Cited by 390Epigenetics and DNA MethylationGenomics and Chromatin DynamicsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 765 of the 770 references it cites were found in a registry or an index.

The epigenetics of aging and neurodegeneration

Open access

Lardenoije, Roy, Iatrou, Artemis, Kenis, Gunter, Kompotis, Konstantinos, Steinbusch, Harry W.M., Mastroeni, Diego, Coleman, Paul, Lemere, Cynthia A., Hof, Patrick R., van den Hove, Daniel L.A., Rutten, Bart P.F.·2015·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2015.05.002PMC PMC6477921

Open this paper in CoChat — free account

Abstract

Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of increasing relevance to neuroscience, with epigenetic mechanisms being implicated in brain development and neuronal differentiation, as well as in more dynamic processes related to cognition. Epigenetic regulation covers multiple levels of gene expression; from direct modifications of the DNA and histone tails, regulating the level of transcription, to interactions with messenger RNAs, regulating the level of translation. Importantly, epigenetic dysregulation currently garners much attention as a pivotal player in aging and age-related neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it may mediate interactions between genetic and environmental risk factors, or directly interact with disease-specific pathological factors. We review current knowledge about the major epigenetic mechanisms, including DNA methylation and DNA demethylation, chromatin remodeling and non-coding RNAs, as well as the involvement of these mechanisms in normal aging and in the pathophysiology of the most common neurodegenerative diseases. Additionally, we examine the current state of epigenetics-based therapeutic strategies for these diseases, which either aim to restore the epigenetic homeostasis or skew it to a favorable direction to counter disease pathology. Finally, methodological challenges of epigenetic investigations and future perspectives are discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.pneurobio.2015.05.002

Cites

765 of 765 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

4 retracted

Items 601–765 of 765

From Waddington’s epigenetic landscape to small noncoding RNA: some important milestones in the history of epigenetics research
Choudhuri, S. (2011) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2011.559695 · Cited by 91
Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8
Wang, C. M., Tsai, S. N., Yew, T. W. D., Kwan, Y. W., & Ngai, S. M. (2009) · Biogerontology · doi:10.1007/s10522-009-9231-5 · Cited by 91
Age-Related Increase in Levels of 5-Hydroxymethylcytosine in Mouse Hippocampus is Prevented by Caloric Restriction
Chouliaras, L., L.A. van den Hove, D., Kenis, G., Keitel, S., R. Hof, P., van Os, J., W.M. Steinbusch, H., Schmitz, C., & P.F. Rutten, B. (2012) · Current Alzheimer Research · doi:10.2174/156720512800618035 · Cited by 91
Self-citation
Age-related difference of site-specific histone modifications in rat liver
Kawakami, K., Nakamura, A., Ishigami, A., Goto, S., & Takahashi, R. (2008) · Biogerontology · doi:10.1007/s10522-008-9176-0 · Cited by 91
Epigenetic Mechanisms of Neurodegeneration in Huntington's Disease
Lee, J.-H., Hwang, Y. J., Kim, K. Y., Kowall, N. W., & Ryu, H. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0206-5 · Cited by 90
HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila
Xiong, Y., Zhao, K., Wu, J., Xu, Z., Jin, S., & Zhang, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207586110 · Cited by 90
Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus
Chouliaras, L., van den Hove, D. L. A., Kenis, G., Dela Cruz, J., Lemmens, M. A. M., van Os, J., Steinbusch, H. W. M., Schmitz, C., & Rutten, B. P. F. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.11.016 · Cited by 89 · cited 15×
“Furthermore, there is another DNMT, DNMT3-like (DNMT3L), which exhibits no enzymatic activity, but detects unmethylated lysine 4 of histone H3 tails (H3K4) and recruits or activates DNMT3a (Ooi et al., 2007).”
BackgroundResultInfluentialSelf-citation
Sodium phenylbutyrate in Huntington's disease: A dose‐finding study
Hogarth, P., Lovrečić, L., & Krainc, D. (2007) · Movement Disorders · doi:10.1002/mds.21632 · Cited by 89
Current status and future prospects for epigenetic psychopharmacology
Boks, M. P., de Jong, N. M., Kas, M. J. H., Vinkers, C. H., Fernandes, C., Kahn, R. S., Mill, J., & Ophoff, R. A. (2012) · Epigenetics · doi:10.4161/epi.7.1.18688 · Cited by 89
Extensive relationship between antisense transcription and alternative splicing in the human genomePreprint
Morrissy, A. S., Griffith, M., & Marra, M. A. (2011) · Genome Research · doi:10.1101/gr.113431.110 · Cited by 88
The nucleotide sequence of nuclear 4.8S RNA of mouse cells
Harada, F., Kato, N., & Nishimura, S. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(80)91620-4 · Cited by 88
Epigenome-Wide Association Study for Parkinson’s Disease
Moore, K., McKnight, A. J., Craig, D., & O’Neill, F. A. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8332-8 · Cited by 87
Polyglutamine diseases: a transcription disorder?
Okazawa, H. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3013-z · Cited by 87
Inhibition of the Neuronal Insulin Receptor An in Vivo Model for Sporadic Alzheimer Disease?
Hoyer, S., Lee, S. K., Löffler, T., & Schliebs, R. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06932.x · Cited by 87
Sodium Phenylacetate Inhibits Adoptive Transfer of Experimental Allergic Encephalomyelitis in SJL/J Mice at Multiple Steps
Dasgupta, S., Zhou, Y., Jana, M., Banik, N. L., & Pahan, K. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.7.3874 · Cited by 87
ΔNp63&alpha Overexpression Induces Downregulation of Sirt1 and an Accelerated Aging Phenotype in the Mouse
Sommer, M., Poliak, N., Upadhyay, S. K., Ratovitski, E. A., Nelkin, B. D., Donehower, L. A., & Sidransky, D. (2006) · Cell Cycle · doi:10.4161/cc.5.17.3194 · Cited by 86
Promoter Methylation Analysis of SIRT3, SMARCA5, HTERT and CDH1 Genes in Aging and Alzheimer's Disease
Silva, P. N., Gigek, C. O., Leal, M. F., Bertolucci, P. H. F., de Lábio, R. W., Payão, S. L. M., & Smith, M. D. A. C. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13207 · Cited by 86
Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells
Suuronen, T., Nuutinen, T., Ryhänen, T., Kaarniranta, K., & Salminen, A. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.135 · Cited by 85
Epigenetic regulation of BACE1 in Alzheimer’s disease patients and in transgenic mice
Marques, S., Lemos, R., Ferreiro, E. B., Martins, M., de Mendonça, A., Santana, I. J., Outeiro, T. F., & Pereira, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.029 · Cited by 84
APOBEC3 proteins: major players in intracellular defence against LINE-1-mediated retrotransposition
Schumann, G. G. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350637 · Cited by 83
Effect of valproic acid on mitochondrial epigenetics
Chen, H., Dzitoyeva, S., & Manev, H. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.019 · Cited by 83
Tip60 HAT Activity Mediates APP Induced Lethality and Apoptotic Cell Death in the CNS of a Drosophila Alzheimer's Disease Model
Pirooznia, S. K., Sarthi, J. B., Johnson, A. A., Toth, M. S., Chiu, K., Koduri, S., & Elefant, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041776 · Cited by 83
Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression
Rossi, L. E., Avila, D. E., Spallanzani, R. G., Ziblat, A., Fuertes, M. B., Lapyckyj, L., Croci, D. O., Rabinovich, G. A., Domaica, C. I., & Zwirner, N. W. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0711339 · Cited by 83
Epigenetic programming of neurodegenerative diseases by an adverse environment
Babenko, O., Kovalchuk, I., & Metz, G. A. S. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.038 · Cited by 80
Role of the N6-methyladenosine RNA mark in gene regulation and its implications on development and disease
Chandola, U., Das, R., & Panda, B. (2014) · Briefings in Functional Genomics · doi:10.1093/bfgp/elu039 · Cited by 80
Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytesPreprint
Parra, M., Mahmoudi, T., & Verdin, E. M. (2007) · Genes & Development · doi:10.1101/gad.1513107 · Cited by 80
S100 proteins in Corpora Amylacea from normal human brain11Published on the World Wide Web on 5 May 2000.
Hoyaux, D., Decaestecker, C., Heizmann, C. W., Vogl, T. J., Schäfer, B. W., Salmon, I. J., Robert Kiss, A., & Pochet, R. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02393-3 · Cited by 79
Epigenetic studies in Alzheimer's disease: Current findings, caveats, and considerations for future studies
Lunnon, K., & Mill, J. (2013) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32201 · Cited by 78
Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction
Chouliaras, L., van den Hove, D. L. A., Kenis, G., Keitel, S., Hof, P. R., van Os, J., Steinbusch, H. W. M., Schmitz, C., & Rutten, B. P. F. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.003 · Cited by 78
Self-citation
Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus
Brown, S. E., Weaver, I. C. G., Meaney, M. J., & Moshe Szyf, A. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.028 · Cited by 77
Histone acetylation during aging of human cells in culture
Ryan, J. M., & Cristofalo, V. J. (1972) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(72)90668-7 · Cited by 77
Increasing Tip60 HAT Levels Rescues Axonal Transport Defects and Associated Behavioral Phenotypes in aDrosophilaAlzheimer's Disease Model
Johnson, A. A., Sarthi, J. B., Pirooznia, S. K., Reube, W., & Elefant, F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3739-12.2013 · Cited by 76
Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications
Szyf, M. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.01.009 · Cited by 76
Epigenetics in the Human Brain
Houston, I. B., Peter, C. J., Mitchell, A., Straubhaar, J., Rogaev, E. I., & Akbarian, S. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.78 · Cited by 75
Histone H1 Poly[ADP]-Ribosylation Regulates the Chromatin Alterations Required for Learning Consolidation
Fontán‐Lozano, Á., Suárez‐Pereira, I., Horrillo, A., Martín, Y. D. P., Hmadcha, A., & Carrión, Á. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3010-10.2010 · Cited by 74
Folate, Homocysteine, Vitamin B12, and Polymorphisms of Genes Participating in One-Carbon Metabolism in Late-Onset Alzheimer's Disease Patients and Healthy Controls
Coppedè, F., Tannorella, P., Pezzini, I., Migheli, F., Ricci, G., Ienco, E. C., Piaceri, I., Polini, A., Nacmias, B., Monzani, F., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4368 · Cited by 74
MicroRNA and proteome expression profiling in early‐symptomatic α‐synuclein(A30P)‐transgenic mice
Gillardon, F., Mack, M., Rist, W., Schnack, C., Lenter, M., Hildebrandt, T., & Hengerer, B. (2008) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200780025 · Cited by 73
Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type.
Kumar, A., Seghal, N., Naidu, P. S., Padi, S. S. V., & Goyal, R. (2007) · PubMed · Cited by 73
Active DNA demethylation in post-mitotic neurons: A reason for optimism
Gavin, D. P., Chase, K. A., & Sharma, R. P. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.036 · Cited by 72
MicroRNAs and the Regulation of Tau Metabolism
Hébert, S. S., Sergeant, N., & Buée, L. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/406561 · Cited by 72
Developmental Regulation of MicroRNA Expression in Schwann Cells
Gokey, N. G., Srinivasan, R., Lopez‐Anido, C., Krueger, C., & Svaren, J. P. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06270-11 · Cited by 72
Reduced RAN Expression and Disrupted Transport between Cytoplasm and Nucleus; A Key Event in Alzheimer’s Disease Pathophysiology
Mastroeni, D., Chouliaras, L., Grover, A., Liang, W. S., Hauns, K., Rogers, J., & Coleman, P. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053349 · Cited by 72
Self-citation
Inducible PC12 cell model of Huntington’s disease shows toxicity and decreased histone acetylation
Igarashi, S., Morita, H., Bennett, K. M., Tanaka, Y., Engelender, S., Peters, M. F., Cooper, J. K., Wood, J. D., Sawa, A., & Ross, C. A. (2003) · Neuroreport · doi:10.1097/00001756-200303240-00007 · Cited by 72
Purkinje cell loss and astrocytosis in the cerebellum in familial and sporadic Alzheimer's disease
Fukutani, Y., Cairns, N. J., Rossor, M. N., & Lantos, P. L. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12875-5 · Cited by 71
Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma—Epigenetic downregulation of caspases
Müerköster, S. S., Werbing, V., Koch, D., Sipos, B., Ammerpohl, O., Kalthoff, H., Tsao, M., Fölsch, U. R., & Schäfer, H. (2008) · International Journal of Cancer · doi:10.1002/ijc.23703 · Cited by 71
The histone deacetylase inhibitor, romidepsin, suppresses cellular immune functions of cutaneous T‐cell lymphoma patients
Kelly‐Sell, M. J., Kim, Y. H., Straus, S., Benoit, B. M., Harrison, C., Sutherland, K., Armstrong, R. J., Weng, W., Showe, L. C., Wysocka, M., et al. (2012) · American Journal of Hematology · doi:10.1002/ajh.23112 · Cited by 70
Shot-gun proteomic analysis of mitochondrial D-loopDNA bindingproteins: identification of mitochondrial histones
Choi, Y.-S., Jeong, J. H., Min, H., Jung, H.-J., Hwang, D., Lee, S., & Pak, Y. K. (2011) · Molecular BioSystems · doi:10.1039/c0mb00277a · Cited by 70
New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs
Schouten, M., Buijink, M. R., Lucassen, P. J., & Fitzsimons, C. P. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00025 · Cited by 70
The methylation status of cytosines in a τ gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex
Tohgi, H., Utsugisawa, K., Nagane, Y., Yoshimura, M., Ukitsu, M., & Genda, Y. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00731-4 · Cited by 70
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration
Kanthasamy, A. G., Jin, H., Anantharam, V., Sondarva, G. V., Rangasamy, V., Rana, A., & Kanthasamy, A. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.01.011 · Cited by 70
The therapeutic role of creatine in Huntington's disease
Ryu, H., Rosas, H. D., Hersch, S. M., & Ferrante, R. J. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.04.008 · Cited by 69
Antibodies specific for N6‐methyladenosine react with intact snRNPs U2 and U4/U6
Bringmann, P., & Lührmann, R. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81512-0 · Cited by 69
Patterns of alpha-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease
van de Berg, W. D. J., Hepp, D. H., Dijkstra, A. A., Rozemüller, A. J. M., Berendse, H. W., & Foncke, E. M. J. (2011) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70011-6 · Cited by 69
Dietary Supplementation with S-Adenosyl Methionine Delayed Amyloid-β and Tau Pathology in 3xTg-AD Mice
Lee, S., Lemere, C. A., Frost, J. L., & Shea, T. B. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111025 · Cited by 68
Self-citation
Reduced Rates of Gene Loss, Gene Silencing, and Gene Mutation in Dnmt1-Deficient Embryonic Stem Cells
Chan, M. F., van Amerongen, R., Nijjar, T., Cuppen, E. P. J. G., Jones, P. A., & Laird, P. W. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.22.7587-7600.2001 · Cited by 68
Accurate and efficientN-6-adenosine methylation in spliceosomal U6 small Nucelar RNA by HeLa cell extractin vitro
Shimba, S., Bokar, J. A., ROTTMAN, F. M., & Reddy, R. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.13.2421 · Cited by 68
Environmental exposure and mitochondrial epigenetics: study design and analytical challenges
Byun, H.-M., & Baccarelli, A. A. (2014) · Human Genetics · doi:10.1007/s00439-013-1417-x · Cited by 68
RNA as the substrate for epigenome‐environment interactions
Mattick, J. S. (2010) · BioEssays · doi:10.1002/bies.201000028 · Cited by 67
Inactive DNMT3B Splice Variants Modulate De Novo DNA Methylation
Gordon, C. A., Hartono, S. R., & Chedin, F. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069486 · Cited by 67
A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease
Thomas, B., Matson, S. A., Chopra, V., Sun, L., Sharma, S., Hersch, S. M., Rosas, H. D., Scherzer, C. R., Ferrante, R. J., & Matson, W. R. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.01.035 · Cited by 67
Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body Disease
de Boni, L., Tierling, S., Roeber, S., Walter, J., Giese, A., & Kretzschmar, H. A. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-011-8163-9 · Cited by 67
New Criteria for Alzheimer Disease and Mild Cognitive Impairment
Budson, A. E., & Solomon, P. R. (2012) · The Neurologist · doi:10.1097/nrl.0b013e31826a998d · Cited by 65
Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p.Ala53Thr alleles in Parkinson disease
Voutsinas, G. E., Stavrou, E. F., Karousos, G., Dasoula, A., Papachatzopoulou, A., Syrrou, M., Verkerk, A. J. M. H., van der Spek, P. J., Patrinos, G. P., Stöger, R. J., et al. (2010) · Human Mutation · doi:10.1002/humu.21248 · Cited by 64
Depolarization induces downregulation of DNMT1 and DNMT3 in primary cortical cultures
Sharma, R. P., Tun, N., & Grayson, D. R. (2008) · Epigenetics · doi:10.4161/epi.3.2.6103 · Cited by 63
Pharmacogenomics and therapeutic prospects in Alzheimer’s disease
Cacabelos, R. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.12.1967 · Cited by 63
Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease
Nuutinen, T., Suuronen, T., Kauppinen, A., & Salminen, A. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.03.041 · Cited by 63
Molecular insights into Parkinson's disease
Thomas, B., & Beal, M. F. (2011) · F1000 Medicine Reports · doi:10.3410/m3-7 · Cited by 62
The Role of 5-Hydroxymethylcytosine in Aging and Alzheimer’s Disease: Current Status and Prospects for Future Studies
van den Hove, D., Chouliaras, L., & Rutten, B. P. F. (2012) · Current Alzheimer Research · doi:10.2174/156720512800618008 · Cited by 62
Self-citation
Modified nucleotides in T1 RNase oligonucleotides of 18S ribosomal RNA of the Novikoff hepatoma
Choi, Y. C., & Busch, H. (1978) · Biochemistry · doi:10.1021/bi00606a015 · Cited by 62
Methylation of P16, P21, P27, RB1 and P53 genes in odontogenic keratocysts
Moreira, P. R., Guimarães, M. M., Guimarães, A. L. S., Diniz, M. G., Gomes, C. C., Brito, J. A. R., & Gomez, R. S. (2008) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2008.00718.x · Cited by 62
HBP1-Mediated Transcriptional Regulation of DNA Methyltransferase 1 and Its Impact on Cell Senescence
Pan, K., Chen, Y., Roth, M. M., Wang, W., Wang, S., Yee, A. S., & Zhang, X. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00637-12 · Cited by 61
Epigenesis and Epigenetics
Müller, G. B., & Olsson, L. (2006) · Harvard University Press eBooks · doi:10.2307/j.ctv228vqrq.21 · Cited by 59
APOBEC3 proteins and reverse transcription
Aguiar, R. S., & Peterlin, B. M. (2008) · Virus Research · doi:10.1016/j.virusres.2007.12.022 · Cited by 58
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus
Prado, L., Lombó, F., Braña, A. F., Méndez, C., Rohr, J., & Salas, J. A. (1999) · Molecular and General Genetics MGG · doi:10.1007/s004380050960 · Cited by 58
High-Capacity Adenoviral Vector-Mediated Reduction of Huntingtin Aggregate Load In Vitro and In Vivo
Huang, B., Schiefer, J., Saß, C., Landwehrmeyer, G. B., Kosinski, C. M., & Kochanek, S. (2007) · Human Gene Therapy · doi:10.1089/hum.2006.160 · Cited by 57
Clusterin is epigenetically regulated in prostate cancer
Rauhala, H. E., Porkka, K. P., Saramäki, O. R., Tammela, T. L. J., & Visakorpi, T. (2008) · International Journal of Cancer · doi:10.1002/ijc.23658 · Cited by 57
NMR-Based Metabonomic Investigations into the Metabolic Profile of the Senescence-Accelerated Mouse
Jiang, N., Yan, X., Zhou, W., Zhang, Q., Chen, H., Zhang, Y., & Zhang, X. (2008) · Journal of Proteome Research · doi:10.1021/pr800439b · Cited by 56
Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons
Tian, F., Marini, A. M., & Lipsky, R. H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05175.x · Cited by 55
Histone Decacetylase Inhibitors Prevent Mitochondrial Fragmentation and Elicit Early Neuroprotection against MPP +
Zhu, M., Li, W., & Lü, C. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12217 · Cited by 55
Lowering homocysteine levels with folic acid and B-vitamins do not reduce early atherosclerosis, but could interfere with cognitive decline and Alzheimer’s disease
Cacciapuoti, F. (2012) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-012-0856-x · Cited by 55
Mice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity
Duclot, F., Meffre, J., Jacquet, C., Gongora, C., & Maurice, T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.055 · Cited by 55
Natural Antisense Transcripts
Werner, A. (2005) · RNA Biology · doi:10.4161/rna.2.2.1852 · Cited by 55
Evaluation of the poly(ADP‐ribose) polymerase‐1 gene variants in Alzheimer's disease
Liu, H., Lin, W., Wu, B., Liu, S. R., Wang, W., Tsai, C., Lee, C., & Tsai, F. (2010) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.20379 · Cited by 54
Striatal specificity of gene expression dysregulation in Huntington's disease
Thomas, E. A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21046 · Cited by 53
Histone Deacetylase 2 in the Mouse Hippocampus: Attenuation of Age- Related Increase by Caloric Restriction
Chouliaras, L., van den Hove, D., Kenis, G., van Draanen, M., Hof, P. R., van Os, J., Steinbusch, H. W. M., Schmitz, C., & Rutten, B. P. F. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310080009 · Cited by 53
Self-citation
High Expression of Apolipoprotein E mRNA in the Brains with Sporadic Alzheimer’s Disease
Yamagata, K., Urakami, K., Ikeda, K., Ji, Y., Adachi, Y., Arai, H., Sasaki, H., Sato, K., & Nakashima, K. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051236 · Cited by 53
Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase
Matsubara, M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh859 · Cited by 52
TET proteins: on the frenetic hunt for new cytosine modifications
Delatte, B., & Fuks, F. (2013) · Briefings in Functional Genomics · doi:10.1093/bfgp/elt010 · Cited by 51
Structural basis of DNA recognition by anticancer antibiotics, chromomycin A3, and mithramycin: Roles of minor groove width and ligand flexibility
Chakrabarti, S., Bhattacharyya, D., & Dasgupta, D. (2000) · Biopolymers · doi:10.1002/1097-0282(2000)56:2 · Cited by 51
Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca2+ signaling in Huntington’s disease
Lee, J.-H., Hwang, Y. J., Shin, J.-Y., Lee, W., Wie, J., Kim, K. Y., Lee, M. Y., Hwang, D., Ratan, R. R., Pae, A. N., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1103-z · Cited by 50
Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus
Akram, A., Schmeidler, J., Katsel, P., Hof, P. R., & Haroutunian, V. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.006 · Cited by 50
Self-citation
Epigenetics-Based Therapeutics for Neurodegenerative Disorders
Xu, Z., Li, H., & Jin, P. (2012) · Current Geriatrics Reports · doi:10.1007/s13670-012-0027-0 · Cited by 49
Emerging roles of epigenetic mechanisms in Parkinson’s disease
Habibi, E., Masoudi‐Nejad, A., Abdolmaleky, H. M., & Haggarty, S. J. (2011) · Functional & Integrative Genomics · doi:10.1007/s10142-011-0246-z · Cited by 48
Age-related gene-specific changes of A-to-I mRNA editing in the human brain
Nicholas, A., de Magalhaes, J. P., Kraytsberg, Y., Richfield, E. K., Levanon, E. Y., & Khrapko, K. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.06.001 · Cited by 48
Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2′-deoxycytidine in Neuro-2a cells
Ishimaru, N., Fukuchi, M., Hirai, A., Chiba, Y., Tamura, T., Takahashi, N., Tabuchi, A., Tsuda, M., & Shiraishi, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.139 · Cited by 47
Regulation of transposable elements in maize
Lisch, D. R. (2012) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2012.07.001 · Cited by 46
Biological significance of protein modifications in aging and calorie restriction
Nakamura, A., Kawakami, K., Kametani, F., Nakamoto, H., & Goto, S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05374.x · Cited by 46
Pharmacogenetic Basis for Therapeutic Optimization in Alzheimer’s Disease
Cacabelos, R. (2007) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256262 · Cited by 45
Epigenetic control on cell fate choice in neural stem cells
Hu, X.-L., Wang, Y., & Shen, Q. (2012) · Protein & Cell · doi:10.1007/s13238-012-2916-6 · Cited by 45
The Mitochondrial Epigenome: a Role in Alzheimer’s Disease?
Devall, M. A. M., Mill, J. S., & Lunnon, K. (2014) · Epigenomics · doi:10.2217/epi.14.50 · Cited by 45
Monoallele deletion of CBP leads to pericentromeric heterochromatin condensation through ESET expression and histone H3 (K9) methylation
Lee, J.-H., Hagerty, S. W., Cormier, K., Kim, J., Kung, A. L., Ferrante, R. J., & Ryu, H. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn067 · Cited by 45
Epigenetic Regulation of Mammalian Genomes by Transposable Elements
Huda, A., & Jordan, I. K. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05007.x · Cited by 45
A DNA Methylation Study of the Amyloid Precursor Protein Gene in Several Brain Regions from Patients with Familial Alzheimer Disease
Brohede, J., Rinde, M., Winblad, B. G., & Graff, C. (2010) · Journal of Neurogenetics · doi:10.3109/01677063.2010.503978 · Cited by 45
Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease (Erratum)
Chouliaras, L., Sierksma, A. S. R., Kenis, G., Prickaerts, J., Lemmens, M. A. M., Brasnjevic, I., van Donkelaar, E. L., Martínez‐Martínez, P., Losen, M. H., Baets, M. H. D., et al. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/356862 · Cited by 44
Self-citation
A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1
Müller, T., Schrötter, A., Looße, C., Pfeiffer, K., Theiß, C., Kauth, M., Meyer, H. E., & Marcus, K. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2012.07.017 · Cited by 44
Mitochondrial DNA: a blind spot in neuroepigenetics
Manev, H., Dzitoyeva, S., & Chen, H. (2012) · BioMolecular Concepts · doi:10.1515/bmc-2011-0058 · Cited by 44
Association analysis of 528 intra‐genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease
Morgan, A. R., Hamilton, G., Turic, D., Jehu, L., Harold, D. H., Abraham, R., Hollingworth, P., Moskvina, V., Brayne, C., Rubinsztein, D. C., et al. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30670 · Cited by 44
Dysfunction of Wild-Type Huntingtin in Huntington disease
Cattaneo, E. F. (2003) · Physiology · doi:10.1152/nips.01410.2002 · Cited by 44
Alterations in Tau Protein Metabolism during Normal Aging
Mukaetova-Ladinska, E., Harrington, C. R., Roth, M., & Wischik, C. M. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106861 · Cited by 43
Toward an integrated genetic and epigenetic approach to Alzheimer's disease
Mill, J. S. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.10.021 · Cited by 43
Treatment of Paget's Disease of Bone with Mithramycin
Ryan, W. G. (1977) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-197709000-00012 · Cited by 43
Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer’s disease
Liu, R., Lei, J. X., Luo, C., Lan, X., Chi, L., Deng, P., Lei, S., Ghribi, O., & Liu, Q. Y. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.007 · Cited by 42
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents
Blanco, G., Fu, H., Méndez, C., Khosla, C., & Salas, J. A. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90262-8 · Cited by 42
Loss of caspase-1 gene expression in human gastric carcinomas and cell lines
Jee, C. D., Lee, H. J., Bae, S., Han, Y., Lee, Y. J., Rho, M., & Kim, W. H. (2005) · International Journal of Oncology · doi:10.3892/ijo.26.5.1265 · Cited by 42
Alzheimer's Disease Modeling: Ups, Downs, and Perspectives for Human Induced Pluripotent Stem Cells
Wojda, U., & Kuźnicki, J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121984 · Cited by 40
Using non-coding small RNAs to develop therapies for Huntington's disease
Zhang, Y., & Friedlander, R. M. (2011) · Gene Therapy · doi:10.1038/gt.2011.170 · Cited by 39
Caspase inhibition attenuates accumulation of β-amyloid by reducing β-secretase production and activity in rat brains after stroke
Xiong, M., Zhang, T., Zhang, L., Lu, S.-D., Huang, Y.-L., & Sun, F. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.08.007 · Cited by 39
An Intrinsically Disordered Region of the Acetyltransferase p300 with Similarity to Prion-Like Domains Plays a Role in Aggregation
Kirilyuk, A., Shimoji, M., Catania, J., Sahu, G., Pattabiraman, N., Giordano, A., Albanese, C., Mocchetti, I., Toretsky, J. A., Uversky, V. N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048243 · Cited by 38
Concurrent isolation and characterization of oligodendrocytes, microglia and astrocytes from adult human spinal cord
Whittemore, S. R., Sanon, H. R., & Wood, P. M. (1993) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(93)90064-k · Cited by 37
Epigenetic changes and non-coding expanded repeats
Nakamori, M., & Thornton, C. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.02.004 · Cited by 36
Induction of clusterin/apoJ expression by histone deacetylase inhibitors in neural cells
Nuutinen, T., Suuronen, T., Kyrylenko, S., Huuskonen, J., & Salminen, A. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.07.007 · Cited by 36
Select non-coding RNA in blood components provide novel clinically accessible biological surrogates for improved identification of traumatic brain injury in OEF/OIF Veterans.
Pasinetti, G. M., Ho, L., Dooley, C., Abbi, B., & Lange, G. (2012) · Europe PMC (PubMed Central) · Cited by 36
Potent neuroprotective effects of novel structural derivatives of valproic acid: Potential roles of HDAC inhibition and HSP70 induction
Leng, Y., Marinova, Z., Reis-Fernandes, M. A., Nau, H., & Chuang, D. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.04.013 · Cited by 36
Neurotoxicity of MPTP
Fukuda, T. (2001) · Neuropathology · doi:10.1046/j.1440-1789.2001.00402.x · Cited by 35
Study of Methylation Levels of Parkin Gene Promoter in Parkinson's Disease Patients
Cai, M., Tian, J., Zhao, G., Luo, W. F., & Zhang, B. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2011.580866 · Cited by 35
Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron
Yoon, S. Y., Choi, H., Choi, J. E., Sul, C. A., Choi, J. M., & Kim, D. H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.09.060 · Cited by 35
dTip60 HAT Activity Controls Synaptic Bouton Expansion at the Drosophila Neuromuscular Junction
Sarthi, J. B., & Elefant, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026202 · Cited by 34
Toxins and Parkinson's disease: MPTP parkinsonism in humans and animals.
Kopin, I. J. (1987) · PubMed · Cited by 34
Alzheimer’s Disease: Current Status of Etiopathogenesis and Therapeutic Strategies
Kh, M. I., & Kassem, L. A. A. (2011) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2011.257.272 · Cited by 33
MicroRNA-323-3p with clinical potential in rheumatoid arthritis, Alzheimer's disease and ectopic pregnancy
Xu, T., Li, L., Huang, C., Li, X., Peng, Y., & Li, . (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.855201 · Cited by 32
Suicidal function of DNA methylation in age-related genome disintegration
Mazin, A. L. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.04.005 · Cited by 32
Identification of phenylbutyrate-generated metabolites in Huntington disease patients using parallel liquid chromatography/electrochemical array/mass spectrometry and off-line tandem mass spectrometry
Ebbel, E. N., Leymarie, N., Schiavo, S., Sharma, S., Gevorkian, S., Hersch, S. M., Matson, W. R., & Costello, C. E. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.01.010 · Cited by 32
Amyloid precursor protein expression is induced by tumor necrosis factor α in 3T3‐L1 adipocytes
Sommer, G., Kralisch, S., Lipfert, J., Weise, S., Krause, K., Jeßnitzer, B., Lössner, U., Blüher, M., Stümvoll, M., & Faßhauer, M. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22382 · Cited by 32
Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease
Chouliaras, L., Sierksma, A. S. R., Kenis, G., Prickaerts, J., Lemmens, M. A. M., Brasnjevic, I., van Donkelaar, E. L., Martínez‐Martínez, P., Losen, M. H., Baets, M. H. D., et al. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/859101 · Cited by 30
Self-citation
Differential acetylation of core histones in rat cerebral cortex neurons during development and aging
Piña, B., Martı́nez, P., & Suau, P. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14099.x · Cited by 30
Pathogenesis and Management of Cancer-Associated Hypercalcaemia
Ralston, S. H. (1991) · Springer eBooks · doi:10.1007/978-1-4471-3254-7_8 · Cited by 30
RNA Interference from Biology to Therapeutics
Howard, K. A. (2012) · Advances in delivery science and technology · doi:10.1007/978-1-4614-4744-3 · Cited by 29
Mithramycin Therapy in Testicular Cancer
Kennedy, B. J. (1972) · The Journal of Urology · doi:10.1016/s0022-5347(17)61046-2 · Cited by 29
Protein abnormalities in Huntington's chorea
Iqbal, K., Tellez-Nagel, I., & Grunke-Iqbal, I. (1974) · Brain Research · doi:10.1016/0006-8993(74)90527-7 · Cited by 28
Most human Alu and Murine B1 repeats are unique
Umylny, B., Presting, G. G., Efird, J. T., Klimovitsky, B. I., & Ward, W. S. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21278 · Cited by 27
Systematic difference in the methylation of ribosomal ribonucleic acid from gram-positive and gram-negative bacteria
Tanaka, T., & Weisblum, B. (1975) · Journal of Bacteriology · doi:10.1128/jb.123.2.771-774.1975 · Cited by 26
Immunospecific retention of oligonucleotides possessing N6-methyladenosine and 7-methylguanosine.
Munns, T. W., Sims, H. F., & Liszewski, M. K. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40477-7 · Cited by 26
Methylation of chromosomal proteins and DNA of rat brain and its modulation by estradiol and calcium during aging
Thakur, M. K., & Kanungo, M. S. (1981) · Experimental Gerontology · doi:10.1016/0531-5565(81)90052-8 · Cited by 26
Isolation and characterization of the CD133+ precursors from the ventricular zone of human fetal brain by magnetic affinity cell sorting
Yu, S., Zhang, J., Zhao, C., Zhang, H., & Xu, Q. (2004) · Biotechnology Letters · doi:10.1023/b:bile.0000035484.64499.ac · Cited by 26
Epigenetic regulation of estrogen receptor beta expression in the rat cortex during aging
Westberry, J. M., Trout, A. L., & Wilson, M. E. (2011) · Neuroreport · doi:10.1097/wnr.0b013e328346e1cf · Cited by 24
MicroRNAs and Molecular Mechanisms of Neurodegeneration
Bicchi, I., Morena, F., Montesano, S., Polidoro, M., & Martino, S. (2013) · Genes · doi:10.3390/genes4020244 · Cited by 23
Induced pluripotent stem cells and promises of neuroregenerative medicine
Verma, A. K., & Verma, N. (2011) · Neurology India · doi:10.4103/0028-3886.84337 · Cited by 23
Characterization of Induced Neural Progenitors from Skin Fibroblasts by a Novel Combination of Defined Factors
Tian, C., Liu, Q., Ma, K., Wang, Y., Chen, Q., Ambroz, R., Klinkebiel, D. L., Li, Y., Huang, Y., Ding, J., et al. (2013) · Scientific Reports · doi:10.1038/srep01345 · Cited by 22
Emerging bioinformatics approaches for analysis of NGS-derived coding and non-coding RNAs in neurodegenerative diseases
Guffanti, A., Simchovitz, A., & Soreq, H. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00089 · Cited by 22
Quantitative assessment of RUNX3 methylation in neoplastic and non‐neoplastic gastric epithelia using a DNA microarray
So, K., Tamura, G., Honda, T., Homma, N., Endoh, M., Togawa, N., Nishizuka, S., & Motoyama, T. (2006) · Pathology International · doi:10.1111/j.1440-1827.2006.02010.x · Cited by 21
Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's disease
Caesar, I., & Gandy, S. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-36 · Cited by 20
[DNA-methylase activities from animal mitochondria and nuclei: different specificity of DNA methylation].
Kudriashova, I. B., Kirnos, M. D., & Bf, V. (1976) · PubMed · Cited by 19
Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3β and histone deacetylase
Huang, H., Lin, S., Chen, W.-F., Li, K.-W., Kuo, J., & Wang, M.-J. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.09.010 · Cited by 19
Non-coding RNA detection methods combined to improve usability, reproducibility and precision
Raasch, P., Schmitz, U., Patenge, N., Vera, J., Kreikemeyer, B., & Olaf Wolkenhauer, A. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-491 · Cited by 19
Blood Chromatin as a Biosensor of the Epigenetic Milieu: A Tool for Studies in Living Psychiatric Patients
Sharma, R. P. (2012) · Epigenomics · doi:10.2217/epi.12.46 · Cited by 16
Region-specific neuron and synapse loss in the hippocampus of APPSL/PS1 knock-in mice
Brasnjevic, I., Lardenoije, R., Schmitz, C., van der Kolk, N. M., Dickstein, D. L., Takahashi, H., Hof, P. R., Steinbusch, H. W. M., & Rutten, B. P. F. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0111-8 · Cited by 16
Self-citation
P3‐260: Epigenetic modification in a monozygotic twin with Alzheimer's disease
Ryu, H., Barrup, M., Kowall, N. W., & McKee, A. C. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.1828 · Cited by 16
A-to-I RNA editing does not change with age in the healthy male rat brain
Holmes, A. P., Wood, S. H., Merry, B. J., & de Magalhães, J. P. (2013) · Biogerontology · doi:10.1007/s10522-013-9433-8 · Cited by 16
P2‐146: Epigenetic changes related to beta‐amyloid‐implications for Alzheimer's disease
Lithner, C. U., Hernandez, C. M., Nordberg, A. K., & Sweatt, J. D. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.457 · Cited by 16
Caloric restriction and aging but not overexpression of SOD1 affect hippocampal volumes in mice
Rutten, B. P. F., Brasnjevic, I., Steinbusch, H. W. M., & Schmitz, C. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.08.002 · Cited by 15
Self-citation
Cell cycle‐dependent transcription of cyclin B2 is influenced by DNA methylation but is independent of methylation in the CDE and CHR elements
Tschöp, K., & Engeland, K. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06045.x · Cited by 15
Altered DNA methylation and RNA splicing could be key mechanisms in Huntington disease
Wood, H. B. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.23 · Cited by 14
DNA Methylation and Alzheimer’s Disease
van Groen, T. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0639-7_17 · Cited by 10
RNA as the substrate for epigenome‐environment interactions
Mattick, J. S. (2010) · BioEssays · doi:10.1002/bies.201090026 · Cited by 10
RNAi Therapeutic Delivery by Exosomes
Lakhal, S., Andaloussi, S. E., O’Loughlin, A. J., Li, J., & Wood, M. M. J. (2012) · Advances in delivery science and technology · doi:10.1007/978-1-4614-4744-3_9 · Cited by 8

Research works printed but not linked: 2

Alarcón, 2004, Chromatin acetylation, memory, and LTP are impaired in CBP+/− mice: a model for the cognitive deficit in Rubinstein–Taybi syndrome and its amelioration, Neuron, 42, 947, 10.1016/j.neuron.2004.05.021 · DOI · Paper page
Lovestone, 1997, The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes, Neuroscience, 78, 309

Sorted by citations

How neuroinflammation contributes to neurodegeneration
Ransohoff, R. M. (2016) · Science · doi:10.1126/science.aag2590 · Cited by 1,967
Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics
Tiwari, S., Atluri, V., Kaushik, A., Yndart, A., & Nair, M. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s200490 · Cited by 1,308
Predicting Age Using Neuroimaging: Innovative Brain Ageing Biomarkers
Cole, J. H., & Franke, K. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.001 · Cited by 939
β-Hydroxybutyrate: A Signaling Metabolite
Newman, J. C., & Verdin, E. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064916 · Cited by 872
“The broader role of epigenetics in cognition and neurodegenerative disease has been reviewed (67, 68, 100).”
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Milošević, N. J., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., et al. (2016) · Biomolecules · doi:10.3390/biom6010006 · Cited by 730
Self-citation

See all 390

Authors: Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., & Rutten, B. P. F.
Affiliations: Maastricht University (NL)
University of Lausanne (CH)
Banner Sun Health Research Institute (US)
Brigham and Women's Hospital (US)
Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Rutten, Bart P.F.
ORCID: Lardenoije, Roy
Iatrou, Artemis
Kompotis, Konstantinos
Steinbusch, Harry W.M.
Mastroeni, Diego
Coleman, Paul
Lemere, Cynthia A.
Hof, Patrick R.
Rutten, Bart P.F.
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2015-08
Volume: 131
Pages: 21-64
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2015.05.002
PMC: PMC6477921
OpenAlex: W648684004
Cited by: 381
References: 770
Citations by year: 2026: 12 · 2025: 29 · 2024: 28 · 2023: 28 · 2022: 32 · 2021: 47 · 2020: 30 · 2019: 42 · 2018: 39 · 2017: 43 · 2016: 38 · 2015: 11
FWCI: 4.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion)
Funders: Internationale Stichting Alzheimer Onderzoek (07551, 11532, 09552, 13515)
Netherlands Organization for Scientific Research (916.11.086)
National Institutes of Health (P50 AG005138)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: epigenetics, aging, neurodegeneration, DNA methylation, DNA demethylation, chromatin remodeling, non-coding RNA, Alzheimer's disease, Parkinson's disease, Huntington's disease, epigenetic therapy, gene expression regulation, histone modifications
MeSH terms: Aging, Animals, Humans, DNA Methylation, Neurodegenerative Diseases, Genetic Predisposition to Disease, RNA, Untranslated, Epigenesis, Genetic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The epigenetics of aging and neurodegeneration

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks