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Disorder-specific functional abnormalities during temporal discounting in youth with Attention Deficit Hyperactivity Disorder (ADHD), Autism and comorbid ADHD and Autism
Open accessAbstract
Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are often comorbid and share cognitive abnormalities in temporal foresight. A key question is whether shared cognitive phenotypes are based on common or different underlying pathophysiologies and whether comorbid patients have additive neurofunctional deficits, resemble one of the disorders or have a different pathophysiology. We compared age- and IQ-matched boys with non-comorbid ADHD (18), non-comorbid ASD (15), comorbid ADHD and ASD (13) and healthy controls (18) using functional magnetic resonance imaging (fMRI) during a temporal discounting task. Only the ASD and the comorbid groups discounted delayed rewards more steeply. The fMRI data showed both shared and disorder-specific abnormalities in the three groups relative to controls in their brain-behaviour associations. The comorbid group showed both unique and more severe brain-discounting associations than controls and the non-comorbid patient groups in temporal discounting areas of ventromedial and lateral prefrontal cortex, ventral striatum and anterior cingulate, suggesting that comorbidity is neither an endophenocopy of the two pure disorders nor an additive pathology.
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“Reduced activation and abnormal brain-behavior correlations during temporal discounting have been observed in ADHD children and adults most prominently in typical areas of temporal discounting including ventrolateral and dorsolateral prefrontal cortices, insular, dorsal and ventral striatal and thalamic regions as well as parietal lobe and cerebellum (Rubia et al., 2009a; Chantiluke et al., 2014;”
From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Chantiluke et al., 2014
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In the citing paper
“The comorbid ADHD and ASD group had the most neurofunctional abnormalities in regions mediating temporal discounting, including ventrolateral and dorsolateral prefrontal, cingulate, striato-insular, temporal and cerebellar regions (Chantiluke et al., 2014).”
From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Chantiluke et al., 2014
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In the citing paper
“and mostly shared between ADHD and ASD in inferior frontal cortex and SMA (Chantiluke et al., 2014).”
From Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation (2018) · cites this paper as Chantiluke et al., 2014
In the citing paper
“These studies demonstrated that children with ASD and comorbid ADHD exhibit functional brain network abnormalities that resemble alterations in children with ASD (without ADHD) and ADHD (without ASD) plus unique abnormalities specific to comorbidity between ASD and ADHD (Di Martino et al., 2013; Chantiluke et al., 2014).”
From Investigating functional brain network integrity using a traditional and novel categorical scheme for neurodevelopmental disorders (2019) · cites this paper as Chantiluke et al., 2014
In the citing paper
“Further, only two prior functional neuroimaging studies considered the impact of comorbidity on diagnostic group differences by examining an ASD with comorbid ADHD group distinct from non-comorbid ASD and ADHD groups (Di Martino et al., 2013; Chantiluke et al., 2014).”
From Investigating functional brain network integrity using a traditional and novel categorical scheme for neurodevelopmental disorders (2019) · cites this paper as Chantiluke et al., 2014
In the citing paper
“These disorders exhibit shared deficits in executive function (Leno et al., 2017) and associated functional brain alterations (Di Martino et al., 2013; Chantiluke et al., 2014)”
From Investigating functional brain network integrity using a traditional and novel categorical scheme for neurodevelopmental disorders (2019) · cites this paper as Chantiluke et al., 2014
In the citing paper
“Importantly, Chantiluke et al. (2014) showed that children with “pure” ASD and ADHD exhibited little to no disorder-specific functional alterations during a temporal discounting task, whereas the comorbid group exhibited pronounced functional differences compared with all other groups (Chantiluke et al., 2014).”
From Investigating functional brain network integrity using a traditional and novel categorical scheme for neurodevelopmental disorders (2019) · cites this paper as Chantiluke et al., 2014
In the citing paper
“A few studies 23–25 reveal that those with ASD have altered performance on delayed reward discounting tasks.”
From Subtyping cognitive profiles in Autism Spectrum Disorder using a Functional Random Forest algorithm (2018) · cites this paper as [25]
In the citing paper
“Inhibitory problems seem to be shared by the group with ASD+ADHD and the group with ADHD (Bühler et al., 2011;Chantiluke et al., 2014;Sinzig et al., 2008b;Tye et al., 2014), although sometimes no inhibitory deficits have been found in the comorbid group (Sinzig et al., 2008a;Van der Meer et al., 2012;Yerys et al., 2009).”
From Children with autism and attention deficit hyperactivity disorder. Relationships between symptoms and executive function, theory of mind, and behavioral problems (2018) · cites this paper as Chantiluke et al., 2014
In the citing paper
“The findings are framed within the line of research that shows greater impairment in the executive functioning of children with ASD+ADHD and ADHD alone, compared to children with ASD (Adamo et al., 2014;Bühler et al., 2011;Chantiluke et al., 2014;Lundervold et al., 2016;Sinzig et al., 2008b;Tye et al., 2014).”
From Children with autism and attention deficit hyperactivity disorder. Relationships between symptoms and executive function, theory of mind, and behavioral problems (2018) · cites this paper as Chantiluke et al., 2014
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Metadata
- Authors
- Chantiluke, K., Christakou, A., Murphy, C. M., Giampietro, V., Daly, E. M., Ecker, C., Brammer, M., Murphy, D. G., & Rubia, K.
- Affiliations
- King's College London (GB)
- University of Reading (GB)
- ORCID
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 223
- Issue
- 2
- Pages
- 113-120
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W1995696366
- Cited by
- 116
- References
- 55
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 12 · 2023: 8 · 2022: 5 · 2021: 6 · 2020: 14 · 2019: 11 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 7 · 2014: 1
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Psychiatry Research Neuroimaging (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- Funders
- Medical Research Council (MRC GO300155)
- MRC UK Autism Imaging Multicentre Study (G0400061)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- delay discounting, attention deficit hyperactivity disorder, autism spectrum disorder, delayed rewards, prefrontal cortex, ventral striatum, anterior cingulate cortex, brain-behavior relationship
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Brain, Child, Child Development Disorders, Pervasive, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Reward, Comorbidity, Case-Control Studies, Prefrontal Cortex, Delay Discounting
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