Cognition-related brain networks underpin the symptoms of unipolar depression: Evidence from a systematic review
Abstract
This systematic review sources the latest neuroimaging evidence for the role of cognition-related brain networks in depression, and relates their abnormal functioning to symptoms of the disorder. Using theoretically informed and rigorous inclusion criteria, we integrate findings from 59 functional neuroimaging studies of adults with unipolar depression using a narrative approach. Results demonstrate that two distinct neurocognitive networks, the autobiographic memory network (AMN) and the cognitive control network (CCN), are central to the symptomatology of depression. Specifically, hyperactivity of the introspective AMN is linked to pathological brooding, self-blame, rumination. Anticorrelated under-engagement of the CCN is associated with indecisiveness, negative automatic thoughts, poor concentration, distorted cognitive processing. Downstream effects of this imbalance include reduced regulation of networks linked to the vegetative and affective symptoms of depression. The configurations of these networks can change between individuals and over time, plausibly accounting for both the variable presentation of depressive disorders and their fluctuating course. Framing depression as a disorder of neurocognitive networks directly links neurobiology to psychiatric practice, aiding researchers and clinicians alike.
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Support for the triple network model has been rapidly mounting within the internalizing-disorder domain.
“Since its inception, support for this model has been rapidly mounting within the ID-domain (e.g. [56–59]).”
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Chronic activation of a negative engram induces behavioral and cellular abnormalitiesPreprint
Jellinger, A. L., Suthard, R. L., Yuan, B., Surets, M., Ruesch, E. A., Caban, A. J., Liu, X. S., Shpokayte, M., & Ramirez, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.15.567268
Chronic activation of a negative engram induces behavioral and cellular abnormalitiesPreprint
Jellinger, A. L., Suthard, R. L., Yuan, B., Surets, M., Ruesch, E. A., Caban, A. J., Liu, X. S., Shpokayte, M., & Ramirez, S. (2024) · eLife · doi:10.7554/elife.96281.1
Mood Disorders in the Twenty-First Century
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Chronic activation of a negative engram induces behavioral and cellular abnormalitiesPreprint
Jellinger, A. L., Suthard, R. L., Yuan, B., Surets, M., Ruesch, E. A., Caban, A. J., Liu, X. S., Shpokayte, M., & Ramirez, S. (2024) · eLife · doi:10.7554/elife.96281.2
Chronic activation of a negative engram induces behavioral and cellular abnormalities
Jellinger, A. L., Suthard, R. L., Yuan, B., Surets, M., Ruesch, E. A., Caban, A. J., Liu, X. S., Shpokayte, M., & Ramirez, S. (2024) · eLife · doi:10.7554/elife.96281.3
Revisiting Hughlings Jackson’s dreamy state: dissociative symptoms in temporal lobe epilepsy
D’Aprano, F., Matson, A., Pieters, J., Eyres, J., Winton‐Brown, T., O'Brien, T. J., Jackson, G. D., Wilson, S. J., Malpas, C. B., & Rayner, G. (2025) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2025.110623
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- Authors
- Rayner, G., Jackson, G., & Wilson, S.
- Affiliations
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Corresponding author
- Rayner, Genevieve
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 61
- Pages
- 53-65
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2208428407
- Cited by
- 104
- References
- 177
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 19 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 4 · 2017: 12 · 2016: 8
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Melbourne School of Psychological Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- major depressive disorder, cognitive control network, rumination, brooding, self-blame, indecision, negative automatic thoughts, attentional bias, vegetative symptoms, affective symptoms, neurocognitive networks, functional neuroimaging
- MeSH terms
- Brain, Cognition, Depression, Major Depressive Disorder, Humans, Nervous System Diseases, Functional Neuroimaging
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