Cited by 67Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchCholinesterase and Neurodegenerative Diseases

The DOI matches its Crossref record; 322 of the 322 references it cites were found in a registry or an index.

The septo-hippocampal system, learning and recovery of function

Niewiadomska, Grazyna, Baksalerska-Pazera, Marta, Riedel, Gernot·2009·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2009.03.039

Open this paper in CoChat — free account

Abstract

We understand this review as an attempt to summarize recent advances in the understanding of cholinergic function in cognition. Such a role has been highlighted in the 1970s by the discovery that dementia patients have greatly reduced cholinergic activity in cortex and hippocampus. A brief anatomical description of the major cholinergic pathways focuses on the basal forebrain and its projections to cortex and hippocampus. From this distinction, compelling evidence suggests that the basal forebrain --> cortex projection regulates the excitability of principal cortical neurons and is thereby critically involved in attention, stimulus detection and memory function, although the biological conditions for these functions are still debated. Similar uncertainties remain for the septo-hippocampal cholinergic system. Although initial lesions of the septum caused memory deficits reminiscent of hippocampal ablations, recent and more refined neurotoxic lesion studies which spared non-cholinergic cells of the basal forebrain failed to confirm these memory impairments in experimental animals despite a near total loss of cholinergic labeling. Yet, a decline in cholinergic markers in aging and dementia still stands as the most central piece of evidence for a link between the cholinergic system and cognition and appear to provide valuable targets for therapeutic approaches.

Integrity signals

Registry

Crossref · 10.1016/j.pnpbp.2009.03.039

Cites

322 of 322 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Items 201–322 of 322

The Potential for Muscarinic Receptor Subtype-Specific Pharmacotherapy for Alzheimer's Disease
McKinney, M., & Coyle, J. T. (1991) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62474-4 · Cited by 77
Chapter 25 Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction
Schliebs, R., Roβner, S., & Bigl, V. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)62109-3 · Cited by 76
Distribution of nerve growth factor‐like immunoreactive neurons in the adult rat brain following colchicine treatment
Conner, J. M., & Varon, S. S. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903260304 · Cited by 76
Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons
O’Brien, T., Svendsen, C. N., Ole Isacson, A., & Sofroniew, M. V. (1990) · Brain Research · doi:10.1016/0006-8993(90)90403-x · Cited by 76
Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys.
Ridley, R. M., Barefoot, H. C., Maclean, C. J., Pugh, P. L., & Baker, H. F. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.2.303 · Cited by 75
Concurrent visualization of choline acetyltransferase-like immunoreactivity and retrograde transport of neocortically injected markers in basal forebrain neurons of cat and rat
Wahle, P., Buchholtz, C. S., Eckenstein, F. P., & Albus, K. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90026-0 · Cited by 75
CHOLINERGIC ‘BLOCKADE’ AS A MODEL OF THE COGNITIVE DEFICITS IN ALZHEIMER'S DISEASE
CHRISTENSEN, H., MALTBY, N., JORM, A. F., CREASEY, H., & BROE, G. A. (1992) · Brain · doi:10.1093/brain/115.6.1681 · Cited by 74 · cited 2×
“These studies were extended and confirmed in rodents (Fibiger et al., 1991) as well as in humans (Christensen et al., 1992; Molchan et al., 1992).”
Septo-hippocampal cholinergic and neurotrophin markers in age-induced cognitive decline
Sugaya, K., Greene, R., Personett, D. A., Robbins, M., Kent, C., Bryan, D., Skiba, E., Gallagher, M., & McKinney, M. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00072-4 · Cited by 74
Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized fisher 344 rats
Armstrong, D. M., Sheffield, R., Buzsáki, G., Chen, K. S., Hersh, L. B., Nearing, B. D., & Gage, F. H. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90104-j · Cited by 73
Retrograde horseradish peroxidase tracing combined with localization of choline acetyltransferase immunoreactivity.
Wainer, B. H., & Rye, D. B. (1984) · Journal of Histochemistry & Cytochemistry · doi:10.1177/32.4.6368680 · Cited by 72
The cytoskeleton in Alzheimer disease
Terry, R. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_12 · Cited by 70
Selective attention in Alzheimer's disease: Characterizing cognitive subgroups of patients
Freed, D. M., Corkin, S., Growdon, J. H., & Nissen, M. J. (1989) · Neuropsychologia · doi:10.1016/0028-3932(89)90022-5 · Cited by 70
Basal forebrain neurons and memory: A biochemical, histological, and behavioral study of differential vulnerability to ibotenate and quisqualate.
Wenk, G. L., Harrington, C. A., Tucker, D. A., Rance, N. E., & al, E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.6.909 · Cited by 69
Differential Regulation of Hippocampal Neurotrophins During Aging in Rats
Narisawa‐Saito, M., & Nawa, H. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67031124.x · Cited by 69
Selective impairment of spatial attention during visual search in Alzheimerʼs disease
Parasuraman, R., Greenwood, P. M., & Alexander, G. E. (1995) · Neuroreport · doi:10.1097/00001756-199510020-00010 · Cited by 67
Age-related sex differences in spatial learning and basal forebrain cholinergic neurons in F344 rats
Veng, L., Granholm, A. C., & Rose, G. M. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00219-1 · Cited by 67
Alterations in excitatory and gabaergic inhibitory connections in hippocampal transplants
Freund, T. F., & Buzsáki, G. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90275-8 · Cited by 66
Decline in visual attention and spatial memory in aged rats
Muir, J. L., Fischer, W., & Björklund, A. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00098-6 · Cited by 65
Intraseptal injections of 192 IgG saporin produce deficits for strategy selection in spatial-memory tasks
Janis, L. S., Glasier, M. M., Fulop, Z., et al. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00078-8 · Cited by 65
Cell loss in the nucleus basalis is related to regional cortical atrophy in Alzheimer's disease
Cullen, K. M., Halliday, G. M., Double, K. L., Brooks, W. S., Creasey, H. M., & Broe, G. A. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00569-6 · Cited by 65
Hippocampal NGF levels are not reduced in the aged Fischer 344 rat
Crutcher, K. A., & Weingartner, J. A. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90072-r · Cited by 64
Age- and Dementia-Associated Impairments in Divided Attention: Psychological Constructs, Animal Models, and Underlying Neuronal Mechanisms
Sarter, M. F., & Turchi, J. N. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000048633 · Cited by 64
Cholinergic neurons within the rat hippocampus: Response to fimbria‐fornix transection
Blaker, S. N., Armstrong, D. M., & Gage, F. H. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902720109 · Cited by 64
Acetylcholine release in the hippocampus and striatum during place and response trainingPreprint
Pych, J. C., Chang, Q., Colon-Rivera, C., Haag, R., & Gold, P. E. (2005) · Learning & Memory · doi:10.1101/lm.33105 · Cited by 64
Acetylcholine release in hippocampus and striatum during testing on a rewarded spontaneous alternation task
Pych, J. C., Chang, Q., Colon-Rivera, C., & Gold, P. E. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.05.001 · Cited by 63
The effects of intrahippocampal BDNF and NGF on spatial learning in aged long evans rats
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Gollub, M., & Wellman, C. L. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815003 · Cited by 63
Interactions between 192-IgG saporin and intraseptal cholinergic and GABAergic drugs: Role of cholinergic medial septal neurons in spatial working memory.
Pang, K. C. H., & Nocera, R. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.2.265 · Cited by 63
Different effects on learning ability after injection of the cholinergic immunotoxin ME20.4IgG-saporin into the diagonal band of Broca, basal nucleus of Meynert, or both in monkeys.
Ridley, R. M., Barefoot, H. C., Maclean, C. J., et al. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.2.303 · Cited by 63
Presynaptic markers of cholinergic function in the rat brain: relationship with age and cognitive status
Baxter, M. G., Frick, K. M., Price, D. L., et al. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00374-1 · Cited by 62
Trans-synaptic stimulation of cortical acetylcholine and enhancement of attentional functions: a rational approach for the development of cognition enhancers
Sarter, M. F., & Bruno, J. P. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)86039-1 · Cited by 62
Neuropathological changes in the nucleus basalis correlate with clinical measures of dementia
Iráizoz, I., Guijarro, J. L., Gonzalo, L. M., & Lacalle, S. D. (1999) · Acta Neuropathologica · doi:10.1007/s004010051068 · Cited by 61
Immunocytochemical identification of cholinergic neurons in the monkey central nervous system using monoclonal antibodies against choline acetyltransferase
Hedreen, J. C., Bacon, S. J., Cork, L. C., Kitt, C. A., Crawford, G. D., Salvterra, P. M., & Price, D. L. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90183-0 · Cited by 60
In vivo and in vitro studies on the regulation of cholinergic neurotransmission in striatum, hippocampus and cortex of aged rats
Consolo, S., Wang, J.-X., Fiorentini, F., et al. (1986) · Brain Research · doi:10.1016/0006-8993(86)90414-2 · Cited by 60
The Critical Role of Cholinergic Basal Forebrain Neurons in Morphological Change and Memory Encoding: A Hypothesis
Woolf, N. J. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0068 · Cited by 60
Involvement of Nerve Growth Factor and Its Receptor in the Regulation of the Cholinergic Function in Aged Rats
Alberch, J., Pérez‐Navarro, E., Arenas, E., & Marsa, J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb06342.x · Cited by 60
Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments
Birthelmer, A., Stemmelin, J., Jackisch, R., & Cassel, J. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00042-x · Cited by 60
Acetylcholine release in the hippocampus: Effects of cholinergic and GABAergic compounds in the medial septal area
Gorman, L. K., Pang, K. C. H., Frick, K. M., Givens, B. S., & Olton, D. S. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90485-5 · Cited by 59
Preservation of Brain Nerve Growth Factor in Mild Cognitive Impairment and Alzheimer Disease
Mufson, E. J., Ikonomović, M. D., Styren, S. D., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1143 · Cited by 59
Trafficking the NGF signal: implications for normal and degenerating neurons
Delcroix, J., Valletta, J. S., Wu, C., Howe, C. L., Lai, C.-F., Cooper, J. D., Belichenko, P. V., Salehi, A., & Mobley, W. C. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)46001-9 · Cited by 58
NGF Level Is Not Decreased in the Serum, Brain-Spinal Fluid, Hippocampus, or Parietal Cortex of Individuals with Alzheimer′s Disease
Murase, K., Nabeshima, T., Robitaille, Y., Quirion, R., Ogawa, M., & Hayashi, K. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1609 · Cited by 57
Interactions between 192-IgG saporin and intraseptal cholinergic and GABAergic drugs: Role of cholinergic medial septal neurons in spatial working memory.
Pang, K. C. H., & Nocera, R. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.2.265 · Cited by 57
Amelioration of cholinergic neurons dysfunction in aged rats depends on the continuous supply of NGF
Niewiadomska, G., Komorowski, S., & Baksalerska-Pazera, M. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00345-1 · Cited by 56
Self-citation
Tuning out irrelevancy? Comments on Solomon's temporal mapping view of the hippocampus.
O'Keefe, J., Nadel, L., & Willner, J. (1979) · Psychological Bulletin · doi:10.1037/0033-2909.86.6.1280 · Cited by 56
5,7‐DHT‐induced hippocampal 5‐HT depletion attenuates behavioural deficits produced by 192 IgG‐saporin lesions of septal cholinergic neurons in the rat
Lehmann, O., Bertrand, F., Jeltsch‐David, H., Morer, M., Lazarus, C., Will, B. E., & Cassel, J. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02037.x · Cited by 56
Subcellular Trafficking of the Amyloid Precursor Protein Gene Family and Its Pathogenic Role in Alzheimer’s Disease
Kins, S., Lauther, N., Szodorai, A., & Beyreuther, K. T. (2006) · Neurodegenerative Diseases · doi:10.1159/000095259 · Cited by 56
Intrastriatal implants of polymer encapsulated cells genetically modified to secrete human nerve growth factor: Trophic effects upon cholinergic and noncholinergic striatal neurons
Kordower, J. H., Chen, E.-Y., Mufson, E. J., et al. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00543-9 · Cited by 56
Cortical oscillations in human medial temporal lobe during wakefulness and all-night sleep
Uchida, S., Maehara, T., Hirai, N., Okubo, Y., & Shimizu, H. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03154-1 · Cited by 56
Basal Forebrain Cholinergic System: A Functional Analysis
Olton, D. S., Markowska, A. L., Voytko, M. L., Givens, B. S., Gorman, L. K., & Wenk, G. L. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0145-6_20 · Cited by 55
Increased amyloid precursor protein expression and serotonergic sprouting following excitotoxic lesion of the rat magnocellular nucleus basalis: neuroprotection by Ca2+ antagonist nimodipine
Harkany, T., Dijkstra, I. M., Oosterink, B. J., Horvath, K. M., Ábrahám, I. M., Keijser, J. N., van der Zee, E. A., & Luiten, P. G. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00296-7 · Cited by 55
Individual differences in cognitive aging: implication of pregnenolone sulfate
Mayo, W., George, O., Darbra, S., Bouyer, J. J., Vallée, M., Darnaudéry, M., Pallarés, M., Lemaire, V., Moal, M. L., Piazza, P., et al. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.006 · Cited by 55
Septo-hippocampal cholinergic system under the discrimination learning task in the rat: a microdialysis study with the dual-probe approach
Yamamuro, Y., Hori, K., Tanaka, J., Iwano, H., & Nomura, M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00290-7 · Cited by 54
The septohippocampal cholinergic system and spatial working memory in the Morris water maze
Frielingsdorf, H., Thal, L. J., & Pizzo, D. P. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.10.008 · Cited by 54
Quantification of human nicotinic acetylcholine receptors with 123I-5IA SPECT.
Mamede, M. H., Ishizu, K., Ueda, M., Mukai, T., Iida, Y., Fukuyama, H., Saga, T., & Saji, H. (2004) · PubMed · Cited by 54
The Effects of Nerve Growth Factor on Spatial Recent Memory in Aged Rats Persist after Discontinuation of Treatment
Frick, K. M., Price, D. L., Koliatsos, V. E., et al. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02543.1997 · Cited by 53
Intrastriatal infusion of nerve growth factor after quinolinic acid prevents reduction of cellular expression of choline acetyltransferase messenger RNA and trkA messenger RNA, but not glutamate decarboxylase messenger RNA
Venero, J. L., Beck, K. D., & Hefti, F. F. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90229-1 · Cited by 53
Association of apolipoprotein J-positive β-amyloid plaques with dystrophic neurites in alzheimer’s disease brain
Martin-Rehrmann, M. D., Hoe, H., Capuani, E. M., & Rebeck, G. W. (2005) · Neurotoxicity Research · doi:10.1007/bf03036452 · Cited by 53
Microdialysis measures of functional increases in ACh release in the hippocampus with and without inclusion of acetylcholinesterase inhibitors in the perfusate
Chang, Q., Savage, L. M., & Gold, P. E. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03765.x · Cited by 51
Detecting effects of donepezil on visual selective attention using signal detection parameters in Alzheimer's disease
Foldi, N. S., White, R. E. C., & Schaefer, L. A. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1319 · Cited by 51
Impaired place navigation in place and matching‐to‐place swimming pool tasks follows both retrosplenial cortex lesions and cingulum bundle lesions in rats
Harker, K. T., & Whishaw, I. Q. (2004) · Hippocampus · doi:10.1002/hipo.10159 · Cited by 51
Effect of cholinesterase inhibitors on Morris water task behavior following lesions of the nucleus basalis magnocellularis.
Dokla, C. P. J., & Thal, L. J. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.6.861 · Cited by 51
Functional interactions of galanin and acetylcholine: Relevance to memory and Alzheimer's disease
Crawley, J. N. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90129-e · Cited by 51
A primate model of Alzheimer's disease
Wenk, G. L. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90127-c · Cited by 48
Severe learning impairment caused by combined immunotoxic lesion of the cholinergic projections to the cortex and hippocampus in monkeys
Ridley, R. M., Pugh, P. L., Maclean, C. J., & Baker, H. F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01641-8 · Cited by 47
Effect of cholinesterase inhibitors on Morris water task behavior following lesions of the nucleus basalis magnocellularis.
Dokla, C. P. J., & Thal, L. J. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.6.861 · Cited by 46
Pharmacological Modulation of Prefrontal Cortical Activity During a Working Memory Task in Young and Older Humans: A PET Study With Physostigmine
Freo, U., Ricciardi, E., Pietrini, P., Schapiro, M. B., Rapoport, S. I., & Furey, M. L. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.11.2061 · Cited by 45
Higher cortical deficits influence attentional processing in dementia with Lewy bodies, relative to patients with dementia of the Alzheimer's type and controls
Bradshaw, J. M. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.090183 · Cited by 45
Signalling organelle for retrograde axonal transport of internalized neurotrophins from the nerve terminal
Sandow, S. L., Heydon, K., Weible, M. W., Aj, R., Bartlett, S. E., & Hendry, I. A. (2000) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2000.00924.x · Cited by 44
Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation
Williams, B., Granholm, A., & Sambamurti, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.11.040 · Cited by 44
Cholinergic binding sites in rat brain: Analysis by age and cognitive status
Smith, T. D., Gallagher, M., & Leslie, F. M. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00156-1 · Cited by 44
Microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine release
Herzog, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00226-9 · Cited by 43
Neurotrophins and Neurodegenerative Diseases: Receptors Stuck in Traffic?
Krüttgen, A., Saxena, S., Evangelopoulos, M., & Weis, J. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.4.340 · Cited by 42
Selective immunolesions of CH4 cholinergic neurons do not disrupt spatial memory in rats
Galani, R., Lehmann, O., Bolmont, T., Aloy, E. M., Bertrand, F., Lazarus, C., Jeltsch‐David, H., & Cassel, J. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00674-1 · Cited by 41
The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation
Kirby, B. P., & Rawlins, J. N. P. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00005-6 · Cited by 40
Hippocampal grafts of acetylcholine-producing cells are sufficient to improve behavioural performance following a unilateral fimbria–fornix lesion
Dickinson-Anson, H., Aubert, I., Gage, F. H., & Fisher, L. J. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00543-5 · Cited by 40
Neurochemical, histopathological and mnemonic effects of combined lesions of the medial septal and serotonin afferents to the hippocampus
Murtha, S. J. E., & Pappas, B. A. (1994) · Brain Research · doi:10.1016/0006-8993(94)90676-9 · Cited by 39
Altered Cellular Distribution of Phospho‐Tau Proteins Coincides with Impaired Retrograde Axonal Transport in Neurons of Aged Rats
Niewiadomska, G., Baksalerska-Pazera, M., & Riedel, G. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1342.026 · Cited by 39
Self-citation
Extensive Lesions of Cholinergic Basal Forebrain Neurons Do Not Impair Spatial Working Memory
Vuckovich, J. A., Semel, M. E., & Baxter, M. G. (2004) · Learning & Memory · doi:10.1101/lm.63504 · Cited by 39
Immunohistochemical localization of choline acetyltransferase in rabbit forebrain
Chao, L., Kan, K.-S. K., & Hung, F.-M. (1982) · Brain Research · doi:10.1016/0006-8993(82)90196-2 · Cited by 38
Relationship of APP mRNA transcripts and levels of NGF and low-affinity NGF receptors to behavioral measures of age-related cognitive dysfunction
Lindner, M. D., Dworetzky, S., Sampson, C., & Loy, R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02282.1994 · Cited by 36
The Role of the Endoplasmic Reticulum in the Accumulation of β-Amyloid Peptide in Alzheimers Disease
Ghribi, O. (2006) · Current Molecular Medicine · doi:10.2174/156652406775574514 · Cited by 36
Cholinergic immunolesions by 192IgG‐saporin—a useful tool to simulate pathogenic aspects of alzheimer's disease
Roßner, S. (1997) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(97)00035-x · Cited by 36
[3H]Ketanserin (Serotonin Type 2) Binding Increases in Rat Cortex Following Basal Forebrain Lesions with Ibotenic Acid
Wenk, G. L., & Engisch, K. L. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb00688.x · Cited by 35
The Effects of rAAV2-Mediated NGF Gene Delivery in Adult and Aged Rats
Wu, K., Meyers, C., Guerra, N. K., King, M. A., & Meyer, E. M. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2003.11.010 · Cited by 34
The acetylcholine innervation of cerebral cortex: new data on its normal development and its fate in the hAPPSW,IND mouse model of Alzheimer?s disease
Descarries, L., Aznavour, N., & Hamel, É. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0186-z · Cited by 34
Effects of THA on passive avoidance retention performance of intact, nucleus basalis, frontal cortex and nucleus basalis + frontal cortex-lesioned rats
Riekkinen, P. J., Sirviö, J., Riekkinen, M., et al. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90041-y · Cited by 33
Cholinergic and GABAergic septo-hippocampal projection neurons in mice: a retrograde tracing study combined with double immunocytochemistry for choline acetyltransferase and parvalbumin
Linke, R., Schwegler, H., & Boldyreva, M. A. (1994) · Brain Research · doi:10.1016/0006-8993(94)90374-3 · Cited by 32
Electrolytic and ibotenic acid lesions of the nucleus basalis magnocellularis interrupt long-term retention, but not acquisition of two-way active avoidance, in rats
Vale-Martı́nez, A., Guillazo‐Blanch, G., Martí‐Nicolovius, M., Nadal, R. A., Arévalo-Garcı́a, R., & Morgado-Bernal, I. (2002) · Experimental Brain Research · doi:10.1007/s00221-001-0917-4 · Cited by 31
Differential participation of the NBM in the acquisition and retrieval of conditioned taste aversion and Morris water maze
Gonzalez, C. L. R., Miranda, M. I., Gutiérrez, H., et al. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00250-3 · Cited by 29
Modulation of acetylcholine release in human cortical slices: Possible implications for Alzheimer's disease
Feuerstein, T. J., & Seeger, W. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00006-5 · Cited by 28
Chapter 29: The neurotrophic hypothesis and the cholinergic basal forebrain projection
Lucidi‐Phillipi, C. A., & Gage, F. H. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)62405-x · Cited by 27
Behavioral Effects of Basal Forebrain Cholinergic Lesions in Young Adult and Aging Rats.
Paban, V., Chambon, C., Jaffard, M., et al. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.4.933 · Cited by 27
Cholinergic and noradrenergic afferents influence the functional properties of the postnatal visual cortex in rats
Siciliano, R., Fornai, F., Bonaccorsi, I., et al. (1999) · Visual Neuroscience · doi:10.1017/s0952523899166045 · Cited by 27
Evoked Acetylcholine Release by Immortalized Brain Endothelial Cells Genetically Modified to Express Choline Acetyltransferase and/or the Vesicular Acetylcholine Transporter
Malo, M., Diebler, M. F., de Carvalho, L. P., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731483.x · Cited by 24
β‐secretase‐cleaved amyloid precursor protein in Alzheimer brain: a morphologic study
Sennvik, K., Bogdanović, N., Volkmann, I., et al. (2004) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2004.tb00267.x · Cited by 23
Compartmental protein expression of Tau, GSK-3β and TrkA in cholinergic neurons of aged rats
Niewiadomska, G., Baksalerska-Pazera, M., Lenarcik, I., & Riedel, G. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0488-4 · Cited by 22
Self-citation
Progression of age‐associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex
Saragovi, H. U. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03479.x · Cited by 21
Age-dependent changes in axonal transport and cellular distribution of Tau 1 in the rat basal forebrain neurons
Niewiadomska, G., & Baksalerska-Pazera, M. (2003) · Neuroreport · doi:10.1097/00001756-200309150-00009 · Cited by 21
Self-citation
Further analysis of the effects of immunotoxic lesions of the basal nucleus of Meynert reveals substantial impairment on visual discrimination learning in monkeys
Ridley, R. M., Baker, H. F., Leow-Dyke, A., & Cummings, R. M. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.02.025 · Cited by 21
Immunochemical and immunohistochemical studies on the specificity of a monoclonal antibody to choline acetyltransferase of rat brain
Ishida, I., Ichikawa, T., & Deguchi, T. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90273-2 · Cited by 20
Cholinergic synaptic potentials in the supragranular layers of auditory cortex
Bandrowski, A. E., Moore, S. L., & Ashe, J. H. (2001) · Synapse · doi:10.1002/syn.1066 · Cited by 20
Alzheimer patients show a sensitivity decrement over time on a tonic alertness task
Brazzelli, M. G., Cocchini, G., Sala, S. D., et al. (1994) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639408402698 · Cited by 20
A New Tool in the Battle Against Alzheimer's Disease and Aging: Ex Vivo Gene Therapy
Ebert, A. D., & Svendsen, C. N. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.131 · Cited by 19
Alzheimer's disease: an intracellular movement disorder?
Zhu, X., Moreira, P. I., Smith, M. A., & Perry, G. L. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.07.002 · Cited by 19
Scopolamine differentially affects memory of 8- and 16-month-old rats in the double Y-maze
Biggan, S. L., Ingles, J. L., & Beninger, R. J. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00046-1 · Cited by 17
Altered NGF response but not release in the aged septo-hippocampal cholinergic system
WILLIAMS, B., NELSON, M., Granholm, A., Coultrap, S. J., Browning, M. D., & CURTIS, M. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.07.001 · Cited by 16
Effect of a long‐term nerve growth factor treatment on body weight, blood pressure,and serum corticosterone in rats
Taglialatela, G., Foreman, P. J., & Perez-Polo, J. R. (1997) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(97)00032-4 · Cited by 16
Does senile impairment of cholinergic system in rats concern only disturbances in cholinergic phenotype or the progressive degeneration of neuronal cell bodies?
Niewiadomska, G., Wyrzykowska, J., & Chechlacz, M. (2000) · Acta Biochimica Polonica · doi:10.18388/abp.2000_4011 · Cited by 15
Self-citation
Biologic Effects of Nerve Growth Factor on Lesioned Basal Forebrain Neuronsa
Koliatsos, V. E., Clatterbuck, R. E., Gouras, G. K., & Price, D. L. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb00199.x · Cited by 15
Expression of the gene for nerve growth factor (NGF) in the monkey central nervous system
Hayashi, M., Yamashita, A., Shimizu, K., Sogawa, K., & Fujii, Y. (1993) · Brain Research · doi:10.1016/0006-8993(93)90437-r · Cited by 14
Unilateral hippocampal and inferotemporal cortex lesions in opposite hemispheres impair learning of single-pair visual discriminations as well as visuovisual conditional tasks in monkeys
Barefoot, H. C., Maclean, C. J., Baker, H. F., & Ridley, R. M. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00320-0 · Cited by 14
Nerve Growth Factor Differentially Affects Spatial and Recognition Memory in Aged Rats
Niewiadomska, G., Baksalerska-Pazera, M., Gąsiorowska, A., & Mietelska‐Porowska, A. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9209-5 · Cited by 14
Self-citation
Cholinergic medial septum neurons do not degenerate in aged 129/Sv control or p75NGFR−/−mice☆
Ward, N. L., Stanford, L. E., Brown, R. E., & Hagg, T. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00087-7 · Cited by 14
No nerve growth factor response to treatment with memantine in adult rats
Lang, U. E., M�hlbacher, M., Hesselink, M. B., et al. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0090-y · Cited by 13
Do central nervous system neurons require target-derived neurotrophic support for survival throughout adult life and aging?
Svendsen, C., & Mv, S. (1996) · PubMed · Cited by 11
Delayed non-matching to position performance in aged hybrid Fischer 344 × Brown Norway rats: a longitudinal study
Blokland, A., Şık, A., & van der Staay, F. J. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.04.017 · Cited by 10
Conditionally immortal neuroepithelial stem cell grafts restore spatial learning in rats with lesions at the source of cholinergic forebrain projections cholinergic forebrain projections Conditionally immortal neuroepithelial stem cell grafts restore spatial leaming in rats with lesions at the source of cholinergic forebrain projections
Grigoryan, G., Gray, J. A., Rashid, T., et al. (2000) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2000-00158 · Cited by 10
Editorial
Schliebs, R. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00070-7 · Cited by 8
Chapter 20 Trophic regulation of basal forebrain gene expression in aging and Alzheimer's disease
Higgins, G. A., Koh, S., Neve, R. L., Mufson, E. J., Chen, K. S., & Gage, F. H. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)63181-7 · Cited by 5
Nerve growth factor response to excitotoxic lesion of the cholinergic basal forebrain is slightly impaired in aged rats
Gericke, C. A., Lang, U. E., Steckler, T., et al. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0819-z · Cited by 4
Untitled work
(2000) · doi:10.1002/1097-4547(20000915)61:6
Untitled work
(1996) · doi:10.1002/(sici)1098-1063(1996)6:2
Untitled work
(2000) · doi:10.1002/1098-1063(2000)10:6

Flagged first, then by citations

Research works printed but not linked: 3

Etherington, 1987, Comparative effects of nucleus basalis and fimbria–fornix lesions on delayed matching and alteration tests memory, Neurosci Res Commun, 22, 441
Schliebs, 1998, Basal forebrain cholinergic dysfunction-experimental approaches and the diseased brain, Int J Dev Neurosci, 16, 591
Voytko, 1994, Basal forebrain lesions in monkeys disrupt attention but not learning and memory, J Neurosci, 14, 167-16

Sorted by citations

Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress
Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118

See all 67

Authors: Niewiadomska, G., Baksalerska-Pazera, M., & Riedel, G.
Affiliations: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
University of Aberdeen (GB)
ORCID: Riedel, Gernot
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-08
Volume: 33
Issue: 5
Pages: 791-805
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2009.03.039
OpenAlex: W1979648372
Cited by: 67
References: 322
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 9
FWCI: 3.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords: memory impairment, septal lesions, hippocampal ablation, cortical excitability, attention, stimulus detection, dementia, aging, cholinergic markers, functional recovery, learning
MeSH terms: Animals, Cognition Disorders, Hippocampus, Humans, Learning, Nerve Net, Recovery of Function, Septum of Brain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The septo-hippocampal system, learning and recovery of function

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks