Respiratory sinus arrhythmia: noninvasive measure of parasympathetic cardiac control
Abstract
The degree of parasympathetic heart rate control, PC, was defined as the decrease in average heart period (RR interval) caused by the elimination of parasympathetically mediated influences on the heart while keeping sympathetic activity unchanged. By reviewing published results on the interaction of sympathetic and parasympathetic heart rate control, the prediction was made that PC should be directly proportional to VHP, the peak-to-peak variations in heart period caused by spontaneous respiration. In sevel chloralose/urethan-anesthetized dogs the vagi were reversibly blocked by cooling, and PC (the difference between average heart period before and after cooling) and VHP (without cooling) were determined under a variety of conditions that included a) increasing vagal activity by elevating the blood pressure b) sympathetic blockade, and c) parasympathetic blockade. The relationship between VHP and PC was linear with an average correlation coefficient of 0.969 +/- 0.024 (SD) and a PC-axis intercept of 15.2 +/- 25.9 ms. In each dog the correlation coefficient between VHP and PC was higher than between VHP and the average heart period (avg correlation coef: 0.914 +/- 0.044). These results suggest that the degree of respiratory sinus arrhythmia may be used as a noninvasive indicator of the degree of parasympathetic cardiac control.
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Respiratory sinus arrhythmia measures vagal modulations on heart rate and is correlated with the activity of the parasympathetic nervous system.
“A measure that is associated with HF is the respiratory sinus arrhythmia (RSA), which measures vagal modulations on heart rate and is correlated with the activity of the parasympathetic nervous system [50, 51].”
From The Influence of Buddhist Meditation Traditions on the Autonomic System and Attention (2015) · cites this paper as [51]
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- Authors
- Katona, P. G., & Jih, F.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1975-11-01
- Volume
- 39
- Issue
- 5
- Pages
- 801-805
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2142700313
- Cited by
- 792
- References
- 0
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 13 · 2021: 20 · 2020: 19 · 2019: 13 · 2018: 13 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 11 · 2013: 25 · 2012: 10
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- respiratory sinus arrhythmia, heart rate variability, vagal cooling, vagotomy, sympathetic nerve block, parasympathetic blockade, parasympathetic activity, dogs
- MeSH terms
- Animals, Arrhythmia, Sinus, Dogs, Female, Heart, Heart Rate, Male, Mathematics, Respiration, Sympathetic Nervous System, Vagus Nerve
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