Cited by 118Treatment of Major DepressionNerve injury and regenerationStress Responses and Cortisol

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The acute response of plasma brain-derived neurotrophic factor as a result of exercise in major depressive disorder.

Gustafsson, Gunnar, Lira, Claudia Mallea, Johansson, Jon, Wisén, Anita, Wohlfart, Björn, Ekman, Rolf, Westrin, Åsa·2009·Psychiatry Research

DOI 10.1016/j.psychres.2008.06.030

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Abstract

Brain-derived neurotrophic factor (BDNF) and other neurotrophins are believed to play an important role in affective disorders. In this study we investigated plasma-BDNF response during an incremental exercise test in 18 patients suffering from moderate major depressive disorder (MDD) and 18 controls. The patients were not treated with antidepressants or neuroleptics. Possible associations between plasma plasma-BDNF levels, dexamethasone suppression test cortisol levels and Montgomery-Asberg Depression Rating Scale (MADRS) scores were also tested. No difference in basal BDNF levels between patients and controls was found. BDNF increased significantly during exercise in both male and female patients as well as in male controls, with no significant differences between the groups. BDNF levels declined after exercise, but after 60 min of rest BDNF levels showed tendencies to increase again in male patients. No correlation between BDNF and cortisol or MADRS scores was found. We conclude that unmedicated patients with moderate depression and normal activity of the hypothalamic-pituitary-adrenal axis do not have a disturbed peripheral BDNF release during exercise. The BDNF increase 60 min after interruption of exercise in male patients might indicate up-regulated BDNF synthesis, but this needs to be further investigated in future studies.

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Authors: Gustafsson, G., Lira, C. M., Johansson, J., Wisén, A., Wohlfart, B., Ekman, R., & Westrin, Å.
Affiliations: Skåne University Hospital (SE)
Lund University (SE)
University of Gothenburg (SE)
Corresponding author: Gustafsson, Gunnar
ORCID: Ekman, Rolf
Westrin, Åsa
Venue: Psychiatry Research
Publisher: Elsevier BV
Published: 2009-10
Volume: 169
Issue: 3
Pages: 244-248
ISSN: 0165-1781 (ISSN-L)
DOI: 10.1016/j.psychres.2008.06.030
OpenAlex: W2067350830
Cited by: 118
References: 27
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 4 · 2015: 13 · 2014: 10 · 2013: 11 · 2012: 9
FWCI: 5.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: brain-derived neurotrophic factor, major depressive disorder, acute exercise, incremental exercise test, plasma BDNF, neurotrophins, hypothalamic-pituitary-adrenal axis, cortisol, dexamethasone suppression test, mood disorders
MeSH terms: Adult, Major Depressive Disorder, Dexamethasone, Enzyme-Linked Immunosorbent Assay, Exercise Therapy, Female, Humans, Hydrocortisone, Male, Middle Aged, Psychiatric Status Rating Scales, Sex Factors, Time Factors, Case-Control Studies, Brain-Derived Neurotrophic Factor, Young Adult

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The acute response of plasma brain-derived neurotrophic factor as a result of exercise in major depressive disorder.

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