α-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression
Abstract
This study investigated the antidepressant potential of alpha-tocopherol, the most active and abundant form of vitamin E, in the forced swim test (FST) and tail suspension test (TST). The acute oral treatment with alpha-tocopherol at the doses of 30 and 100mg/kg reduced the immobility time in the FST and in the TST. A single i.c.v. administration of alpha-tocopheryl phosphate, a water-soluble analogue of alpha-tocopherol, also reduced the immobility time in the FST (0.1 and 1 nmol/site) and in the TST (0.1 nmol/site). In addition, the long-term treatment (28 days) with alpha-tocopherol (10mg/kg, p.o.) significantly reduced the immobility time in the FST. Moreover, a subeffective dose of alpha-T (10mg/kg, p.o.) potentiated the effect of fluoxetine (10mg/kg, p.o.) in the FST. The long-term treatment with alpha-T was able to increase the glutathione (GSH) antioxidant defense system, while the acute treatment was not. The long-term treatment with alpha-tocopherol (10mg/kg) increased the GSH levels in the hippocampus and in the prefrontal cortex and increased the glutathione peroxidase and glutathione reductase activity in the hippocampus (10mg/kg) and in the prefrontal cortex (10-100mg/kg). The long-term treatment with fluoxetine (10mg/kg, p.o.), a positive control, was also able to increase the GSH levels in the hippocampus, but failed to alter the activity of both enzymes. Besides the specific antidepressant-like effect, long-term, but not the acute treatment with alpha-T, especially in the doses that produced an antidepressant-like effect (10mg/kg), improved the antioxidant defenses in the mouse hippocampus and prefrontal cortex, two structures closely implicated in the pathophysiology of depression.
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Alpha-tocopherol administration produces antidepressant-like effects in animal models of depression.
“Additionally, alpha-tocopherol (vitamin E) administration produced antidepressant-like effects in animal models of depression.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [19]
Chronic fluoxetine treatment increases GSH in both hippocampus and prefrontal cortex of female mice.
“whereas chronic treatment increased GSH in both hippocampus and prefrontal cortex of female mice [19].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [19]
Long-term treatment with alpha-tocopherol enhances antioxidant defences in the mouse hippocampus and prefrontal cortex.
“Along with antidepressant-like effects, long-term treatment with alpha-tocopherol enhanced antioxidant defences in the mouse hippocampus and prefrontal cortex, two structures closely implicated in the pathophysiology of depression [19].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [19]
Acute fluoxetine treatment reduces GPx activity in the hippocampus of female mice.
“acute fluoxetine treatment reduced GPx activity in the hippocampus”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [19]
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第110回日本精神神経学会学術総会 教育講演 宗教(カトリシズム,プロテスタンティズム,仏教)が医療に果たした役割 : わが国の緩和医療の今後を考えながら
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- Authors
- Lobato, K. R., Cardoso, C. C., Binfaré, R. W., Budni, J., Wagner, C. L. R., Brocardo, P. S., de Souza, L. F., Brocardo, C., Flesch, S., Freitas, A. E., Dafré, A. L., & Rodrigues, A. L. S.
- Affiliations
- Universidade Federal de Santa Catarina (BR)
- Corresponding author
- Rodrigues, Ana Lúcia S.
- ORCID
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 209
- Issue
- 2
- Pages
- 249-259
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2055517339
- Cited by
- 67
- References
- 62
- Citations by year
- 2025: 4 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 7 · 2013: 10 · 2012: 8
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- alpha-tocopherol, vitamin E, antidepressant-like effects, depression, forced swim test, tail suspension test, intracerebroventricular administration, glutathione, antioxidant defense, glutathione peroxidase, glutathione reductase, hippocampus, prefrontal cortex, immobility time
- MeSH terms
- Analysis of Variance, Animals, Antidepressive Agents, Depressive Disorder, Disease Models, Animal, Exploratory Behavior, Female, Fluoxetine, Glutathione, Hippocampus, Motor Activity, Swimming, Time Factors, Prefrontal Cortex, Hindlimb Suspension, alpha-Tocopherol, Immobility Response, Tonic, Mice
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