Future directions in the study of early-life stress and physical and emotional health: implications of the neuroimmune network hypothesis.

Hostinar, Camelia E.; Nusslock, Robin; Miller, Gregory E.

doi:10.1080/15374416.2016.1266647

Cited by 90Stress Responses and CortisolChild Abuse and TraumaTryptophan and brain disorders

Future directions in the study of early-life stress and physical and emotional health: implications of the neuroimmune network hypothesis.

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Hostinar, Camelia E., Nusslock, Robin, Miller, Gregory E.·2018·Journal of Clinical Child & Adolescent Psychology

DOI 10.1080/15374416.2016.1266647PMC PMC6100778

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Abstract

Early-life stress is associated with increased vulnerability to physical and emotional health problems across the lifespan. The recently developed neuroimmune network hypothesis proposes that one of the underlying mechanisms for these associations is that early-life stress amplifies bidirectional crosstalk between the brain and the immune system, contributing to several mental and physical health conditions that have inflammatory underpinnings, such as depression and coronary heart disease. Neuroimmune crosstalk is thought to perpetuate inflammation and neural alterations linked to early-life stress exposure, and also foster behaviors that can further compromise health, such as smoking, drug abuse and consumption of high-fat diets. The goal of the present review is to briefly summarize the neuroimmune network hypothesis and use it as a starting point for generating new questions about the role of early-life stress in establishing a dysregulated relationship between neural and immune signaling, with consequences for lifespan physical and emotional health. Specifically, we aim to discuss implications and future directions for theory and empirical research on early-life stress, as well as for interventions that may improve the health and well-being of children and adolescents living in adverse conditions.

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Early life adversity is a chronic and severe stressor causing long-lasting psychological and biological abnormalities that considerably increase the risk of depression.
“ELA is considered as a chronic and severe stressor causing long-lasting psychological and biological abnormalities that considerably increase the risk of depression (Hostinar et al., 2018).”
From The interplay between stress, inflammation, and emotional attention: relevance for depression (2019) · cites this paper as Hostinar et al., 2018
The "neuroimmune network hypothesis" proposes that ELA amplifies the communication between the brain and the immune system, promoting low grade peripheral inflammation.
“The “neuroimmune network hypothesis” proposes that ELA amplifies the communication between the brain and the immune system, promoting low grade peripheral inflammation [122].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [122]

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Authors: Hostinar, C. E., Nusslock, R., & Miller, G. E.
Affiliations: University of California, Davis (US)
Northwestern University (US)
Corresponding author: Hostinar, Camelia E.
ORCID: Hostinar, Camelia E.
Nusslock, Robin
Miller, Gregory E.
Venue: Journal of Clinical Child & Adolescent Psychology
Publisher: Informa UK Limited
Published: 2017-01-20
Volume: 47
Issue: 1
Pages: 142-156
ISSN: 1537-4416 (ISSN-L)
1537-4424
DOI: 10.1080/15374416.2016.1266647
PMC: PMC6100778
OpenAlex: W2572674047
Cited by: 90
References: 136
Citations by year: 2026: 8 · 2025: 4 · 2024: 10 · 2023: 6 · 2022: 13 · 2021: 13 · 2020: 13 · 2019: 13 · 2018: 8 · 2017: 2
FWCI: 5.36
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: doi.org/10.1080/policies-text-data-mining (tdm)
Locations: Journal of Clinical Child & Adolescent Psychology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (F32 HD078048,P30 DA027827,R01 HD058502,R01 MH077908,R01 MH100117)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: early life stress, neuroimmune interactions, inflammation, depression, coronary artery disease, smoking, drug abuse, high-fat diet, adverse childhood experiences, child and adolescent health, health interventions
MeSH terms: Adolescent, Child, Emotions, Female, Humans, Male, Mental Health, Stress, Psychological

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Future directions in the study of early-life stress and physical and emotional health: implications of the neuroimmune network hypothesis.

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