Mitochondrial Dysfunction in Bipolar Disorder: Lessons from Brain Imaging and Molecular Markers
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BDNF, oxidative stress, and inflammation tend to be abnormal among individuals with multiple mood episodes and correlate with length of illness.
“there is also evidence suggesting that BDNF, oxidative stress, and inflammation tend to be abnormal among individuals with multiple mood episodes and correlate with length of illness [51, 66, 67].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [67]
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Research works printed but not linked: 6
- Leboyer M, Kupfer DJ. Bipolar disor- der: new perspectives in health care and prevention. J Clin Psychiatry. 2010;71:1689-95.
- Kato T, Kato N. Mitochondrial dys- function in bipolar disorder. Bipolar Disord. 2000;2:180-90.
- Adam-Vizi V, Chinopoulos C. Bioener- getics and the formation of mitochon- drial reactive oxygen species. Trends Pharmacol Sci. 2006;27:639-45.
- Lenaz G, D'Aurelio M, Merlo Pich M, et al. Mitochondrial bioenerge- tics in aging. Biochim Biophys Acta. 2000;1459:397-404.
- Savas HA, Gergerlioglu HS, Gurel A, et al. [Increased xanthine oxidase and malondialdehyde levels in euthymic bi- polar patients]. Klinik Psikiyatri Dergisi. 2005;8:180-5. [Artículo en turco].
- Dager SR, Friedman SD, Parow A, et al. Brain metabolic alterations in medica- tion-free patients with bipolar disorder. Arch Gen Psychiatry. 2004;61:450-8.
Cited by
Sorted by citations
Behr, G. A., Moreira, J. C. F., & Frey, B. N. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/609421 · Cited by 205 · see citing works
Self-citation
- Authors
- Minuzzi, L., Behr, G. A., Moreira, J. C. F., & Frey, B. N.
- Affiliations
- St. Joseph’s Healthcare Hamilton (CA)
- Ministry of Education (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Frey, Benicio N.
- Venue
- Revista Colombiana de Psiquiatría
- Publisher
- Elsevier BV
- Published
- 2011
- Volume
- 40
- Pages
- 166S-182S
- ISSN
- 0034-7450 (ISSN-L)
- OpenAlex
- W2064354337
- Cited by
- 7
- References
- 89
- Citations by year
- 2025: 1 · 2021: 1 · 2016: 1 · 2014: 3 · 2012: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.redalyc.org
- Locations
- Revista Colombiana de Psiquiatría (publishedVersion)
- Redalyc (Universidad Autónoma del Estado de México) (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- bipolar disorder, mitochondrial dysfunction, brain energy metabolism, glucose metabolism, lactate, oxidative stress, electron transport chain, anaerobic glycolysis, prefrontal cortex, amygdala, hippocampus, postmortem brain, cerebrospinal fluid biomarkers, neuroinflammation, neurodegeneration, cognitive impairment, mood disorders, neuroplasticity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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