Heart rate variability during motor and cognitive tasks in females with major depressive disorder
Open accessAbstract
Research indicates that major depressive disorder (MDD) is associated with alterations in autonomic control, particularly cardiac control as measured by heart rate variability (HRV). In this preliminary study, we investigated the neural correlates of autonomic control by measuring both HRV and associated brain activity during the performance of mildly stressful tasks. Medically healthy female subjects with MDD (N=10) and healthy controls (N=7) underwent H(2)(15)O-positron emission tomography (PET) and electrocardiographic ECG recording while performing a handgrip motor task and an n-back task. Indices of HRV were calculated and correlated with regional cerebral blood flow (rCBF). Differences in the rCBF and HRV correlations between depressed and healthy subjects were evident in both the medial and lateral orbital cortices. In addition, these areas appeared to be involved in different facets of autonomic control with regard to sympathetic or parasympathetic dominance of cardiac control. These results are consistent with the known roles of networks within the orbital cortex in both autonomic control and the pathophysiology of MDD.
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Depressed adults exhibit blunted RSA withdrawal to physical challenges, such as a handgrip task.
“as well as physical challenges, such as a handgrip task (Nugent et al., 2011).”
From Physiological feelings (2019) · cites this paper as Nugent et al., 2011
The Discussion reports greater lnHF during handgrip in females with major depressive disorder than in controls and interprets it as attenuated parasympathetic withdrawal. The Methods (2.4) identify HF heart-rate variability as a vagally mediated measure, but the study measured lnHF rather than RSA directly and studied only females, so it does not establish the claim for depressed adults generally. (LLM, conf=0.84)
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- Authors
- Nugent, A. C., Bain, E. E., Thayer, J. F., Sollers, J. J., & Drevets, W. C.
- Affiliations
- National Institutes of Health (US)
- Abbott (United States) (US)
- The Ohio State University (US)
- University of Auckland (NZ)
- Laureate Institute for Brain Research (US)
- Corresponding author
- Nugent, Allison Carol
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 191
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3032348
- OpenAlex
- W1992529243
- Cited by
- 54
- References
- 67
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 MH999999)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, heart rate variability, autonomic regulation, cardiac regulation, regional cerebral blood flow, orbital cortex, medial orbitofrontal cortex, lateral orbitofrontal cortex, n-back task, female patients, stress response
- MeSH terms
- Adult, Analysis of Variance, Brain, Brain Mapping, Cerebrovascular Circulation, Cognition, Depressive Disorder, Electrocardiography, Female, Heart Rate, Humans, Neuropsychological Tests, Statistics as Topic, Hand Strength, Positron-Emission Tomography, Young Adult
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