Cited by 105Obsessive-Compulsive Spectrum DisordersPsychoanalysis and Psychopathology ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Genetics of obsessive-compulsive disorder

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Nestadt, Gerald, Grados, Marco, Samuels, Jack F.·2010·Psychiatric Clinics of North America

Abstract

Obsessive-compulsive disorder is a common debilitating condition affecting individuals from childhood through adult life. There is good evidence of genetic contribution to its etiology, but environmental risk factors also are likely to be involved. The condition probably has a complex pattern of inheritance. Molecular studies have identified several potentially relevant genes, but much additional research is needed to establish definitive causes of the condition.

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Crossref · 10.1016/j.psc.2009.11.001

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  1. [6]Murray CL Lopez AD The Global Burden of Disease 1996 Harvard University Press Cambridge
  2. [36]Hanna G Abstract. Biological Psychiatry Conference May 2000 2004
  3. [81]Schindler KM Richter MA Kennedy JL Association between homozygosity at the COMT gene locus and obsessive compulsive disorder Am.J.Med.Genet 2000 96 721 724 11121168

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Authors
Nestadt, G., Grados, M., & Samuels, J. F.
Affiliations
Johns Hopkins University (US)
Corresponding author
Nestadt, Gerald
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
2010-03
Volume
33
Issue
1
Pages
141-158
ISSN
0193-953X (ISSN-L)
OpenAlex
W2129988353
Cited by
105
References
149
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 11 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 5 · 2016: 4 · 2015: 12 · 2014: 10 · 2013: 7 · 2012: 3
FWCI
0.84
Type
journal article
Language
en
Open access
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH050214, R01MH071507, R01 MH 50214)
  • National Center for Research Resources (RR 000 52)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
obsessive-compulsive disorder, genetics, genetic etiology, multifactorial inheritance, environmental risk factors, candidate genes, molecular genetics
MeSH terms
Environment, Humans, Genetic Linkage, Obsessive-Compulsive Disorder, Phenotype, Genetic Association Studies

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