The epigenetics of aging and neurodegeneration

Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.

Podlisny, M. B., Tolan, D. R., & Selkoe, D. J. (1991) · PubMed Central · Cited by 217

Sustained effects of nonallele‐specific Huntingtin silencing

Drouet, V., Perrin, V., Hässig, R., Dufour, N., Aurégan, G., Alves, S., Bonvento, G., Brouillet, E., Luthi‐Carter, R., Hantraye, P., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21569 · Cited by 217

Protein Phosphatase 1 Regulates the Histone Code for Long-Term Memory

Koshibu, K., Gräff, J., Beullens, M., Heitz, F. D., Berchtold, D., Russig, H., Farinelli, M., Bollen, M., & Mansuy, I. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3610-09.2009 · Cited by 216

RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA

Morse, D. P., Aruscavage, P. J., & Bass, B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112704299 · Cited by 215

Mechanical Stretch Up-regulates MicroRNA-26a and Induces Human Airway Smooth Muscle Hypertrophy by Suppressing Glycogen Synthase Kinase-3β

Mohamed, J. S., Lopez, M. A., & Boriek, A. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.101147 · Cited by 214

Environmental Neurotoxic Pesticide Increases Histone Acetylation to Promote Apoptosis in Dopaminergic Neuronal Cells: Relevance to Epigenetic Mechanisms of Neurodegeneration

Song, C., Kanthasamy, A., Anantharam, V., Sun, F., & Kanthasamy, A. (2010) · Molecular Pharmacology · doi:10.1124/mol.109.062174 · Cited by 214

Benefit of valproic acid in suppressing disease progression of ALS model mice

Sugai, F., Yamamoto, Y., Miyaguchi, K., Zhou, Z., Sumi, H., Hamasaki, T., Goto, M., & Sakoda, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03765.x · Cited by 214

Tissue‐specific dysregulation of DNA methylation in aging

Thompson, R. F., Atzmon, G., Gheorghe, C. P., Liang, H. Q., Lowes, C., Greally, J. M., & Barzilai, N. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00577.x · Cited by 213

Hypomethylation of the amyloid precursor protein gene in the brain of an alzheimer’s disease patient

West, R. L., Lee, J. M., & Maroun, L. E. (1995) · Journal of Molecular Neuroscience · doi:10.1007/bf02736773 · Cited by 213

Non‐coding RNAs: biological functions and applications

Santosh, B., Varshney, A., & Yadava, P. K. (2014) · Cell Biochemistry and Function · doi:10.1002/cbf.3079 · Cited by 212

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

Lahiri, D. K., Maloney, B., & Zawia, N. H. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.82 · Cited by 212

MicroRNA-101 downregulates Alzheimer’s amyloid-β precursor protein levels in human cell cultures and is differentially expressed

Long, J. M., & Lahiri, D. K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.053 · Cited by 211

Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease

Blalock, E. M., Buechel, H. M., Popovic, J., Geddes, J. W., & Landfield, P. W. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.06.007 · Cited by 211

DNA methylation in repetitive elements and Alzheimer disease

Bollati, V., Galimberti, D., Pergoli, L., Valle, E. D., Barretta, F., Cortini, F., Scarpini, E. A., Bertazzi, P. A., & Baccarelli, A. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.01.017 · Cited by 211

Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models

Sadri‐Vakili, G., Bouzou, B., Benn, C., Kim, M.-O., Chawla, P., Overland, R. P., Glajch, K. E., Xia, E., Qiu, Z., Hersch, S. M., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm078 · Cited by 210

Structure Prediction and Phylogenetic Analysis of a Functionally Diverse Family of Proteins Homologous to the MT-A70 Subunit of the Human mRNA:m6A Methyltransferase

Bujnicki, J. M., Feder, M., Radlińska, M., & Blumenthal, R. (2002) · Journal of Molecular Evolution · doi:10.1007/s00239-002-2339-8 · Cited by 210

Effect of aging on 5-hydroxymethylcytosine in brain mitochondria

Dzitoyeva, S., Chen, H., & Manev, H. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.02.006 · Cited by 209

MicroRNAs can regulate human APP levels

Patel, N., Hoang, D. M., Miller, N., Ansaloni, S., Huang, Q., Rogers, J. T., Lee, J. C., & Saunders, A. J. (2008) · Molecular Neurodegeneration · doi:10.1186/1750-1326-3-10 · Cited by 209

A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genesPreprint

Wood, M. A., Attner, M. A., Oliveira, A. M. M., Brindle, P. K., & Abel, T. G. (2006) · Learning & Memory · doi:10.1101/lm.213906 · Cited by 207

The microRNA cluster miR-106b 25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation

Brett, J. O., Renault, V. M., Rafalski, V. A., Webb, A. E., & Brunet, A. (2011) · Aging · doi:10.18632/aging.100285 · Cited by 207

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling

Olivieri, F., Lazzarini, R., Recchioni, R., Marcheselli, F., Rippo, M. R., Nuzzo, S., Albertini, M. C., Graciotti, L., Babini, L., Mariotti, S., et al. (2012) · AGE · doi:10.1007/s11357-012-9440-8 · Cited by 206

MicroRNA-195 downregulates Alzheimer's disease amyloid-β production by targeting BACE1

Zhu, H.-C., Wang, L.-M., Wang, M., Song, B., Tan, S., Teng, J.-F., & Duan, D.-X. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.05.018 · Cited by 204

Mitochondrial DNA in mortal and immortal human cells. Genome number, integrity, and methylation.

Reis, R. J. S., & Goldstein, S. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44633-3 · Cited by 203

Functional Analyses of the Transcription Factor Sp4 Reveal Properties Distinct from Sp1 and Sp3

Hagen, G., Dennig, J., Preiß, A., Beato, M., & Suske, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.24989 · Cited by 203

Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9

Jackman, J. E., Montange, R. K., Malik, H. S., & Phizicky, E. M. (2003) · RNA · doi:10.1261/rna.5070303 · Cited by 203

Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafishPreprint

Rai, K., Chidester, S., Zavala, C. V., Manos, E. J., James, S. R., Karpf, A. R., Jones, D. A., & Cairns, B. R. (2007) · Genes & Development · doi:10.1101/gad.1472907 · Cited by 201

TAF12 Recruits Gadd45a and the Nucleotide Excision Repair Complex to the Promoter of rRNA Genes Leading to Active DNA Demethylation

Schmitz, K., Schmitt, N., Hoffmann‐Rohrer, U., Schäfer, A., Grummt, I., & Mayer, C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.015 · Cited by 199

Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson's disease

St. Laurent, R., O’Brien, L. M., & Ahmad, S. T. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.037 · Cited by 199

MicroRNA-153 Physiologically Inhibits Expression of Amyloid-β Precursor Protein in Cultured Human Fetal Brain Cells and Is Dysregulated in a Subset of Alzheimer Disease Patients

Long, J. M., Ray, B., & Lahiri, D. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.366336 · Cited by 198

Epigenetic changes in the progression of Alzheimer's disease

Bradley‐Whitman, M. A., & Lovell, M. A. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.08.005 · Cited by 198

Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD+‐Dependent Histone Deacetylases (Sirtuins)

Trapp, J., Meier, R., Hongwiset, D., Kassack, M. U., Sippl, W., & Jung, M. (2007) · ChemMedChem · doi:10.1002/cmdc.200700003 · Cited by 198

B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-β deposition in mice

Fuso, A., Nicolia, V., Cavallaro, R. A., Ricceri, L., D’Anselmi, F., Coluccia, P., Calamandrei, G., & Scarpa, S. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.12.018 · Cited by 197

Presenilin 1 gene silencing by S ‐adenosylmethionine: a treatment for Alzheimer disease?

Scarpa, S., Fuso, A., D’Anselmi, F., & Cavallaro, R. A. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00277-1 · Cited by 196

Formation and development of Lewy pathology: a critical update

Jellinger, K. A. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5243-y · Cited by 195

Chemotherapy for the Brain: The Antitumor Antibiotic Mithramycin Prolongs Survival in a Mouse Model of Huntington's Disease

Ferrante, R. J., Ryu, H., Kubilus, J. K., D’Mello, S. R., Sugars, K. L., Lee, J.-H., Lu, P., Smith, K., Browne, S. E., Beal, M. F., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2599-04.2004 · Cited by 195

Targeted proteomics for quantification of histone acetylation in A lzheimer's disease

Zhang, K., Schrag, M., Crofton, A. R., Trivedi, R. K., Vinters, H. V., & Kirsch, W. M. (2012) · PROTEOMICS · doi:10.1002/pmic.201200010 · Cited by 195

Murine microRNAs implicated in liver functions and aging process

Maes, O. C., An, J., Sarojini, H., & Wang, E. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.05.004 · Cited by 193

MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice

Liu, W., Chang, L., Zhu, J.-X., Shu, P., Yin, B., Gong, Y., Qiang, B., Yuan, J., & Peng, X. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.034 · Cited by 193

DNA Methylation of Alzheimer Disease and Tauopathy-Related Genes in Postmortem Brain

Barrachina, M., & Ferrer, I. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181af2e46 · Cited by 192

miR-146a is modulated in human endothelial cell with aging

Vasa‐Nicotera, M., Chen, H., Tucci, P., Yang, A. L., Saintigny, G., Menghini, R., Mahé, C., Agostini, M., Knight, R. A., Melino, G., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.03.034 · Cited by 192

Amino-terminal sequence identity of ubiquitin and the nonhistone component of nuclear protein A24

Hunt, L. T., & Dayhoff, M. O. (1977) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(77)90352-7 · Cited by 190

MicroRNAs in neurodegenerative diseases and their therapeutic potential

Junn, E., & Mouradian, M. M. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.10.002 · Cited by 186

Extensive changes in DNA methylation are associated with expression of mutant huntingtin

Ng, C., Yildirim, F., Yap, Y. S., Dalin, S., Matthews, B. J., Vélez, P., Labadorf, A. T., Housman, D. E., & Fraenkel, E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221292110 · Cited by 185

The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO

Boulias, K., & Horvitz, H. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.014 · Cited by 184

miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease

Wang, W., Wilfred, B. R., Madathil, S. K., Tang, G., Hu, Y., Dimayuga, J., Stromberg, A. J., Huang, Q., Saatman, K. E., & Nelson, P. T. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091202 · Cited by 183

Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease

Zhou, W., Bercury, K. K., Cummiskey, J., Luong, N., Lebin, J. A., & Freed, C. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.211029 · Cited by 183

MicroRNAs with a nucleolar location

Politz, J. C. R., Hogan, E. M., & Pederson, T. (2009) · RNA · doi:10.1261/rna.1470409 · Cited by 183

Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia

Akbarian, S., Smith, M. A., & Jones, E. G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00922-d · Cited by 183

In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs: APP splicing is regulated by microRNAs

Smith, P., Al Hashimi, A., Girard, J., Delay, C., & Hébert, S. S. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07097.x · Cited by 182

Genetics and Epigenetics of Parkinson's Disease

Coppedè, F. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/489830 · Cited by 182

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease

Siddiqui, A., Chinta, S. J., Mallajosyula, J. K., Rajagopolan, S., Hanson, I. M., Rane, A., Melov, S., & Andersen, J. K. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.024 · Cited by 182

Tau – an inhibitor of deacetylase HDAC6 function

Perez, M., Santa‐Maria, I., De Barreda, E. G., Zhu, X., Cuadros, R., Cabrero, J. R., Sanchez‐Madrid, F., Dawson, H. N., Vitek, M. P., Perry, G., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06102.x · Cited by 182

DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation

Hutnick, L. K., Golshani, P., Namihira, M., Xue, Z., Matynia, A., Yang, X. W., Silva, A. J., Schweizer, F. E., & Fan, G. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp222 · Cited by 181

Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma

Orr, B. A., Haffner, M. C., Nelson, W. G., Yegnasubramanian, S., & Eberhart, C. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041036 · Cited by 180

Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes

de Groote, M. L., Verschure, P. J., & Rots, M. G. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks863 · Cited by 180

Two related ARID family proteins are alternative subunits of human SWI/SNF complexes

Xiaomei, W. A. N. G., Nagl, N. G., Wilsker, D. F., Scoy, M. V., Pacchione, S. J., Yaciuk, P., Dallas, P. B., & Morán, E. (2004) · Biochemical Journal · doi:10.1042/bj20040524 · Cited by 178

Human DNMT2 methylates tRNAAsp molecules using a DNA methyltransferase-like catalytic mechanism

Jurkowski, T. P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G., & Jeltsch, A. (2008) · RNA · doi:10.1261/rna.970408 · Cited by 178

Variant TREM2 as Risk Factor for Alzheimer's Disease

Neumann, H., & Daly, M. J. (2013) · New England Journal of Medicine · doi:10.1056/nejme1213157 · Cited by 177 · cited 2×

A Novel Activator of CBP/p300 Acetyltransferases Promotes Neurogenesis and Extends Memory Duration in Adult Mice

Chatterjee, S., Mizar, P., Cassel, R., Neidl, R., Selvi, B. R., Mohankrishna, D. V., Vedamurthy, B. M., Schneider‐Anthony, A., Bousiges, O., Mathis, C., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5772-12.2013 · Cited by 177

Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficitsPreprint

Oliveira, A. M. M., Wood, M. A., McDonough, C. B., & Abel, T. G. (2007) · Learning & Memory · doi:10.1101/lm.656907 · Cited by 177

Definition of pRB- and p53-Dependent and -Independent Steps in HIRA/ASF1a-Mediated Formation of Senescence-Associated Heterochromatin Foci

Ye, X., Zerlanko, B. J., Zhang, R., Somaiah, N., Lipinski, M., Salomoni, P., & Adams, P. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01592-06 · Cited by 177

Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

Chen, P. Y., Weinmann, L., Gaidatzis, D., Pei, Y., Zavolan, M., Tuschl, T., & Meister, G. (2008) · RNA · doi:10.1261/rna.789808 · Cited by 176

Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?

Ogawa, O., Zhu, X., Lee, H., Raina, A. K., Obrenovich, M. E., Bowser, R. P., Ghanbari, H. A., Castellani, R. J., Perry, G. L., & Smith, M. A. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0684-3 · Cited by 175

The Cochaperone BAG2 Sweeps Paired Helical Filament- Insoluble Tau from the Microtubule

Carrettiero, D. C., Hernández, I., Neveu, P. A., Papagiannakopoulos, T. Y., & Kosik, K. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4660-08.2009 · Cited by 175

Regionally specific and genome-wide analyses conclusively demonstrate the absence of CpG methylation in human mitochondrial DNA

Hong, E. E., Okitsu, C. Y., Smith, A. D., & Hsieh, C.-L. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00220-13 · Cited by 175

Genome-wide association between DNA methylation and alternative splicing in an invertebrate

Flores, K., Wolschin, F., Corneveaux, J. J., Allen, A. N., Huentelman, M. J., & Amdam, G. V. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-480 · Cited by 174

The Role of Clusterin in Alzheimer’s Disease: Pathways, Pathogenesis, and Therapy

Yu, J.-T., & Tan, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8237-1 · Cited by 174

High-Resolution Enzymatic Mapping of Genomic 5-Hydroxymethylcytosine in Mouse Embryonic Stem Cells

Sun, Z., Terragni, J., Borgaro, J. G., Liu, Y., Yu, L., Guan, S., Wang, H., Sun, D., Cheng, X., Zhu, Z., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.001 · Cited by 173

Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease

Jia, H., Pallos, J., Jacques, V., Lau, A., Tang, B., Cooper, A. C., Syed, A., Purcell, J. M., Chen, Y., Sharma, S., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.01.016 · Cited by 173

P1–160: Olfactory identification as a potential marker of presymptomatic Alzheimer's disease

Lafaille‐Magnan, M., Breitner, J. C. S., Etienne, P. E., Poirier, J., Fontaine, D. J., Rosa‐Neto, P., & Rajah, N. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.05.383 · Cited by 172

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

Abeti, R., Abramov, A. Y., & Duchen, M. R. (2011) · Brain · doi:10.1093/brain/awr104 · Cited by 172

5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence

Zhu, B. M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.21.4157 · Cited by 172

Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation

Iskandar, B. J., Rizk, E., Meier, B. M., Hariharan, N., Bottiglieri, T., Finnell, R. H., Jarrard, D. F., Banerjee, R. V., Skene, J. H. P., Nelson, A. B., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40000 · Cited by 171

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

Myung, N.-H., Zhu, X., Kruman, I. I., Castellani, R. J., Petersen, R. B., Siedlak, S. L., Perry, G., Smith, M. A., & Lee, H.-G. (2008) · AGE · doi:10.1007/s11357-008-9050-7 · Cited by 170

Histone deacetylases 1 and 2 are expressed at distinct stages of neuro‐glial development

MacDonald, J. L., & Roskams, A. J. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21626 · Cited by 169

Altered Memory Capacities and Response to Stress in p300/CBP-Associated Factor (PCAF) Histone Acetylase Knockout Mice

Maurice, T., Duclot, F., Meunier, J., Naert, G., Givalois, L., Meffre, J., Célérier, A., Jacquet, C., Copois, V., Mechti, N., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301551 · Cited by 169

Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia

Peng, G.-S., Li, G., Tzeng, N., Chen, P.-S., Chuang, D., Hsu, Y., Yang, S., & Hong, J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.10.021 · Cited by 169

ADAR Gene Family and A-to-I RNA Editing: Diverse Roles in Posttranscriptional Gene Regulation

Valente, L., & Nishikura, K. (2005) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(04)79006-6 · Cited by 168

Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats

Egorin, M. J., Yuan, Z.-M., Sentz, D. L., Plaisance, K. I., & Eiseman, J. L. (1999) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800050922 · Cited by 166

RNA traffic control of chromatin complexes

Koziol, M. J., & Rinn, J. L. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.03.003 · Cited by 164

α-Synuclein Negatively Regulates Protein Kinase Cδ Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity

Jin, H., Kanthasamy, A., Ghosh, A., Yang, Y., Anantharam, V., & Kanthasamy, A. G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5634-10.2011 · Cited by 164

DNA methylation based biomarkers: Practical considerations and applications

Kit, A. H., Nielsen, H. M., & Tost, J. (2012) · Biochimie · doi:10.1016/j.biochi.2012.07.014 · Cited by 163

Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-β

Schönrock, N., Humphreys, D. T., Preiß, T., & Götz, J. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9587-2 · Cited by 163

SAHA Decreases HDAC 2 and 4 Levels In Vivo and Improves Molecular Phenotypes in the R6/2 Mouse Model of Huntington's Disease

Mielcarek, M., Benn, C., Franklin, S., Smith, D. L., Woodman, B., Marks, P. A., & Bates, G. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027746 · Cited by 163

Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment

Huynh, J. L., & Casaccia, P. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70309-5 · Cited by 162

Presenilins and Alzheimer’s disease: biological functions and pathogenic mechanisms

Czech, C., Tremp, G. L., & Pradier, L. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00033-7 · Cited by 160

AAV Vector–mediated RNAi of Mutant Huntingtin Expression Is Neuroprotective in a Novel Genetic Rat Model of Huntington's Disease

Franich, N. R., Fitzsimons, H. L., Fong, D. M., Klugmann, M., During, M. J., & Young, D. (2008) · Molecular Therapy · doi:10.1038/mt.2008.50 · Cited by 160

The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae

Anderson, J. T., Phan, L. D., & Hinnebusch, A. G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090102597 · Cited by 159

Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus

Zhang, C.-E., Tian, Q., Wei, W., Peng, J.-H., Liu, G., Zhou, X., Wang, Q., Wang, D. W., & Wang, J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.015 · Cited by 159

Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts

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Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse

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