CoChat
Sign Up
Cited by 136

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy

Smith, Pascal Y., Delay, Charlotte, Girard, Johanne, Papon, Marie-Amélie, Planel, Emmanuel, Sergeant, Nicolas, Buée, Luc, Hébert, Sébastien S.·2011·Human Molecular Genetics
DOI 10.1093/hmg/ddr330
Open this paper in CoChat — free account

Abstract

Tauopathies represent a large class of neurological and movement disorders characterized by abnormal intracellular deposits of the microtubule-associated protein tau. It is now well established that mis-splicing of tau exon 10, causing an imbalance between three-repeat (3R) and four-repeat (4R) tau isoforms, can cause disease; however, the underlying mechanisms affecting tau splicing in neurons remain poorly understood. The small noncoding microRNAs (miRNAs), known for their critical role in posttranscriptional gene expression regulation, are increasingly acknowledged as important regulators of alternative splicing. Here, we identified a number of brain miRNAs, including miR-124, miR-9, miR-132 and miR-137, which regulate 4R:3R-tau ratios in neuronal cells. Analysis of miRNA expression profiles from sporadic progressive supranuclear palsy (PSP) patients, a major 4R-tau tauopathy, showed that miR-132 is specifically down-regulated in disease. We demonstrate that miR-132 directly targets the neuronal splicing factor polypyrimidine tract-binding protein 2 (PTBP2), which protein levels were increased in PSP patients. miR-132 overexpression or PTBP2 knockdown similarly affected endogenous 4R:3R-tau ratios in neuronal cells. Finally, we provide evidence that miR-132 is inversely correlated with PTBP2 during post-natal brain development at the time when 4R-tau becomes expressed. Taken together, these results suggest that changes in the miR-132/PTBP2 pathway could contribute to the a…

Overview

Integrity signals

Registry

Crossref · 10.1093/hmg/ddr330

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Among the AD-specific targets were PTBP2, LYN, NFE2L2, ZEB2, SPRED1, and RASA1.

    “Amongst these AD-specific targets were genes like PTBP2, a previously identified miR-132 target implicated in Tau mRNA splicing [85], LYN, a kinase shown to play a role in amyloid-β-triggered neurotoxicity and TAU hyperphosphorylation [86], and NFE2L2, ZEB2, SPRED1 and RASA1, all previously shown to be regulated by miR-132 [87–89] (Fig. 5F).”

    From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [85]

  • PTBP2 is a previously identified miR-132 target implicated in Tau mRNA splicing.

    “Amongst these AD-specific targets were genes like PTBP2, a previously identified miR-132 target implicated in Tau mRNA splicing [85], LYN, a kinase shown to play a role in amyloid-β-triggered neurotoxicity and TAU hyperphosphorylation [86], and NFE2L2, ZEB2, SPRED1 and RASA1, all previously shown to be regulated by miR-132 [87–89] (Fig. 5F).”

    From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [85]

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 35

  1. Buee, 2000, Tau protein isoforms, phosphorylation and role in neurodegenerative disorders, Brain Res. Brain Res. Rev., 33, 95, 10.1016/S0165-0173(00)00019-9 · DOI
  2. Takuma, 2003, Isoforms changes of tau protein during development in various species, Brain Res. Dev. Brain Res., 142, 121, 10.1016/S0165-3806(03)00056-7 · DOI
  3. Janke, 1999, Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders, Brain Res. Mol. Brain Res., 68, 119, 10.1016/S0169-328X(99)00079-0 · DOI
  4. Gallo, 2007, RNA and protein-dependent mechanisms in tauopathies: consequences for therapeutic strategies, Cell Mol. Life Sci., 64, 1701, 10.1007/s00018-007-6513-4 · DOI
  5. Liu, 2008, Tau exon 10 alternative splicing and tauopathies, Mol. Neurodegener., 3, 8, 10.1186/1750-1326-3-8 · DOI · Paper page
  6. Sergeant, 1999, Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms, J. Neurochem., 72, 1243, 10.1046/j.1471-4159.1999.0721243.x · DOI
  7. Buee, 1999, Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease, Brain Pathol, 9, 681, 10.1111/j.1750-3639.1999.tb00550.x · DOI
  8. Fineberg, 2009, MicroRNAs potentiate neural development, Neuron, 64, 303, 10.1016/j.neuron.2009.10.020 · DOI
  9. Ambros, 2004, The functions of animal microRNAs, Nature, 431, 350, 10.1038/nature02871 · DOI · Paper page
  10. Djuranovic, 2011, parsimonious model for gene regulation by miRNAs, Science, 331, 550, 10.1126/science.1191138 · DOI
  11. Hobert, 2008, Gene regulation by transcription factors and microRNAs, Science, 319, 1785, 10.1126/science.1151651 · DOI · Paper page
  12. Makeyev, 2007, The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing, Mol. Cell, 27, 435, 10.1016/j.molcel.2007.07.015 · DOI · Paper page
  13. Spellman, 2007, Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1, Mol. Cell, 27, 420, 10.1016/j.molcel.2007.06.016 · DOI · Paper page
  14. Robinson, 2008, Expression of human nPTB is limited by extreme suboptimal codon content, PLoS ONE, 3, e1801, 10.1371/journal.pone.0001801 · DOI
  15. Hebert, 2010, Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration, Hum. Mol. Genet., 19, 3959, 10.1093/hmg/ddq311 · DOI
  16. Lewis, 2005, Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets, Cell, 120, 15, 10.1016/j.cell.2004.12.035 · DOI · Paper page
  17. Bilen, 2006, MicroRNA pathways modulate polyglutamine-induced neurodegeneration, Mol. Cell, 24, 157, 10.1016/j.molcel.2006.07.030 · DOI
  18. Wang, 2004, Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors, J. Neurochem., 88, 1078, 10.1046/j.1471-4159.2003.02232.x · DOI
  19. Xu, 2011, Polypyrimidine tract-binding protein 2 binds to selective, intronic messenger RNA and microRNA targets in the mouse testis, Biol. Reprod., 84, 435, 10.1095/biolreprod.110.087114 · DOI
  20. Coutinho-Mansfield, 2007, PTB/nPTB switch: a post-transcriptional mechanism for programming neuronal differentiation, Genes Dev., 21, 1573, 10.1101/gad.1575607 · DOI
  21. Sephton, 2011, Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes, J. Biol. Chem., 286, 1204, 10.1074/jbc.M110.190884 · DOI
  22. Auweter, 2008, Structure-function relationships of the polypyrimidine tract binding protein, Cell Mol. Life Sci., 65, 516, 10.1007/s00018-007-7378-2 · DOI
  23. Veo, 2009, Translation initiation of the human tau mRNA through an internal ribosomal entry site, J. Alzheimers Dis., 16, 271, 10.3233/JAD-2009-0978 · DOI
  24. Smith, 2011, In vivo regulation of Amyloid precursor protein neuronal splicing by microRNAs, J. Neurochem., 116, 240, 10.1111/j.1471-4159.2010.07097.x · DOI · Paper page
  25. Tang, 2011, Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein, J. Biol. Chem., 286, 10007, 10.1074/jbc.M110.208116 · DOI
  26. Nowak, 2011, The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA, Nat. Immunol., 12, 160, 10.1038/ni.1977 · DOI
  27. Li, 2003, Modulation of the membrane-binding domain of tau protein: splicing regulation of exon 2, Brain Res. Mol. Brain Res., 116, 94, 10.1016/S0169-328X(03)00259-6 · DOI
  28. Sonntag, 2010, MicroRNAs and deregulated gene expression networks in neurodegeneration, Brain Res., 1338, 48, 10.1016/j.brainres.2010.03.106 · DOI
  29. Eacker, 2009, Understanding microRNAs in neurodegeneration, Nat. Rev. Neurosci., 10, 837, 10.1038/nrn2726 · DOI · Paper page
  30. Hebert, 2008, Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression, Proc. Natl Acad. Sci. USA, 105, 6415, 10.1073/pnas.0710263105 · DOI · Paper page
  31. Wang, 2008, The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1, J. Neurosci., 28, 1213, 10.1523/JNEUROSCI.5065-07.2008 · DOI
  32. Magill, 2010, microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus, Proc. Natl Acad. Sci. USA, 107, 20382, 10.1073/pnas.1015691107 · DOI · Paper page
  33. Impey, 2010, An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling, Mol. Cell Neurosci., 43, 146, 10.1016/j.mcn.2009.10.005 · DOI · Paper page
  34. Hansen, 2011, Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory, PLoS ONE, 5, e15497, 10.1371/journal.pone.0015497 · DOI
  35. Hebert, 2006, Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes, EMBO Rep., 7, 739, 10.1038/sj.embor.7400704 · DOI

Cited by

Sorted by citations

Metadata

Authors
Smith, P. Y., Delay, C., Girard, J., Papon, M.-A., Planel, E., Sergeant, N., Buée, L., & Hébert, S. S.
Venue
Human Molecular Genetics
Publisher
Oxford University Press (OUP)
Published
2011-08-01
Volume
20
Issue
20
Pages
4016-4024
ISSN
  • 1460-2083
  • 0964-6906
DOI
10.1093/hmg/ddr330
Cited by
136
References
6
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review