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Cited by 19Physical Activity and HealthObesity, Physical Activity, DietContext-Aware Activity Recognition Systems

Associations of objectively measured moderate-to-vigorous-intensity physical activity and sedentary time with all-cause mortality in a population of adults at high risk of type 2 diabetes mellitus

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Bakrania, Kishan, Edwardson, Charlotte L., Khunti, Kamlesh, Henson, Joseph, Stamatakis, Emmanuel, Hamer, Mark, Davies, Melanie J., Yates, Thomas·2017·Preventive Medicine Reports
DOI 10.1016/j.pmedr.2017.01.013PMC PMC5279862
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Abstract

The relationships of physical activity and sedentary time with all-cause mortality in those at high risk of type 2 diabetes mellitus (T2DM) are unexplored. To address this gap in knowledge, we examined the associations of objectively measured moderate-to-vigorous-intensity physical activity (MVPA) and sedentary time with all-cause mortality in a population of adults at high risk of T2DM. In 2010-2011, 712 adults (Leicestershire, U.K.), identified as being at high risk of T2DM, consented to be followed up for mortality. MVPA and sedentary time were assessed by accelerometer; those with valid data (≥ 10 hours of wear-time/day with ≥ 4 days of data) were included. Cox proportional hazards regression models, adjusted for potential confounders, were used to investigate the independent associations of MVPA and sedentary time with all-cause mortality. 683 participants (250 females (36.6%)) were included and during a mean follow-up period of 5.7 years, 26 deaths were registered. Every 10% increase in MVPA time/day was associated with a 5% lower risk of all-cause mortality [Hazard Ratio (HR): 0.95 (95% Confidence Interval (95% CI): 0.91, 0.98); p = 0.004]; indicating that for the average adult in this cohort undertaking approximately 27.5 minutes of MVPA/day, this benefit would be associated with only 2.75 additional minutes of MVPA/day. Conversely, sedentary time showed no association with all-cause mortality [HR (every 10-minute increase in sedentary time/day): 0.99 (95% CI: 0.95, 1.03); p = 0.589]. These data support the importance of MVPA in adults at high risk of T2DM. The association between sedentary time and mortality in this population needs further investigation.

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  • Two studies from NHANES, a study from the Look AHEAD Trial, and a study from the Walking Away from Type 2 Diabetes trial all demonstrated significant risk reductions related to all-cause mortality with higher volumes of physical activity.

    “Two studies derived from the NHANES, a study from the Look AHEAD Trial and a study from the Walking Away from Type 2 Diabetes trial all demonstrated significant risk reductions in related to all-cause mortality with higher volumes of PA17–20.”

    From Accelerometer-derived physical activity and mortality in individuals with type 2 diabetes (2024) · cites this paper as [20]

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Authors
Bakrania, K., Edwardson, C. L., Khunti, K., Henson, J., Stamatakis, E., Hamer, M., Davies, M. J., & Yates, T.
Affiliations
  • University of Leicester (GB)
  • The University of Sydney (AU)
  • Loughborough University (GB)
Corresponding author
Bakrania, Kishan
ORCID
Venue
Preventive Medicine Reports
Publisher
Elsevier BV
Published
2017-03
Volume
5
Pages
285-288
ISSN
2211-3355 (ISSN-L)
DOI
10.1016/j.pmedr.2017.01.013
PMC
PMC5279862
OpenAlex
W2582892332
Cited by
19
References
22
Citations by year
2026: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1
FWCI
1.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Preventive Medicine Reports (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Loughborough University Institutional Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
  • Figshare (submittedVersion, cc-by-nc-nd)
  • Loughborough University Research Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
  • Leicester Research Archive (University of Leicester) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institute for Health Research (NIHR) Diet, Lifestyle & Physical Activity Biomedical Research Unit (BRU)
  • National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care – East Midlands (NIHR CLAHRC – EM)
  • Leicester Clinical Trials Unit
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Context-Aware Activity Recognition Systems
Keywords
moderate-to-vigorous physical activity, sedentary time, all-cause mortality, type 2 diabetes, high-risk adults, accelerometer-measured activity, diabetes prevention

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