Psychosocial Interventions for Late-life Major Depression: Evidence-Based Treatments, Predictors of Treatment Outcomes, and Moderators of Treatment Effects
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This systematic review evaluates the efficacy of psychosocial interventions for the acute treatment of late-life depression and identifies predictors of treatment outcomes and moderators of treatment effects. Problem-solving therapy, cognitive behavioral therapy, and treatment initiation and participation program have supportive evidence of efficacy, pending replication. Although the data on predictors of treatment outcomes and moderators of treatment effects are preliminary, it appears that baseline anxiety and stress level, personality disorders, endogenous depression, and reduced self-rated health predict worse depression outcomes. Future research may examine the moderating effects of baseline depression severity and identify other clinical or demographic moderators.
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Problem solving therapy, cognitive behavioral therapy, and interpersonal therapy are effective in the treatment of LLD.
“Problem solving therapy, cognitive behavioral therapy, and interpersonal therapy are effective in the treatment of LLD160.”
From Mechanisms and treatment of late-life depression (2019) · cites this paper as [160]
In previous reviews cognitive behavioral therapy was more efficacious than passive control interventions.
“In previous reviews cognitive behavioral therapy was more efficacious than passive control interventions ( Kiosses et al., 2011;Peng et al., 2009;Wilson et al., 2008 )”
From Efficacy and tolerability of pharmacological and non-pharmacological interventions in older patients with major depressive disorder: A systematic review, pairwise and network meta-analysis (2019) · cites this paper as Kiosses et al., 2011
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- Authors
- Kiosses, D. N., Leon, A. C., & Areán, P. A.
- Affiliations
- Cornell University (US)
- Weill Cornell Medicine (US)
- University of California, San Francisco (US)
- Corresponding author
- Kiosses, Dimitris N.
- Venue
- Psychiatric Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 34
- Issue
- 2
- Pages
- 377-401
- ISSN
- 0193-953X (ISSN-L)
- PMC
- PMC3099466
- OpenAlex
- W1968743793
- Cited by
- 91
- References
- 123
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 9 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 13 · 2013: 12 · 2012: 4
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatric Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH091045, K23MH074659)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- geriatric depression, psychosocial interventions, problem-solving therapy, cognitive behavioral therapy, predictors of treatment outcome, treatment moderators, baseline anxiety, stress, personality disorders, endogenous depression, self-rated health, older adults
- MeSH terms
- Aged, Aging, Cognition, Major Depressive Disorder, Humans, Problem Solving, Psychotherapy, Social Support, Cognitive Behavioral Therapy, Treatment Outcome, Evidence-Based Medicine
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