Acute Aerobic Exercise Increases Brain-Derived Neurotrophic Factor Levels in Elderly with Alzheimer's Disease
Abstract
Studies indicate the involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of Alzheimer's disease (AD). Decreased BDNF levels may constitute a lack of trophic support and contribute to cognitive impairment in AD. The benefits of acute and chronic physical exercise on BDNF levels are well-documented in humans, however, exercise effects on BDNF levels have not been analyzed in older adults with AD. The aim of this study was to investigate the effects of acute aerobic exercise on BDNF levels in older adults with AD and to verify associations among BDNF levels, aerobic fitness, and level of physical activity. Using a controlled design, twenty-one patients with AD (76.3 ± 6.2 years) and eighteen healthy older adults (74.6 ± 4.7 years) completed an acute aerobic exercise. The outcomes included measures of BDNF plasma levels, aerobic fitness (treadmill grade, time to exhaustion, VO2, and maximal lactate) and level of physical activity (Baecke Questionnaire Modified for the Elderly). The independent t-test shows differences between groups with respect to the BDNF plasma levels at baseline (p = 0.04; t = 4.53; df = 37). In two-way ANOVA, a significant effect of time was found (p = 0.001; F = 13.63; df = 37), the aerobic exercise significantly increased BDNF plasma levels in AD patients and healthy controls. A significant correlation (p = 0.04; r = 0.33) was found between BDNF levels and the level of physical activity. The results of our study suggest that aerobic exercise increases BDNF plasma levels in patients with AD and healthy controls. In addition to that, BDNF levels had association with level of physical activity.
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Physical activity augments neuronal protection in brain disorders by stimulating BDNF expression.
“These studies indeed indicated that physical activity augments neuronal protection in brain disorders by stimulating BDNF expression.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [216]
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- Authors
- Coelho, F. G. D. M., Vital, T. M., Stein, A. M., Arantes, F. J., Rueda, A. V., Camarini, R., Teodorov, E., & Santos-Galduróz, R. F.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity and Aging Lab (LAFE), Rio Claro, SP, Brazil
- Universidade de São Paulo (BR)
- Universidade Federal do ABC (BR)
- ORCID
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2014-01-24
- Volume
- 39
- Issue
- 2
- Pages
- 401-408
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1843108425
- Cited by
- 203
- References
- 30
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 19 · 2023: 18 · 2022: 14 · 2021: 17 · 2020: 19 · 2019: 17 · 2018: 12 · 2017: 17 · 2016: 27 · 2015: 16 · 2014: 8 · 2013: 1
- FWCI
- 17.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- brain-derived neurotrophic factor, Alzheimer's disease
- MeSH terms
- Aged, Alzheimer Disease, Analysis of Variance, Cognition Disorders, Humans, Physical Fitness, Psychiatric Status Rating Scales, Surveys and Questionnaires, Exercise, Brain-Derived Neurotrophic Factor
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