri-Joutey, M., Keime, C., Kaiser, R., Trompier, D., Nasser, B., Bellanger, E., Dessard, M., Hamon, Y., Benani, A., Di Cara, F., Cunha Alves, T., Berger, J., Weinhofer, I., Mandard, S., Cherkaoui-Malki, M., Andreoletti, P., Gondcaille, C., & Savary, S.
- Affiliations
- Université de Bourgogne (FR)
- Centre National de la Recherche Scientifique (FR)
- Université Hassan 1er (MA)
- Medical University of Vienna (AT)
- Inserm (FR)
- Corresponding author
- Savary, Stéphane
- ORCID
- Venue
- Frontiers in Molecular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2023-12-18
- Volume
- 16
- Pages
- 1299314-1299314
- ISSN
- 1662-5099 (ISSN-L)
- PMC
- PMC10757945
- OpenAlex
- W4389918699
- Cited by
- 18
- References
- 106
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 2
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Molecular Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- Agence Nationale de la Recherche (ANR-19-CE07-0044, ANR-10-INBS-0009, ANR-11-LABX-0021, ANR-17-CE15-0032)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Keywords
- microglia, peroxisomal beta-oxidation, X-linked adrenoleukodystrophy, very long chain fatty acids, BV-2 cells, ABCD1, ABCD2, ACOX1, lipopolysaccharide stimulation, inflammatory cytokines, phagocytosis, antigen presentation, inflammasome, TNF-α, lipid metabolism, neuroinflammation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
