Binge eating disorder and morbid obesity are associated with lowered mu-opioid receptor availability in the brain
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Both morbid obesity and binge eating disorder (BED) have previously been linked with aberrant brain opioid function. Behaviorally these two conditions are however different suggesting also differences in neurotransmitter function. Here we directly compared mu-opioid receptor (MOR) availability between morbidly obese and BED subjects. Seven BED and nineteen morbidly obese (non-BED) patients, and thirty matched control subjects underwent positron emission tomography (PET) with MOR-specific ligand [11 C]carfentanil. Both subjects with morbid obesity and BED had widespread reduction in [11 C]carfentanil binding compared to control subjects. However, there was no significant difference in brain MOR binding between subjects with morbid obesity and BED. Thus, our results indicate that there is common brain opioid abnormality in behaviorally different eating disorders involving obesity.
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Reduced MOR across binge eating disorder, obesity, and SUDs strongly suggests neurochemical overlap in these conditions, and this can persist despite weight loss or periods of drug abstinence.
“Meanwhile, reduced MOR has been observed in comorbid binge eating disorder and obesity [191] and across SUDs [144] which strongly suggest neurochemical overlap in these conditions, and which can persist despite weight loss or periods of drug abstinence.”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [191]
Reduced MOR has been observed in comorbid binge eating disorder and obesity and across SUDs.
“Meanwhile, reduced MOR has been observed in comorbid binge eating disorder and obesity [191] and across SUDs [144] which strongly suggest neurochemical overlap in these conditions, and which can persist despite weight loss or periods of drug abstinence.”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [191]
Individuals with obesity and binge eating disorder have widespread reduction in binding at mu-opioid receptors, in addition to deficiencies identified at striatal dopamine D2 receptors.
“In addition to deficiencies identified at striatal DA-D2 receptors [89,90], individuals with obesity and BED have widespread reduction in binding at mu-opioid receptors (MOR) [91].”
From Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint (2020) · cites this paper as [91]
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- Authors
- Joutsa, J., Karlsson, H. K., Majuri, J., Nuutila, P., Helin, S., Kaasinen, V., & Nummenmaa, L.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University of Turku (FI)
- Corresponding author
- Joutsa, Juho
- ORCID
- Venue
- Psychiatry Research Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 276
- Pages
- 41-45
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2791824613
- Cited by
- 35
- References
- 37
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 12 · 2019: 6 · 2018: 1
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.utupub.fi
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- UTUPub (University of Turku) (submittedVersion)
- Funders
- Academy of Finland (#304385, #256836, #295580)
- Finnish Medical Foundation
- Finnish Alcohol Research Foundation
- Turku University Hospital
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- binge eating disorder, morbid obesity, mu-opioid receptor, [11C]carfentanil, eating disorders
- MeSH terms
- Adult, Analgesics, Opioid, Brain, Female, Fentanyl, Humans, Male, Middle Aged, Obesity, Morbid, Receptors, Opioid, mu, Positron-Emission Tomography, Binge-Eating Disorder
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