Cited by 330Child Abuse and TraumaStress Responses and CortisolHealth disparities and outcomes

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Childhood adversity and inflammatory processes in youth: A prospective study

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Slopen, Natalie, Kubzansky, Laura D., McLaughlin, Katie A., Koenen, Karestan C.·2013·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2012.05.013PMC PMC3632283

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Abstract

Background Retrospective studies show that childhood adversity is associated with systemic inflammation in adulthood. Few prospective studies have examined whether childhood adversity influences inflammation in an observable manner during childhood or adolescence and if these effects are sustained over time.Methods Using longitudinal data from the Avon Longitudinal Study of Parents and Children, we examined associations between acute adverse events at seven time points prior to age 8 and inflammation at ages 10 and 15. Inflammatory markers at age 10 included interleukin-6 (IL-6; N=4655) and C-reactive protein (CRP; N=4647), and CRP was measured again at age 15 (N=3286). We further evaluated whether body mass index (BMI), depression, or cigarette smoking mediated associations between adverse events and inflammation.Results Adverse events in middle childhood (occurring between ages 6 to 8), as well as cumulative adversity from birth to 8 years, were associated with higher levels of IL-6 and CRP at age 10. Adverse events reported in early childhood (1.5years) or middle childhood, and cumulative adversity from birth through 8years predicted increased levels of CRP at age 15, and these associations persisted after adjustment for CRP at age 10. Some, but not all, of these associations were mediated by BMI.Conclusions This study documents that exposure to adverse events prior to age 8 is associated with elevated inflammation at age 10 and in mid-adolescence. These findings provide prospective evidence for a biological mechanism by which early experiences may shape long-term health. Future studies with earlier assessments of inflammation are necessary in order to elucidate potential sensitive periods and mechanisms that link childhood adversity to later disease vulnerability.

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Self-citation

Authors: Slopen, N., Kubzansky, L. D., McLaughlin, K. A., & Koenen, K. C.
Affiliations: Harvard University (US)
Boston Children's Hospital (US)
Columbia University (US)
Corresponding author: Slopen, Natalie
ORCID: Slopen, Natalie
Kubzansky, Laura D.
McLaughlin, Katie A.
Koenen, Karestan C.
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2013-02
Volume: 38
Issue: 2
Pages: 188-200
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2012.05.013
PMC: PMC3632283
OpenAlex: W2086951593
Cited by: 330
References: 74
Citations by year: 2026: 15 · 2025: 17 · 2024: 26 · 2023: 35 · 2022: 24 · 2021: 29 · 2020: 32 · 2019: 30 · 2018: 20 · 2017: 23 · 2016: 22 · 2015: 20 · 2014: 21 · 2013: 14
FWCI: 20.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: UK Medical Research Council (74882)
Wellcome Trust (076467)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Health › Health disparities and outcomes
Keywords: childhood adversity, systemic inflammation, interleukin-6, C-reactive protein, cumulative adversity, middle childhood, adolescence, body mass index, depression, cigarette smoking, mediation, sensitive period, Avon Longitudinal Study of Parents and Children
MeSH terms: Adolescent, Age Factors, C-Reactive Protein, Child, Depression, Female, Humans, Life Change Events, Male, Prospective Studies, Interleukin-6, Body Mass Index, Inflammation Mediators

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Childhood adversity and inflammatory processes in youth: A prospective study

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