Adolescent risk-taking and resting state functional connectivity
Abstract
The existing literature on the role of emotion regulation circuits (amygdala-prefrontal cortex) in the adolescent brain yields mixed results, particularly on the role of these regions in the context of reward sensitivity and risk-taking behavior sensitivity and risk-taking behavior. Here, we examined functional connectivity in the resting state in 18 risk-taking (RT) adolescents compared with 18 non-risk-taking (NRT) adolescents as defined by the Youth Risk Behavior Surveillance Survey. Separate seed-based correlations with bilateral amygdala and bilateral nucleus accumbens used as the seed were performed to determine functional connectivity using functional magnetic resonance imaging (fMRI). The results showed greater connectivity between the amygdala (seed region) and the right middle frontal gyrus, left cingulate gyrus, left precuneus and right inferior parietal lobule in RT adolescents than in NRT adolescents. Likewise, there was greater connectivity between the nucleus accumbens (seed region) and the right middle frontal gyrus in RT adolescents compared with NRT adolescents. These findings suggest that risk-taking behavior in adolescents is associated with hyperconnectivity during the resting state in networks associated with emotion regulation, reward sensitivity, executive control, and the default mode.
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Some studies have found that same-aged individuals with more well-developed connections between cortical and subcortical areas engage in relatively more risk taking.
“some studies have also found that same-aged individuals with more well-developed connections between cortical and subcortical areas engage in relatively more risk taking (Berns et al., 2009, DeWitt et al., 2014).”
From The dual systems model: Review, reappraisal, and reaffirmation (2016) · cites this paper as DeWitt et al., 2014
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“, 2005) and consistent with the rsFC patterns reported in young adult RT behavior (Cox et al., 2010; DeWitt et al., 2014; Touroutoglou et al., 2014).”
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“Further, risk-taking behaviors in adolescents have been associated with DMN hyperconnectivity during resting state (DeWitt et al., 2014), suggesting that stronger DMN rsFC could contribute to youths ’ impulsivity.”
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“For instance, connectivity changes in key regions of the basal ganglia and the cingulo-opercular network have previously been reported in both risk-taking and risk-averse behaviors (Cox et al., 2010; DeWitt et al., 2014), but changes in these networks were not evident in our study.”
ResultSex differences in limbic network and risk‐taking propensity in healthy individuals
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- Authors
- DeWitt, S. J., Aslan, S., & Filbey, F. M.
- Affiliations
- The University of Texas at Dallas (US)
- Corresponding author
- Filbey, Francesca M.
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 222
- Issue
- 3
- Pages
- 157-164
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2012456149
- Cited by
- 45
- References
- 61
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 1
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Center for Behavioral Brain Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- adolescent risk-taking, resting-state functional connectivity, amygdala, nucleus accumbens, emotion regulation, reward sensitivity, executive function, default mode network, middle frontal gyrus, cingulate gyrus, precuneus, inferior parietal lobule, hyperconnectivity
- MeSH terms
- Adolescent, Adult, Amygdala, Basal Ganglia, Cerebral Cortex, Emotions, Female, Frontal Lobe, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Parietal Lobe, Risk-Taking, Prefrontal Cortex, Executive Function
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