Poor sleep quality predicts onset of either major depression or subsyndromal depression with irritability during interferon-alpha treatment
Open accessAbstract
Major depressive disorder (MDD) often occurs during pegylated IFN-alpha2 (IFN-alpha) treatment. Identifying who is at risk for MDD in this population is essential, and epidemiological studies suggest that sleep may be related to depression risk. Controlling for pre-existing depression symptoms, we therefore examined whether sleep quality prior to IFN-alpha treatment would predict subsequent MDD incidence during IFN-alpha treatment. Adults with hepatitis C but without current clinical MDD (n=86) were evaluated prior to IFN-alpha treatment and then prospectively monitored during treatment using self-report measures of sleep quality (PSQI), depression (BDI), and anger and irritability (AIAQ), as well as with Structured Clinical Interviews for DSM-IV Axis I Disorders (SCID-I). During IFN-alpha treatment, 19% developed MDD, 19% developed subsyndromal depression with irritability, and one developed mania. Controlling for baseline depression symptoms and past history of depression, patients with worse sleep quality (PSQI > or = 10) prior to treatment had a significantly shorter time until they developed MDD or any severe psychiatric problem. These findings may have important implications for understanding, predicting, and possibly preventing depression, particularly in individuals treated with IFN-alpha.
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Self-reported sleep disturbance predicted onset of depression during interferon-alpha treatment.
“self-reported sleep disturbance predicted the onset of depression during interferon-α treatment (Franzen et al, 2010).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Franzen et al, 2010
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- Authors
- Franzen, P. L., Buysse, D. J., Rabinovitz, M., Pollock, B. G., & Lotrich, F. E.
- Affiliations
- University of Pittsburgh (US)
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Franzen, Peter L.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 177
- Issue
- 1-2
- Pages
- 240-245
- ISSN
- 0165-1781 (ISSN-L)
- PMC
- PMC2861158
- OpenAlex
- W2056602748
- Cited by
- 62
- References
- 59
- Citations by year
- 2023: 3 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 9
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- Medical Center, University of Pittsburgh
- National Institute of Mental Health (K01MH077106, MH74012, K24MH065416, MH 65416, K23MH074012, MH77106)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- sleep quality, major depressive disorder, subthreshold depression, irritability, anger, interferon-alpha, pegylated interferon, hepatitis C, mania
- MeSH terms
- Adult, Analysis of Variance, Depressive Disorder, Major, Major Depressive Disorder, Female, Follow-Up Studies, Health Surveys, Humans, Immunologic Factors, Irritable Mood, Male, Middle Aged, Sleep Wake Disorders, Time Factors, Proportional Hazards Models, Interferon-alpha, Kaplan-Meier Estimate
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