Cited by 67Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchCholinesterase and Neurodegenerative Diseases

The DOI matches its Crossref record; 322 of the 322 references it cites were found in a registry or an index.

The septo-hippocampal system, learning and recovery of function

Niewiadomska, Grazyna, Baksalerska-Pazera, Marta, Riedel, Gernot·2009·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2009.03.039

Open this paper in CoChat — free account

Abstract

We understand this review as an attempt to summarize recent advances in the understanding of cholinergic function in cognition. Such a role has been highlighted in the 1970s by the discovery that dementia patients have greatly reduced cholinergic activity in cortex and hippocampus. A brief anatomical description of the major cholinergic pathways focuses on the basal forebrain and its projections to cortex and hippocampus. From this distinction, compelling evidence suggests that the basal forebrain --> cortex projection regulates the excitability of principal cortical neurons and is thereby critically involved in attention, stimulus detection and memory function, although the biological conditions for these functions are still debated. Similar uncertainties remain for the septo-hippocampal cholinergic system. Although initial lesions of the septum caused memory deficits reminiscent of hippocampal ablations, recent and more refined neurotoxic lesion studies which spared non-cholinergic cells of the basal forebrain failed to confirm these memory impairments in experimental animals despite a near total loss of cholinergic labeling. Yet, a decline in cholinergic markers in aging and dementia still stands as the most central piece of evidence for a link between the cholinergic system and cognition and appear to provide valuable targets for therapeutic approaches.

Integrity signals

Registry

Crossref · 10.1016/j.pnpbp.2009.03.039

Cites

322 of 322 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627
Large-scale neurocognitive networks and distributed processing for attention, language, and memory
Mesulam, M. (1990) · Annals of Neurology · doi:10.1002/ana.410280502 · Cited by 2,684
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)
Mesulam, M. M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,329
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
Perry, E., Tomlinson, B. E., Blessed, G., Bergmann, K., Gibson, P., & Perry, R. H. (1978) · British medical journal · doi:10.1136/bmj.2.6150.1457 · Cited by 2,043
Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey
Mesulam, M. ‐., Mufson, E. J., Levey, A. I., & Wainer, B. H. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140206 · Cited by 1,962
Context, time, and memory retrieval in the interference paradigms of Pavlovian learning
Bouton, M. E. (1993) · Psychological Bulletin · doi:10.1037/0033-2909.114.1.80 · Cited by 1,896
Human Memory and the Cholinergic System
Drachman, D. A. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490320001001 · Cited by 1,398
CENTRAL CHOLINERGIC SYSTEMS AND COGNITION
Everitt, B. J., & Robbins, T. W. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.649 · Cited by 1,348
NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES
Bowen, D. M., Smith, C. B., White, P., & DAVISON, A. N. (1976) · Brain · doi:10.1093/brain/99.3.459 · Cited by 1,313
Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284
GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus
Freund, T. F., & Antal, M. (1988) · Nature · doi:10.1038/336170a0 · Cited by 1,283
Attention and executive deficits in Alzheimer's disease: A critical review
Perry, R. J. (1999) · Brain · doi:10.1093/brain/122.3.383 · Cited by 1,252
Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease
Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., et al. (2005) · Science · doi:10.1126/science.1105681 · Cited by 1,214
The cognitive neuroscience of sustained attention: where top-down meets bottom-up.
Sarter, M., Givens, B., & Bruno, J. P. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00044-3 · Cited by 1,194
The Cholinergic Hypothesis of Age and Alzheimer’s Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development
Terry, A. V., & Buccafusco, J. J. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.041616 · Cited by 1,159
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Tuszynski, M. H., Thal, L., Pay, M., Salmon, D. P., U, H. S., Bakay, R., Patel, P., Blesch, A., Vahlsing, H. L., Ho, G., et al. (2005) · Nature Medicine · doi:10.1038/nm1239 · Cited by 1,050
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
Fischer, W., Wictorin, K., Björklund, A., Williams, L., Varon, S. S., & Gage, F. H. (1987) · Nature · doi:10.1038/329065a0 · Cited by 1,024
Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase
Armstrong, D. M., Saper, C. B., Levey, A. I., Wainer, B. H., & Terry, R. D. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902160106 · Cited by 970
The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat
Kimura, H., McGeer, P. L., Peng, J. H., & McGeer, E. G. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902000202 · Cited by 966
Cholinergic systems in mammalian brain and spinal cord
WOOLF, N. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90006-m · Cited by 948
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
Stamer, K., Vogel, R., Thies, E., Mandelkow, E., & Mandelkow, E.-M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200108057 · Cited by 885
Loss of Hippocampal Theta Rhythm Results in Spatial Memory Deficit in the Rat
Winson, J. (1978) · Science · doi:10.1126/science.663646 · Cited by 857
On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis
Bartus, R. T. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7397 · Cited by 829
Neuromodulation: acetylcholine and memory consolidation
Hasselmo, M. E. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01365-0 · Cited by 809
Organization and morphological characteristics of cholonergic neurons: an immunocytochemical study with a monoclonal antibody to choline acetyltransferase
Houser, C. R., Crawford, G. D., Barber, R. P., Salvaterra, P. M., & Vaughn, J. E. (1983) · Brain Research · doi:10.1016/0006-8993(83)91312-4 · Cited by 748
The Cholinergic Synapse and the Site of Memory
Deutsch, J. A. (1972) · Advances in behavioral biology · doi:10.1007/978-1-4684-3060-8_11 · Cited by 740
Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection
Sarter, M., Hasselmo, M. E., Bruno, J. P., & Givens, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.006 · Cited by 667
The Cholinergic Synapse and the Site of Memory
Deutsch, J. A. (1971) · Science · doi:10.1126/science.174.4011.788 · Cited by 662
Memory and cognitive function in man
Drachman, D. A. (1977) · Neurology · doi:10.1212/wnl.27.8.783 · Cited by 619
Cholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: A combined light and electron microscopic study
Frotscher, M., & Léránth, C. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902390210 · Cited by 600
Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues
Selden, N. R. W., Everitt, B. J., Jarrard, L. E., & Robbins, T. W. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90379-3 · Cited by 578
THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON
Perry, E. K. (1986) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072100 · Cited by 565
Mazes, maps, and memory.
Olton, D. S. (1979) · American Psychologist · doi:10.1037//0003-066x.34.7.583 · Cited by 529
Basal forebrain lesions in monkeys disrupt attention but not learning and memory [published erratum appears in J Neurosci 1995 Mar;15(3): following table of contents]
Voytko, M., Olton, D., Richardson, R., Gorman, L. K., Tobin, J., & Price, D. L. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-01-00167.1994 · Cited by 520
Peripheral and Central Mechanisms of NGF‐induced Hyperalgesia
Lewin, G. R., Rueff, A., & Mendell, L. M. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00581.x · Cited by 507
Hippocampal theta activity following selective lesion of the septal cholinergic systeM
Lee, M., Chrobak, J. J., Attila Gabor, S. I. K., Wiley, R. G., & Buzsáki, G. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90341-7 · Cited by 496
Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats
Dunnett, S. B. (1985) · Psychopharmacology · doi:10.1007/bf00432721 · Cited by 487
Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humans
Chudasama, Y., & Robbins, T. W. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.005 · Cited by 484
The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions
Dunnett, S. B., Everitt, B. J., & Robbins, T. W. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90061-x · Cited by 467
An NGF-TrkA-Mediated Retrograde Signal to Transcription Factor CREB in Sympathetic Neurons
Riccio, A., Pierchala, B. A., Ciarallo, C. L., & Ginty, D. D. (1997) · Science · doi:10.1126/science.277.5329.1097 · Cited by 446
Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain
Takahashi, R. H., Almeida, C. G., Kearney, P. F., Yu, F., Lin, M. T., Milner, T. A., & Gouras, G. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5167-03.2004 · Cited by 445
Production of specific antisera and monoclonal antibodies to choline acetyltransferase: characterization and use for identification of cholinergic neurons.
Eckenstein, F. P., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01175.x · Cited by 442
Nerve Growth Factor Gene Expression in the Developing Rat Brain
Large, T. H., Bodary, S. C., Clegg, D., Weskamp, G., Otten, U., & Reichardt, L. F. (1986) · Science · doi:10.1126/science.3764415 · Cited by 435
Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density
McGaughy, J., Kaiser, T., & Sarter, M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.2.247 · Cited by 435 · cited 1×
“Cortical acetylcholine efflux is critical for attention (Chiba et al., 1995; Dalley et al., 2001; Everitt and Robbins, 1997; McGaughy et al., 1996, 2002; Mesulam, 1990; Sarter and Bruno, 1997; 2000; Sarter et al., 1999, 2001; Voytko, 1996) and has an important role to play in signal-driven versus…”
Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor
Wiley, R. G., Oeltmann, T. N., & Lappi, D. A. (1991) · Brain Research · doi:10.1016/0006-8993(91)91199-b · Cited by 417
Cortical cholinergic inputs mediating arousal, attentional processing and dreaming: differential afferent regulation of the basal forebrain by telencephalic and brainstem afferents
Sarter, M. F., & Bruno, J. P. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00487-x · Cited by 417
Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
Mandelkow�, E. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.04.007 · Cited by 412
Medial septal area lesions disrupt theta rhythm and cholinergic staining in medial entorhinal cortex and produce impaired radial arm maze behavior in rats
Mitchell, S., Rawlins, J. N. P., Steward, O., & Olton, D. S. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-03-00292.1982 · Cited by 406
A comparison of the distribution of central cholinergic neurons as demonstrated by acetylcholinesterase pharmacohistochemistry and choline acetyltransferase immunohistochemistry
Satoh, K., Armstrong, D. M., & Fibiger, H. C. (1983) · Brain Research Bulletin · doi:10.1016/0361-9230(83)90013-8 · Cited by 405
The effect of systemically administered recombinant human nerve growth factor in healthy human subjects
Petty, B. G., Cornblath, D. R., Adornato, B. T., Chaudhry, V., Flexner, C. W., Wachsman, M., Sinicropi, D. V., Burton, L. E., & Peroutka, S. J. (1994) · Annals of Neurology · doi:10.1002/ana.410360221 · Cited by 402
Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor
Heckers, S., Ohtake, T., Wiley, R. G., Lappi, D., Geula, C., & Mesulam, M. M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01271.1994 · Cited by 401
Cholinergic systems in the rat brain: I. projections to the limbic telencephalon.
Woolf, N., Eckenstein, F., & Butcher, L. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90236-3 · Cited by 389
Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat1
Flicker, C., DEAN, R., Watkins, D. L., FISHER, S., & Bartus, R. T. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(83)80023-9 · Cited by 370
Behavioural, biochemical and histochemical effects of different neurotoxic amino acids injected into nucleus basalis magnocellularis of rats
Dunnett, S. B., Whishaw, I. Q., Jones, G. H., & Bunch, S. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90117-5 · Cited by 349
Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion
Cooper, J. D., Salehi, A., Delcroix, J.-D., Howe, C. L., Belichenko, P. V., Chua-Couzens, J., Kilbridge, J. F., Carlson, E. J., Epstein, C. J., & Mobley, W. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181219298 · Cited by 336
Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase
Pearson, R. C. A., Sofroniew, M. V., Cuello, A. C., Powell, T. P. S., Eckenstein, F. P., Esiri, M. M., & Wilcock, G. K. (1983) · Brain Research · doi:10.1016/0006-8993(83)90046-x · Cited by 334
Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats.
Baxter, M. G., Bucci, D. J., Gorman, L. K., Wiley, R. G., & Gallagher, M. (2013) · Behavioral Neuroscience · doi:10.1037/a0033939 · Cited by 331
Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system
Torres, E. M., Perry, T., Blokland, A., Wilkinson, L. S., Wiley, R. G., Lappi, D. A., & Dunnett, S. B. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90010-8 · Cited by 329
Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes
Robbins, T. W., Everitt, B. J., Marston, H. M., Wilkinson, J., Jones, G. H., & Page, K. J. (1989) · Behavioural Brain Research · doi:10.1016/s0166-4328(89)80143-3 · Cited by 327
Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis
Berger-Sweeney, J. E., Heckers, S., Mesulam, M. M., Wiley, R. G., Lappi, D., & Sharma, M. C. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-07-04507.1994 · Cited by 327
Conditioned and Unconditioned Stimuli Increase Frontal Cortical and Hippocampal Acetylcholine Release: Effects of Novelty, Habituation, and Fear
Acquas, E., Wilson, C., & Fibiger, H. C. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03089.1996 · Cited by 318
Mitochondrial alterations in Alzheimer's disease
Baloyannis, S. J. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9204 · Cited by 318 · cited 1×
“…et al., 2005; Gotz et al., 2006), residentaxonalproteins suchasneurofilaments and tau, glycogen (Ferrer et al., 2002), and organelles (Ghribi, 2006; Baloyannis, 2006), in addition to the sequestration of tubulin (Hempen and Brion, 1996), a reduced number of microtubules tracks (Cash et al., 2003),…”
Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation
Cash, A., Aliev, G., Siedlak, S. L., Nunomura, A., Fujioka, H., Zhu, X., Raina, A. K., Vinters, H. V., Tabaton, M., Johnson, T., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64296-4 · Cited by 317
Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.
Cras, P. P., Kawai, M., Lowery, D. E., Gonzalez‐DeWhitt, P. A., Greenberg, B., & Perry, G. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7552 · Cited by 314
Selective behavioral and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a five-choice serial reaction time task
McGaughy, J., Dalley, J. W., Morrison, C. H., Everitt, B. J., & Robbins, T. W. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01905.2002 · Cited by 311
Cell Surface Trk Receptors Mediate NGF-Induced Survival While Internalized Receptors Regulate NGF-Induced Differentiation
Zhang, Y.-Z., Moheban, D. B., Conway, B. R., Bhattacharyya, A., & Segal, R. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05671.2000 · Cited by 311
Essential role of neocortical acetylcholine in spatial memory
Winkler, J., Suhr, S. T., Gage, F. H., Thal, L. J., & Fisher, L. J. (1995) · Nature · doi:10.1038/375484a0 · Cited by 310
Postsynaptic targets of GABAergic hippocampal neurons in the medial septum-diagonal band of broca complex
Tóth, K., Borhegyi, Z., & Freund, T. F. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03712.1993 · Cited by 301
Place navigation in rats is impaired by lesions of medial septum and diagonal band but not nucleus basalis magnocellularis
Hagan, J. J., Salamone, J. D., Simpson, J., Iversen, S. D., & Morris, R. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90105-2 · Cited by 293
The Nucleus Basalis Magnocellularis Cholinergic System: One Hundred Years of Progress
Wenk, G. L. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3757 · Cited by 284
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes
Kinoshita, A., Fukumoto, H., Shah, T., Whelan, C. M., Irizarry, M. C., & Hyman, B. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00643 · Cited by 284
Attentional functions of cortical cholinergic inputs: What does it mean for learning and memory?
Sarter, M. F., Bruno, J. P., & Givens, B. S. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00070-4 · Cited by 283
Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration
Tuszynski, M. H., U, H., Amaral, D., & Gage, F. H. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-11-03604.1990 · Cited by 281
Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice
Capsoni, S., Ugolini, G., Comparini, A., Ruberti, F., Berardi, N., & Cattaneo, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6826 · Cited by 279
Distinct Changes in Cortical Acetylcholine and Noradrenaline Efflux during Contingent and Noncontingent Performance of a Visual Attentional Task
Dalley, J. W., McGaughy, J., O'Connell, M. T., Cardinal, R. N., Levita, L., & Robbins, T. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04908.2001 · Cited by 277
VISUOSPATIAL ATTENTION IN DEMENTIA OF THE ALZHEIMER TYPE
Parasuraman, R., Greenwood, P. M., Haxby, J. V., & Grady, C. L. (1992) · Brain · doi:10.1093/brain/115.3.711 · Cited by 274
Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex
Watson, F. L., Heerssen, H. M., Moheban, D. B., Lin, M. Z., Sauvageot, C. M., Bhattacharyya, A., Pomeroy, S. L., & Segal, R. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07889.1999 · Cited by 272
Topography of choline acetyltransferase-containing neurons in the forebrain of the rat
Sofroniew, M. V., Eckenstein, F. P., Thoenen, H., & Cuello, A. C. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90121-5 · Cited by 269
The role of acetylcholine in cortical synaptic plasticity
Rasmusson, D. D. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00259-x · Cited by 267
NGF improves spatial memory in aged rodents as a function of age
Fischer, W., Björklund, A., Chen, K., & Gage, F. H. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-07-01889.1991 · Cited by 260
Basal forebrain cholinergic lesions disrupt increments but not decrements in conditioned stimulus processing
Chiba, A., Bucci, D., Holland, P., & Gallagher, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07315.1995 · Cited by 257
Attention and the frontal cortex as examined by simultaneous temporal processing
Olton, D. S., Wenk, G. L., Church, R. M., & Meck, W. H. (1988) · Neuropsychologia · doi:10.1016/0028-3932(88)90083-8 · Cited by 257
Conditioning and contextual retrieval in hippocampal rats.
Good, M. A., & Honey, R. C. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.4.499 · Cited by 256
Behavioral, biochemical, histological, and electrophysiological effects of 192 IgG-saporin injections into the basal forebrain of rats
Wenk, G. L., Stoehr, J. D., Quintana, G., Mobley, S., & Wiley, R. G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-05986.1994 · Cited by 252
Multiple output pathways of the basal forebrain: organization, chemical heterogeneity, and roles in vigilance
Semba, K. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00254-0 · Cited by 250
Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats.
Baxter, M. G., Bucci, D. J., Gorman, L. K., Wiley, R. G., & Gallagher, M. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.714 · Cited by 248
Selective memory loss following nucleus basalis lesions: Long term behavioral recovery despite persistent cholinergic deficiencies
Bartus, R. T., Flicker, C., Dean, R. L., Pontecorvo, M. J., Figueiredo, J. C., & Fisher, S. K. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90139-x · Cited by 246
Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis
Lyness, S. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00057-x · Cited by 240
Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation
Woolf, C. J., Ma, Q., Allchorne, A. J., & Poole, S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02716.1996 · Cited by 236
Innervation of different peptide-containing neurons in the hippocampus by gabaergic septal afferents
Gulyás, A. I., Görcs, T. J., & Freund, T. F. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90189-b · Cited by 234
The septo-hippocampal system and cognitive mapping
Rawlins, J. N. P., & Olton, D. S. (1982) · Behavioural Brain Research · doi:10.1016/0166-4328(82)90039-0 · Cited by 226
The Role of Nerve Growth Factor Receptors in Cholinergic Basal Forebrain Degeneration in Prodromal Alzheimer Disease
Counts, S., & Mufson, E. J. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.4.263 · Cited by 223
Cholinergic-rich brain transplants reverse alcohol-induced memory deficits
Arendt, T., Allen, Y. S., Sinden, J. D., Schugens, M. M., Marchbanks, R. M., Lantos, P. L., & Gray, J. A. (1988) · Nature · doi:10.1038/332448a0 · Cited by 214
The role of cholinergic projections from the nucleus basalis in memory
Dekker, A. D. J. A. M., Connor, D. J., & Thal, L. J. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80008-9 · Cited by 211
Choline acetyltransferase immunohistochemistry in brains of alzheimer's disease patients and controls
Nagai, T., McGeer, P. L., Peng, J., et al. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90264-1 · Cited by 209
Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired
Quirion, R., Wilson, A. L., Rowe, W. B., Aubert, I., Richard, J., Doods, H. N., Parent, A., White, N. M., & Meaney, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-02-01455.1995 · Cited by 205
Dissociable effects on spatial maze and passive avoidance acquisition and retention following AMPA- and ibotenic acid-induced excitotoxic lesions of the basal forebrain in rats: Differential dependence on cholinergic neuronal loss
Page, K. J., Everitt, B. J., Robbins, T. W., Marston, H. M., & Wilkinson, L. S. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90308-b · Cited by 204
Comparative distribution of nicotinic receptor subtypes during development, adulthood and aging: an autoradiographic study in the rat brain
Tribollet, E., Bertrand, D., Marguerat, A., & Raggenbass, M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.028 · Cited by 199
Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
Ferrer, I., Barrachina, M., & Puig, B. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0587-8 · Cited by 197
A Potential Noninvasive Neurobiological Test for Alzheimer's Disease
Scinto, L. F. M., Daffner, K. R., Dressler, D., Ransil, B. I., Rentz, D. M., Weıntraub, S., Mesulam, M. M., & Potter, H. (1994) · Science · doi:10.1126/science.7973660 · Cited by 197
Septohippocampal Acetylcholine: Involved in but not Necessary for Learning and Memory?Preprint
Parent, M. B., & Baxter, M. G. (2004) · Learning & Memory · doi:10.1101/lm.69104 · Cited by 194
Cognitive sequelae of head injury: involvement of basal forebrain and associated structures
Salmond, C. H. (2004) · Brain · doi:10.1093/brain/awh352 · Cited by 194
Association of Trk Neurotrophin Receptors with Components of the Cytoplasmic Dynein Motor
Yano, H., Lee, F. S., Kong, H., Chuang, J.-Z., Arévalo, J. C., Pérez, P., Sung, C.-H., & Chao, M. V. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-j0003.2001 · Cited by 193
Aged Rats Are Impaired on an Attentional Set-Shifting Task Sensitive to Medial Frontal Cortex Damage in Young RatsPreprint
Barense, M. D., Fox, M. T., & Baxter, M. G. (2002) · Learning & Memory · doi:10.1101/lm.48602 · Cited by 191
Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG–saporin-induced lesions of the medial prefrontal cortex
Dalley, J. W. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh052 · Cited by 191
A comparative analysis of the role of fornix and cingulate cortex in memory: rats
Markowska, A. L., Olton, D. S., Murray, E. A., & Gaffan, D. (1989) · Experimental Brain Research · doi:10.1007/bf00248292 · Cited by 189
Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model
Molchan, S. E., Martinez, R. A., Hill, J. L., Weingartner, H. J., Thompson, K., Vitiello, B., & Sunderland, T. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90017-g · Cited by 187
Chemical anatomy of primate basal ganglia
Parent, A., Côté, P., & Lavoie, B. A. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)80010-6 · Cited by 186
Repeated Cocaine Modifies the Mechanism by which Amphetamine Releases Dopamine
Pierce, R. C., & Kalivas, P. W. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03254.1997 · Cited by 179
Prenatal exposure to moderate levels of ethanol can have long-lasting effects on hippocampal synaptic plasticity in adult offspring
Sutherland, R. J., McDonald, R. J., & Savage, D. D. (1997) · Hippocampus · doi:10.1002/(sici)1098-1063(1997)7:2 · Cited by 178
Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease.
Hempen, B., & Brion, J. (1996) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199609000-00003 · Cited by 177
Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3
Katoh‐Semba, R., Semba, R., TAKEUCHI, I. K., & Kato, K. (1998) · Neuroscience Research · doi:10.1016/s0168-0102(98)00040-6 · Cited by 172
192 immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells
Waite, J. J., Chen, A. D., Wardlow, M. L., et al. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00479-o · Cited by 171
Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey
Koliatsos, V., Nauta, H. J. W., Clatterbuck, R. E., Holtzman, D. M., Mobley, W. C., & Price, D. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-12-03801.1990 · Cited by 170
Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor.
Fischer, W., Sirevaag, A. M., Wiegand, S. J., Lindsay, R. M., & Björklund, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8607 · Cited by 170
Alzheimer Disease, Attention, and the Cholinergic System
Lawrence, A. D., & Sahakian, B. J. (1995) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199501002-00008 · Cited by 169
Basal Forebrain Cholinergic Dysfunction in Alzheimer’s Disease – Interrelationship with β-amyloid, Inflammation and Neurotrophin Signaling
Schliebs, R. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6962-9 · Cited by 167
Cognitive functions of the basal forebrain cholinergic system in monkeys: memory or attention?
Voytko, M. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00143-3 · Cited by 167
Neuron atrophy during aging: programmed or sporadic?
Finch, C. E. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90134-8 · Cited by 166
Differential modulation of auditory thalamocortical and intracortical synaptic transmission by cholinergic agonist
Hsieh, C. Y., Cruikshank, S. J., & Metherate, R. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02766-9 · Cited by 165
The nucleus basalis and memory codes: Auditory cortical plasticity and the induction of specific, associative behavioral memory
Weinberger, N. M. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00072-8 · Cited by 165
Cholinergic modulation of responses to single tones produces tone‐specific receptive field alterations in cat auditory cortex
Metherate, R., & Weinberger, N. M. (1990) · Synapse · doi:10.1002/syn.890060204 · Cited by 164
Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration.
Tuszynski, M. H., Roberts, J. A., Senut, M., U, H. S., & Gage, F. H. (1996) · PubMed · Cited by 164
Projections to the rostral reticular thalamic nucleus in the rat
Cornwall, J., Cooper, J. D., & Phillipson, O. T. (1990) · Experimental Brain Research · doi:10.1007/bf00228857 · Cited by 163
Comparative effects of quisqualic and ibotenic acid-induced lesions of the substantia innominata and globus pallidus on the acquisition of a conditional visual discrimination: Differential effects on cholinergic mechanisms
Robbins, T. W., Everitt, B. J., Ryan, C. N., Marston, H. M., Jones, G. H., & Page, K. J. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90181-4 · Cited by 161
Removal of the hippocampus and transection of the fornix produce comparable deficits on delayed non-matching to position by rats
Aggleton, J. P., Keith, A. B., Rawlins, J. N. P., Hunt, P. R., & Sahgal, A. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80325-0 · Cited by 161
Abnormal regulation of corticopetal cholinergic neurons and impaired information processing in neuropsychiatric disorders
Sarter, M. F., & Bruno, J. P. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01289-2 · Cited by 161
Modulation of hippocampal synaptic transmission and plasticity by neurotrophins
Lu, B., & Gottschalk, W. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)28020-5 · Cited by 159
Cholinergic innervation of the monkey amygdala: An immunohistochemical analysis with antisera to choline acetyltransferase
Amaral, D. G., & Bassett, J. L. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902810303 · Cited by 156
Convergent cholinergic activities in aging and Alzheimer's disease
Perry, E. K., Johnson, M. H., Kerwin, J. M., Piggott, M. A., COURT, J. A., Shaw, P. J., Ince, P. G., Brown, A. J., & Perry, R. H. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90113-c · Cited by 155
Neural Systems Underlying Arousal and Attention: Implications for Drug Abusea
Robbins, T. W., Granon, S., Muir, J. L., Durantou, F., Harrison, A. A., & Everitt, B. J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09740.x · Cited by 152
Injection of IgG 192-saporin into the medial septum produces cholinergic hypofunction and dose-dependent working memory deficits
Walsh, T. J., Herzog, C. D., Gandhi, C. C., Stackman, R. W., & Wiley, R. G. (1996) · Brain Research · doi:10.1016/0006-8993(96)00271-5 · Cited by 151
Developmental origins of the age-related decline in cortical cholinergic function and associated cognitive abilities
Sarter, M. F., & Bruno, J. P. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.011 · Cited by 150
Chapter 49: Role of forebrain cholinergic systems in learning and memory: relevance to the cognitive deficits of aging and Alzheimer's dementia
Dunnett, S. B., & Fibiger, H. C. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)62425-5 · Cited by 147
From arousal to cognition: the integrative position of the prefrontal cortex
Robbins, T. W. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)26030-5 · Cited by 147
Cholinergic Modulation of Visual Attention and Working Memory: Dissociable Effects of Basal Forebrain 192-IgG-saporin Lesions and Intraprefrontal Infusions of ScopolaminePreprint
Chudasama, Y., Dalley, J. W., Nathwani, F., Bouger, P., & Robbins, T. W. (2004) · Learning & Memory · doi:10.1101/lm.70904 · Cited by 146
Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: Correlation with Alzheimer's neuropathology
Ikonomovic, M., Mufson, E., Wuu, J., Cochran, E., Bennett, D., & DeKosky, S. (2003) · Journal of Alzheimer's Disease · doi:10.3233/jad-2003-5106 · Cited by 145
Cholinergic modulation of hippocampal cells and circuits
Cobb, S., & Davies, C. H. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.076539 · Cited by 145
Hypophagia is induced by intracerebroventricular administration of nerve growth factor
Williams, L. R. (1991) · Experimental Neurology · doi:10.1016/0014-4886(91)90143-z · Cited by 141
Brain cholinergic vulnerability: Relevance to behavior and disease
McKinney, M. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.05.019 · Cited by 140
Learning impairments following injection of a selective cholinergic immunotoxin, ME20.4 IgG-saporin, into the basal nucleus of Meynert in monkeys
Fine, A., Hoyle, C., Maclean, C. J., LeVatte, T. L., Baker, H. F., & Ridley, R. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00208-x · Cited by 138
Characterization of an NGF–P-TrkA Retrograde-Signaling Complex and Age-Dependent Regulation of TrkA Phosphorylation in Sympathetic Neurons
Pierchala, B. A., & Ginty, D. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08207.1999 · Cited by 138
Enhanced acetylcholine release in hippocampus and cortex during the anticipation and consumption of a palatable meal
Inglis, F. M., Day, J. C., & Fibiger, H. C. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90342-5 · Cited by 136
Nerve growth factor levels and choline acetyltransferase activity in the brain of aged rats with spatial memory impairments
Hellweg, R., Fischer, W., Hock, C., Gage, F. H., Björklund, A., & Thoenen, H. (1990) · Brain Research · doi:10.1016/0006-8993(90)90348-f · Cited by 135
Traffic at the intersection of neurotrophic factor signaling and neurodegeneration
Salehi, A., Delcroix, J.-D., & Mobley, W. C. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00038-3 · Cited by 131
Neuron number in the parahippocampal region is preserved in aged rats with spatial learning deficits.
Rapp, P., Deroche, P. S., Mao, Y., & Burwell, R. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.11.1171 · Cited by 131
Chapter 28 The modular organization of brain systems. Basal forebrain: the last frontier
Záborszky, L. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36030-8 · Cited by 129
Correlations of hippocampal atrophy and focal low-frequency magnetic activity in Alzheimer disease: volumetric MR imaging-magnetoencephalographic study.
Fernández, A., Arrazola, J., Maestú, F., Amo, C., Gil‐Gregorio, P., Wienbruch, C., & Ortiz, T. (2003) · PubMed Central · Cited by 128
Enhanced acetylcholine release in the hippocampus and cortex during acquisition of an operant behavior
Orsetti, M., Casamenti, F., & Pepeu, G. (1996) · Brain Research · doi:10.1016/0006-8993(96)00292-2 · Cited by 126
The thalamo-cortical auditory receptive fields: regulation by the states of vigilance, learning and the neuromodulatory systems
Edeline, J. (2003) · Experimental Brain Research · doi:10.1007/s00221-003-1608-0 · Cited by 122
Intact spatial learning following lesions of basal forebrain cholinergic neurons
Baxter, M. G., Bucci, D. J., Sobel, T. J., Williams, M. J., Gorman, L. K., & Gallagher, M. (1996) · Neuroreport · doi:10.1097/00001756-199605310-00019 · Cited by 119
Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?
Götz, J., Ittner, L. M., & Kins, S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03955.x · Cited by 119
Retrograde Transport and Steady-State Distribution of125I-Nerve Growth Factor in Rat Sympathetic Neurons in Compartmented Cultures
Ure, D., & Campenot, R. B. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-04-01282.1997 · Cited by 119
Loss of NGF receptor immunoreactivity in basal forebrain neurons of aged rats: correlation with spatial memory impairment
Koh, S., Chang, P., Collier, T. J., & Loy, R. (1989) · Brain Research · doi:10.1016/0006-8993(89)91125-6 · Cited by 118
Role of neurotrophins in cholinergic-neurone function in the adult and aged CNS
Rylett, R. J., & Williams, L. R. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90138-4 · Cited by 118
The Aging Hippocampus: Navigating Between Rat and Human Experiments
Driscoll, I. F., & Sutherland, R. J. (2005) · Reviews in the Neurosciences · doi:10.1515/revneuro.2005.16.2.87 · Cited by 117
Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients
Kordower, J. H., Gash, D. M., Bothwell, M. A., Hersh, L. B., & Mufson, E. J. (1989) · Neurobiology of Aging · doi:10.1016/s0197-4580(89)80013-2 · Cited by 117
Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated trka expression in the medial septum of aged rats
Cooper, J. D., Lindholm, D., & Sofroniew, M. V. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90462-6 · Cited by 116
Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory.
Shen, J., Barnes, C. A., Wenk, G. L., & McNaughton, B. L. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.5.1181 · Cited by 116
Nontropic actions of neurotrophins: Subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation
Conner, J. M., Darracq, M. A., Roberts, J., & Tuszynski, M. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1941 · Cited by 116
Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain.
Martı́nez-Serrano, A., Fischer, W., Söderström, S., Ebendal, T., & Björklund, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6355 · Cited by 116
Aging is associated with a diffuse impairment of forebrain cholinergic neurons
Altavista, M. C., Rossi, P., Bentivoglio, A. R., Crociani, P., & Albanese, A. (1990) · Brain Research · doi:10.1016/0006-8993(90)91116-x · Cited by 112
Reevaluation of the contribution of the basal forebrain cholinergic system to memory
Kesner, R. P. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80122-2 · Cited by 111
Regional variations in cortical cholinergic innervation: Chemoarchitectonics of acetylcholinesterase-containing fibers in the macaque brain
Mesulam, M. M., Rosen, A. D., & Mufson, E. J. (1984) · Brain Research · doi:10.1016/0006-8993(84)90087-8 · Cited by 110
Basal Forebrain Afferent Projections Modulating Cortical Acetylcholine, Attention, and Implications for Neuropsychiatric Disorders
Sarter, M. F., Bruno, J. P., & Turchi, J. N. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09277.x · Cited by 110
Cognitive Aging and the Hippocampus: How Old Rats Represent New Environments
Wilson, I. A., Ikonen, S., Gureviciene, I., McMahan, R. W., Gallagher, M., Eichenbaum, H., & Tanila, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5205-03.2004 · Cited by 107
Distribution of septohippocampal neurons containing parvalbumin or choline acetyltransferase in the rat brain
Kiss, J. Z., Patel, A. J., & Freund, T. F. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902980308 · Cited by 106
Cholinergic neurons in the hippocampus
Frotscher, M., Schlander, M., & L�r�nth, C. (1986) · Cell and Tissue Research · doi:10.1007/bf00215891 · Cited by 106
The Cognitive Psychopharmacology of Alzheimer's Disease: Focus on Cholinergic Systems
Lawrence, A. D., & Sahakian, B. J. (1998) · Neurochemical Research · doi:10.1023/a:1022419712453 · Cited by 105
Selective Immunolesioning of the Basal Forebrain Cholinergic System Disrupts Short‐term Memory in Rats
Leanza, G., Muir, J. L., Nilsson, O., Wiley, R. G., Dunnett, S. B., & Björklund, A. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01616.x · Cited by 104
Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7‐deficient mice
Fragkouli, A., Hearn, C. J., Errington, M. L., Cooke, S. F., Grigoriou, M. E., Bliss, T., Stylianopoulou, F., & Pachnis, V. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04141.x · Cited by 103
Behavioral Pharmacology and Biochemistry of Central Cholinergic Neurotransmission
Fibiger, H. C., Damsma, G., & Day, J. C. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0145-6_23 · Cited by 102
Acetylcholine synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats
Rylett, R. J., Goddard, S., Schmidt, B., & Williams, L. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03956.1993 · Cited by 101
High‐resolution imaging demonstrates dynein‐based vesicular transport of activated trk receptors
Bhattacharyya, A., Watson, F. L., Pomeroy, S. L., Zhang, Y. Z., Stiles, C. D., & Segal, R. A. (2002) · Journal of Neurobiology · doi:10.1002/neu.10062 · Cited by 100
Age‐related shrinkage of cortically projecting cholinergic neurons: A selective effect
Mesulam, M., Mufson, E. J., & Rogers, J. (1987) · Annals of Neurology · doi:10.1002/ana.410220109 · Cited by 100
Calretinin is present in non-pyramidal cells of the rat hippocampus—III. Their inputs from the median raphe and medial septal nuclei
Acsády, L., Halasy, K., & Freund, T. F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90532-k · Cited by 99
Cholinergic system regulation of spatial representation by the hippocampus
Ikonen, S., McMahan, R., Gallagher, M., Eichenbaum, H., & Tanila, H. (2002) · Hippocampus · doi:10.1002/hipo.1109 · Cited by 96
Cholinergic cell loss and hypertrophy in the medial septal nucleus of the behaviorally characterized aged rhesus monkey
Stroessner-Johnson, H., Rapp, P. R., & Amaral, D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-01936.1992 · Cited by 95
Cholinergic and gabaergic neurons in the nucleus basalis region of young and aged rats
Smith, M. L., & Booze, R. M. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00076-u · Cited by 95
Differential changes in cell size and number in topographic subdivisions of human basal nucleus in normal aging
Lacalle, S. D., Iráizoz, I., & Gonzalo, L. M. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90307-a · Cited by 95
Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm
Johnson, D. A., Zambon, N. J., & Gibbs, R. B. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02623-9 · Cited by 95
Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory.
Shen, J., Barnes, C. A., Wenk, G. L., et al. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.5.1181 · Cited by 95
Septal GABAergic neurons innervate inhibitory interneurons in the hippocampus of the macaque monkey
Gulyás, A. I., Seress, L., Tóth, K., Acsády, L., Antal, M., & Freund, T. F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90334-k · Cited by 93
Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats
Henriksson, B. G., Söderström, S., Gower, A. J., Ebendal, T., Winblad, B. G., & Mohammed, A. H. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80134-2 · Cited by 91
Nucleus basalis involvement in conditioned neuronal responses in the rat frontal cortex
Rigdon, G., & Jh, P. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-09-02535.1986 · Cited by 90
Impaired and spared cholinergic functions in the hippocampus after lesions of the medial septum/vertical limb of the diagonal band with 192 IgG‐saporin
Chang, Q., & Gold, P. E. (2004) · Hippocampus · doi:10.1002/hipo.10160 · Cited by 89
GABAergic septohippocampal neurons are not necessary for spatial memory
Pang, K. C. H., Nocera, R., Secor, A. J., & Yoder, R. M. (2001) · Hippocampus · doi:10.1002/hipo.1097 · Cited by 88
Molecular mechanisms regulating the retrograde axonal transport of neurotrophins
Reynolds, A. J., Bartlett, S. E., & Hendry, I. A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00028-x · Cited by 85
Role of cholinergic system on the construction of memories: Taste memory encoding
Miranda, M. I. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00061-3 · Cited by 85
NGF gene transfer to intrinsic basal forebrain neurons increases cholinergic cell size and protects from age-related, spatial memory deficits in middle-aged rats
Klein, R. L., Hirko, A. C., Meyers, C., Grimes, J. R., Muzyczka, N., & Meyer, E. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02634-2 · Cited by 84
Nerve growth factor mRNA‐containing cells are distributed within regions of cholinergic neurons in the rat basal forebrain
Lauterborn, J. C., Isackson, P. J., & Gall, C. M. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903060308 · Cited by 84
Differential correlation between neurochemical deficits, neuropathology, and cognitive status in Alzheimer's disease
Dournaud, P., Delaère, P., Hauw, J., & Epelbaum, J. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00086-t · Cited by 83
Differential changes in cholinergic markers from selected brain regions after specific immunolesion of the rat cholinergic basal forebrain system
Roßner, S., Schliebs, R., Perez-Polo, J. R., et al. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490400105 · Cited by 82
Nerve growth factor in treatment and pathogenesis of Alzheimer's disease
Williams, B. J., Eriksdotter, M., & Granholm, A. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.09.001 · Cited by 81
Impairment in memory function and neurodegenerative changes in the cholinergic basal forebrain system induced by chronic intake of ethanol
Arendt, T. (1994) · Springer eBooks · doi:10.1007/978-3-7091-9350-1_13 · Cited by 79
Nerve growth factor increases extracellular acetylcholine levels in the parietal cortex and hippocampus of aged rats and restores object recognition
Scali, C., Casamenti, F., Pazzagli, M., Bartolini, L., & Pepeu, G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90253-4 · Cited by 78
Synaptic interactions involving acetylcholine, glutamate, and GABA in rat auditory cortex
Metherate, R., & Ashe, J. H. (1995) · Experimental Brain Research · doi:10.1007/bf00228017 · Cited by 78

Research works printed but not linked: 3

Etherington, 1987, Comparative effects of nucleus basalis and fimbria–fornix lesions on delayed matching and alteration tests memory, Neurosci Res Commun, 22, 441
Schliebs, 1998, Basal forebrain cholinergic dysfunction-experimental approaches and the diseased brain, Int J Dev Neurosci, 16, 591
Voytko, 1994, Basal forebrain lesions in monkeys disrupt attention but not learning and memory, J Neurosci, 14, 167-16

Sorted by citations

Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress
Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118

See all 67

Authors: Niewiadomska, G., Baksalerska-Pazera, M., & Riedel, G.
Affiliations: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
University of Aberdeen (GB)
ORCID: Riedel, Gernot
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-08
Volume: 33
Issue: 5
Pages: 791-805
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2009.03.039
OpenAlex: W1979648372
Cited by: 67
References: 322
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 9
FWCI: 3.06
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords: memory impairment, septal lesions, hippocampal ablation, cortical excitability, attention, stimulus detection, dementia, aging, cholinergic markers, functional recovery, learning
MeSH terms: Animals, Cognition Disorders, Hippocampus, Humans, Learning, Nerve Net, Recovery of Function, Septum of Brain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The septo-hippocampal system, learning and recovery of function

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks