Cited by 390Epigenetics and DNA MethylationGenomics and Chromatin DynamicsDementia and Cognitive Impairment Research

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The epigenetics of aging and neurodegeneration

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Lardenoije, Roy, Iatrou, Artemis, Kenis, Gunter, Kompotis, Konstantinos, Steinbusch, Harry W.M., Mastroeni, Diego, Coleman, Paul, Lemere, Cynthia A., Hof, Patrick R., van den Hove, Daniel L.A., Rutten, Bart P.F.·2015·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2015.05.002PMC PMC6477921

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Abstract

Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of increasing relevance to neuroscience, with epigenetic mechanisms being implicated in brain development and neuronal differentiation, as well as in more dynamic processes related to cognition. Epigenetic regulation covers multiple levels of gene expression; from direct modifications of the DNA and histone tails, regulating the level of transcription, to interactions with messenger RNAs, regulating the level of translation. Importantly, epigenetic dysregulation currently garners much attention as a pivotal player in aging and age-related neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it may mediate interactions between genetic and environmental risk factors, or directly interact with disease-specific pathological factors. We review current knowledge about the major epigenetic mechanisms, including DNA methylation and DNA demethylation, chromatin remodeling and non-coding RNAs, as well as the involvement of these mechanisms in normal aging and in the pathophysiology of the most common neurodegenerative diseases. Additionally, we examine the current state of epigenetics-based therapeutic strategies for these diseases, which either aim to restore the epigenetic homeostasis or skew it to a favorable direction to counter disease pathology. Finally, methodological challenges of epigenetic investigations and future perspectives are discussed.

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Authors: Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., & Rutten, B. P. F.
Affiliations: Maastricht University (NL)
University of Lausanne (CH)
Banner Sun Health Research Institute (US)
Brigham and Women's Hospital (US)
Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Rutten, Bart P.F.
ORCID: Lardenoije, Roy
Iatrou, Artemis
Kompotis, Konstantinos
Steinbusch, Harry W.M.
Mastroeni, Diego
Coleman, Paul
Lemere, Cynthia A.
Hof, Patrick R.
Rutten, Bart P.F.
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2015-08
Volume: 131
Pages: 21-64
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2015.05.002
PMC: PMC6477921
OpenAlex: W648684004
Cited by: 381
References: 770
Citations by year: 2026: 12 · 2025: 29 · 2024: 28 · 2023: 28 · 2022: 32 · 2021: 47 · 2020: 30 · 2019: 42 · 2018: 39 · 2017: 43 · 2016: 38 · 2015: 11
FWCI: 4.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion)
Funders: Internationale Stichting Alzheimer Onderzoek (07551, 11532, 09552, 13515)
Netherlands Organization for Scientific Research (916.11.086)
National Institutes of Health (P50 AG005138)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: epigenetics, aging, neurodegeneration, DNA methylation, DNA demethylation, chromatin remodeling, non-coding RNA, Alzheimer's disease, Parkinson's disease, Huntington's disease, epigenetic therapy, gene expression regulation, histone modifications
MeSH terms: Aging, Animals, Humans, DNA Methylation, Neurodegenerative Diseases, Genetic Predisposition to Disease, RNA, Untranslated, Epigenesis, Genetic

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