Effects of intravenous glucose on dopaminergic function in the human brain in vivo
Abstract
Dopamine is known to regulate food intake by modulating food reward via the mesolimbic circuitry of the brain. The objective of this study was to compare the effects of high energy input (i.v. glucose) on striatal and thalamic dopamine release in overweight and lean individuals. We hypothesized that glucose would induce dopamine release and positive ratings (e.g., satiety) in Behavioral Analog Scales, particularly in food‐deprived lean subjects. [11 C]raclopride PET was performed for 12 lean (mean BMI = 22 kg/m 2) and 12 overweight (mean BMI = 33 kg/m 2) healthy subjects. Each subject was imaged twice in a blinded counter‐balanced setting, after 300 mg/kg i.v. glucose and after i.v. placebo. Dopamine D2 receptor binding potentials (BPs) were estimated. The voxel‐based analysis of the baseline scans indicated lower striatal BPs in the overweight group and a negative correlation between BMIs and BPs. Intravenous glucose did not have a significant effect on BPs in overweight or lean subjects (male and female groups combined). However, BP changes were opposite in the two gender groups. In male subjects, significant BP reductions after glucose were seen in the right and left caudate nucleus, left putamen, and right thalamus. In female subjects, increases in BP secondary to glucose were seen in the right caudate nucleus and right and left putamen. The sexually dimorphic effect of glucose was seen in both overweight and lean subjects. Although gender differences were not among the a priori hypotheses of the present study and, therefore, they must be considered to be preliminary findings, we postulate that this observation is a reflection of an interaction between glucose, sex steroids (estrogen), leptin, and dopamine. Synapse 61:748–756, 2007. © 2007 Wiley‐Liss, Inc.
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Negative correlation between BMI and striatal D2R in obese and overweight individuals, and correlation between BMI and decreased prefrontal blood flow in healthy individuals and decreased prefrontal metabolism in obese subjects, support this.
“the negative correlation between BMI and striatal D2R reported in obese (81) and in overweight (96) individuals, as well as the correlation between BMI and decreased blood flow in prefrontal regions in healthy individuals (97,98) and decreased prefrontal metabolism in obese subjects (63) support this.”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [96]
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“We studied only females, while other reports included both males and females (5,21).”
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- Authors
- Haltia, L. T., Rinne, J. O., Merisaari, H., Maguire, R. P., Savontaus, E., Helin, S., Någren, K., & Kaasinen, V.
- Affiliations
- University of Turku (FI)
- Turku PET Centre (FI)
- University of Groningen (NL)
- Corresponding author
- Haltia, Lauri T.
- ORCID
- Venue
- Synapse
- Publisher
- Wiley
- Published
- 2007-06-13
- Volume
- 61
- Issue
- 9
- Pages
- 748-756
- ISSN
- 0887-4476 (ISSN-L)
- 1098-2396
- OpenAlex
- W2106411247
- Cited by
- 148
- References
- 43
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 16 · 2014: 16 · 2013: 11 · 2012: 9
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Synapse (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- intravenous glucose, dopamine release, striatum, thalamus, obesity, overweight, sex differences, food reward, food intake regulation, caudate nucleus, putamen, leptin, sex steroids, estrogen, satiety
- MeSH terms
- Adult, Analysis of Variance, Binding, Competitive, Brain, Brain Mapping, Dopamine, Double-Blind Method, Female, Glucose, Humans, Image Processing, Computer-Assisted, Injections, Intravenous, Male, Sex Factors, Sweetening Agents, Tomography, Emission-Computed, Dopamine Antagonists, Raclopride, Overweight
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