Quality of life in schizophrenia spectrum disorders: Associations with insight and psychopathology
Abstract
Therapeutic interventions in chronic mental illness face the important challenge to pursuit the quality of life (QOL) of patients. Insight into chronic mental illness, though a prerequisite for treatment adherence and a positive therapeutic outcome, has shown adverse associations with subjective QOL. This study aims to explore the contribution of psychopathological symptoms on the ambiguous role of insight on QOL. Seventy-two outpatients with schizophrenia spectrum disorders were assessed using the positive and negative syndrome scale, the scale to assess unawareness of mental disorder, and the WHOQOL-100 instrument for the assessment of quality of life. Insight was found to associate inversely with quality of life. Among psychopathological symptoms, depressive symptoms were the strongest negative contributor on QOL. Mediation analysis revealed that the effects of awareness of the consequences of illness on QOL were largely mediated by depressive symptoms (full mediation for the effect on physical and psychological domain and partial mediation for the effect on independence and environment domain of the QOL). Our results suggest that the inverse relationship between insight and subjective quality of life is partially mediated by depressive symptoms. We discuss theoretical and therapeutic implications of the findings, in conjunction with similar recent research data.
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Good clinical insight predicts lower self-reported quality of life, with that relationship mediated by depression.
“Good clinical insight has also been found to predict lower self-reported quality of life 80 , with that relationship mediated by depression, suggesting that good insight may trigger depression, which may then degrade quality of life 80 .”
From Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments (2018) · cites this paper as [80]
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- Authors
- Margariti, M., Ploumpidis, D., Economou, M., Christodoulou, G. N., & Papadimitriou, G. N.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Margariti, Maria
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 225
- Issue
- 3
- Pages
- 695-701
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2019305049
- Cited by
- 41
- References
- 59
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 4
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Clinical Psychology › Family Caregiving in Mental Illness
- Keywords
- quality of life, schizophrenia spectrum disorders, insight, depressive symptoms, awareness of mental disorder, psychiatric symptoms, mediation, medication adherence, chronic mental illness, WHOQOL-100
- MeSH terms
- Adolescent, Adult, Awareness, Depression, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Psychopathology, Psychotic Disorders, Quality of Life, Schizophrenia, Schizophrenic Psychology, Statistics as Topic, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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