Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms
Abstract
Postmenopausal women may be more vulnerable to cognitive loss and Alzheimer's disease (AD) than premenopausal women because of their deficiency in estrogens, in addition to their usually older age. Aerobic physical exercise has been proposed as a therapeutic approach for maintaining health and well-being in postmenopausal women, and for improving brain health and plasticity in populations at high risk for AD. To study the neuroprotective mechanisms of physical exercise in a postmenopausal animal model, we submitted previously ovariectomized, six-month old non-transgenic and 3xTg-AD mice to three months of voluntary exercise in a running wheel. At nine months of age, we observed lower grip strength and some exacerbation of the behavioral and psychological symptoms of dementia (BPSD)-like involving active exploratory activities. A similar major cognitive impairment was observed of ovariectomized 3xTg-AD mice in comparison with sham-operated 3xTg-AD mice. A reduction of bodily fitness and lack of retention of memory were observed in the ovariectomized non-transgenic mice. Physical exercise protected against all deleterious behaviors and normalized learning and memory. It also protected against body frailty, as expected. Analyses of hippocampal key markers of antioxidant and neuroplasticity signaling pathways, showed that ovariectomy impairs the activation of CREB through physical exercise. Furthermore, molecular and behavioral correlates suggested a central role of BDNF in the neuroprotection mediated by physical exercise therapy against apathy and memory loss induced by ovariectomy and the AD-genotype.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Physical activity augments neuronal protection in brain disorders by stimulating BDNF expression.
“These studies indeed indicated that physical activity augments neuronal protection in brain disorders by stimulating BDNF expression.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [214]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works
Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739 · see citing works
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268 · see citing works
Heyn, P., Abreu, B. C., & Ottenbacher, K. J. (2004) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2004.03.019 · Cited by 1,223 · see citing works
Angevaren, M., Aufdemkampe, G., Verhaar, H., Aleman, A., & Vanhees, L. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005381.pub3 · Cited by 1,130 · see citing works
Yao, J., Irwin, R. W., Zhao, L., Nilsen, J., Hamilton, R. T., & Brinton, R. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903563106 · Cited by 940 · see citing works
A Prospective Study of Physical Activity and Cognitive Decline in Elderly Women: Women Who Walk
Yaffe, K., Barnes, D., Nevitt, M., Lui, L.-Y., & Covinsky, K. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.14.1703 · Cited by 921 · see citing works
Erickson, K. I., Miller, D. L., & Roecklein, K. A. (2011) · The Neuroscientist · doi:10.1177/1073858410397054 · Cited by 550 · see citing works
Angevaren, M., Aufdemkampe, G., Verhaar, H. J. J., Aleman, A., & Vanhees, L. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005381.pub2 · Cited by 436 · see citing works
Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines
Cheng, A., Wan, R., Yang, J.-L., Kamimura, N., Son, T. G., Ouyang, X., Luo, Y., Okun, E., & Mattson, M. P. (2012) · Nature Communications · doi:10.1038/ncomms2238 · Cited by 401 · see citing works
Regular exercise improves cognitive function and decreases oxidative damage in rat brain
Radak, Z. O., Kaneko, T., Tahara, S., Nakamoto, H., Pucsok, J. M., Sasvári, M., Nyakas, C. J., & Goto, S. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00063-2 · Cited by 373 · see citing works
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease
Resende, R., Moreira, P. I., Proença, T., Deshpande, A., Busciglio, J., Pereira, C., & Oliveira, C. R. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.012 · Cited by 343 · see citing works
Is the Risk of Developing Alzheimer's Disease Greater for Women than for Men?
Hebert, L. E., Scherr, P. A., McCann, J. J., Beckett, L. A., & Evans, D. A. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.2.132 · Cited by 331 · see citing works
The role of CREB signaling in Alzheimer’s disease and other cognitive disorders
Saura, C. A., & Valero, J. (2011) · revneuro · doi:10.1515/rns.2011.018 · Cited by 312 · see citing works
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease
Intlekofer, K. A., & Cotman, C. W. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.06.011 · Cited by 286 · see citing works
The exercise-induced expression of BDNF within the hippocampus varies across life-span
Adlard, P. A., Perreau, V. M., & Cotman, C. W. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.05.006 · Cited by 260 · see citing works
Physical Exercise Protects Against Alzheimer's Disease in 3xTg-AD Mice
García‐Mesa, Y., López, J. C., Giménez‐Llort, L., Revilla, S., Guerra, R., Gruart, A., LaFerla, F. M., Cristòfol, R. M., Delgado-Garcia, J. M., & Sanfeliu, C. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101635 · Cited by 253 · see citing works
Self-citationCaccamo, A., Maldonado, M. A., Bokov, A. F., Majumder, S., & Oddo, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012851108 · Cited by 249 · see citing works
Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges
Kamat, C. D., Gadal, S., Mhatre, M., Williamson, K. S., Pye, Q. N., & Hensley, K. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15314 · Cited by 237 · see citing works
Giménez‐Llort, L., Blázquez, G., Cañete, T., Johansson, B. A., Oddo, S., Tobeña, A., LaFerla, F. M., & Fernández‐Teruel, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.007 · Cited by 232 · see citing works
Self-citationLauritzen, I., Pardossi-Piquard, R., Bauer, C., Brigham, E., Abraham, J.-D., Ranaldi, S., Fraser, P., St-George-Hyslop, P., Le Thuc, O., Espin, V., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2775-12.2012 · Cited by 201 · see citing works
Gray, S. L., Anderson, M. L., Hubbard, R. A., LaCroix, A. Z., Crane, P. K., McCormick, W. C., Bowen, J. D., McCurry, S. M., & Larson, E. B. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt013 · Cited by 191 · see citing works
Gender, cognitive decline, and risk of AD in older persons
Barnes, L. L., Wilson, R. S., Schneider, J. A., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2003) · Neurology · doi:10.1212/01.wnl.0000065892.67099.2a · Cited by 173 · see citing works
Females Live Longer than Males: Role of Oxidative Stress
Viña, J., Gambini, J., López-Grueso, R., Abdelaziz, K. M., Jové, M., & Borrás, C. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798764942 · Cited by 170 · see citing works
Self-citationCognitive and behavioural effects of physical exercise in psychiatric patients
Knöchel, C., Oertel‐Knöchel, V., O’Dwyer, L., Prvulovic, D., Alves, G. S., Kollmann, B., & Hampel, H. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.11.007 · Cited by 164 · see citing works
Rocca, W. A., Cha, R. H., Waring, S. C., & Kokmen, E. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009560 · Cited by 160 · see citing works
Hormone therapy, dementia, and cognition: the Women's Health Initiative 10 years on
Maki, P. M., & Henderson, V. W. (2012) · Climacteric · doi:10.3109/13697137.2012.660613 · Cited by 145 · see citing works
Viña, J. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.02.013 · Cited by 142 · see citing works
Self-citationFranklin, T. B., & Perrot-Sinal, T. S. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.05.008 · Cited by 134 · see citing works
Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid
Yao, J., Irwin, R. W., Chen, S., Hamilton, R., Cadenas, E., & Brinton, R. D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.001 · Cited by 133 · see citing works
Regulation of local translation at the synapse by BDNF
Santos, A. R., Comprido, D., & Duarte, C. B. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.004 · Cited by 122 · see citing works
Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse
García‐Mesa, Y., Giménez‐Llort, L., López, L. C., Venegas, C., Cristòfol, R. M., Escames, G., Acuña-Castroviejo, D., & Sanfeliu, C. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.11.016 · Cited by 118 · see citing works
Self-citationThe Unique Relation of Physical Activity to Executive Function in Older Men and Women
Bixby, W. R., Spalding, T. W., Haufler, A. J., Deeny, S. P., Mahlow, P., Zimmerman, J. B., & Hatfield, B. D. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31806ad708 · Cited by 107 · see citing works
Spatial cognition in humans: possible modulation by androgens and estrogens.
Hampson, E. (1995) · PubMed · Cited by 105 · see citing works
Baeza, I., Castro, N. M. D., Giménez‐Llort, L., & la Fuente, M. D. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.12.008 · Cited by 97 · see citing works
Self-citationScharfman, H. E., & MacLusky, N. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.029 · Cited by 93 · see citing works
Giménez-Llort, L., Arranz, L., Maté, I., & De la Fuente, M. (2008) · Neuroimmunomodulation · doi:10.1159/000156475 · Cited by 91 · see citing works
Self-citationCarroll, J. C., Rosario, E. R., Villamagna, A. H., & Pike, C. J. (2010) · Endocrinology · doi:10.1210/en.2009-1487 · Cited by 91 · see citing works
Müller, M., Cárdenas, C., Mei, L., Cheung, K., & Foskett, J. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109297108 · Cited by 86 · see citing works
Symptomatic and Nonamyloid/Tau Based Pharmacologic Treatment for Alzheimer DiseasePreprint
Aisen, P. S. S., Cummings, J. L., & Schneider, L. S. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006395 · Cited by 82 · see citing works
Estrogens and memory in physiological and neuropathological conditions
Pompili, A., Arnone, B., & Gasbarri, A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.007 · Cited by 81 · see citing works
Aerobic exercise interacts with neurotrophic factors to predict cognitive functioning in adolescents
Lee, T. M. C., Wong, M. L., Lau, B. W.-M., Lee, J. C.-D., Yau, S., & So, K. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.019 · Cited by 74 · see citing works
Influence of exercise on mood in postmenopausal women
Gutiérrez, C. V., Torres‐Luque, G., Medina, G. M. Á., del Castillo, M. J. A., Guisado-Requena, I. M., Barrilao, R. G., & Rodrigo, J. R. (2012) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2011.03972.x · Cited by 55 · see citing works
Responses of serum neurotrophic factors to exercise in pregnant and postpartum women
Vega, S. R., Kleinert, J., Sulprizio, M., Hollmann, W., Bloch, W., & Strüder, H. K. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.012 · Cited by 51 · see citing works
Sharma, K., Mehra, R. D., Dhar, P., & Vij, U. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.027 · Cited by 40 · see citing works
Running exercise effects on spatial and avoidance tasks in ovariectomized rats
Ben, J., Soares, F. M. S., Scherer, E. B. S., Cechetti, F., Netto, C. A., & Wyse, Â. T. D. S. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.07.003 · Cited by 36 · see citing works
Tierney, M. C., Moineddin, R., Morra, A., Manson, J. A., & Blake, J. M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101188 · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416 · see citing works
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
Physical exercise in the prevention and treatment of Alzheimer's disease
la Rosa, A. D., González, G. O., Arc‐Chagnaud, C., Millán-Domingo, F., Salvador‐Pascual, A., García-Lucerga, C., Blasco-Lafarga, C., García-Domínguez, E., Carretero, A., Correas, Á. G., et al. (2020) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.01.004 · Cited by 617 · see citing works
Self-citationEl Hayek, L., Khalifeh, M., Zibara, V., Abi Assaad, R., Emmanuel, N., Karnib, N., El-Ghandour, R., Nasrallah, P., Bilen, M., Ibrahim, P., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1661-18.2019 · Cited by 539 · see citing works
Exercise Attenuates the Major Hallmarks of Aging
Garatachea, N., Pareja-Galeano, H., Sanchis-Gomar, F., Santos-Lozano, A., Fiuza-Luces, C., Morán, M., Emanuele, E., Joyner, M. J., & Lucia, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1623 · Cited by 413 · see citing works
Self-citationNeuroinflammation in the normal aging hippocampus
Barrientos, R. M., Kitt, M. M., Watkins, L. R., & Maier, S. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.007 · Cited by 315 · see citing works
Brain-Derived Neurotrophic Factor in Alzheimer’s Disease: Risk, Mechanisms, and Therapy
Song, J., Yu, J., & Tan, L. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8958-4 · Cited by 237 · see citing works
Tapia‐Rojas, C., Aránguiz, F. C., Varela‐Nallar, L., & Inestrosa, N. C. (2015) · Brain Pathology · doi:10.1111/bpa.12255 · Cited by 168 · see citing works
What is hormesis and its relevance to healthy aging and longevity?
Calabrese, E. J., Dhawan, G., Kapoor, R., Iavicoli, I., & Calabrese, V. (2015) · Biogerontology · doi:10.1007/s10522-015-9601-0 · Cited by 165 · see citing works
Physical Activity and Alzheimer Disease: A Protective Association
Santos-Lozano, A., Pareja-Galeano, H., Sanchis-Gomar, F., Quindós-Rubial, M., Fiuza-Luces, C., Cristi-Montero, C., Emanuele, E., Garatachea, N., & Lucia, A. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.04.024 · Cited by 164 · see citing works
Self-citationla Rosa, A. D., Solana, E., Corpas, R., David Bartrés-faz, A., Pallàs, M., Viña, J., Sanfeliu, C., & Gómez‐Cabrera, M. C. (2019) · Scientific Reports · doi:10.1038/s41598-019-40040-8 · Cited by 161 · see citing works
Self-citationGarcía‐Mesa, Y., Colié, S., Corpas, R., Cristòfol, R. M., Comellas, F., Nebreda, Á. R., Giménez‐Llort, L., & Sanfeliu, C. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv005 · Cited by 124 · see citing works
Self-citationKamel, A. S. E. D., Abdelkader, N. F., El‐Rahman, S. S. A., Emara, M., Zaki, H. F., & Khattab, M. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0966-3 · Cited by 118 · see citing works
Slevin, M., Matou, S., Zeinolabediny, Y., Corpas, R., Weston, R., Liu, D., Boras, E., Di Napoli, M., Petcu, E., Sarroca, S., et al. (2015) · Scientific Reports · doi:10.1038/srep13281 · Cited by 115 · see citing works
Self-citationExercise as a Polypill for Chronic Diseases
Pareja-Galeano, H., Garatachea, N., & Lucía, A. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.019 · Cited by 111 · see citing works
Self-citationRevilla, S., Ursulet, S., Álvarez‐López, M. J., Castro, M., Perpiñá, U., García‐Mesa, Y., Bortolozzi, A. A., Giménez‐Llort, L., Kaliman, P., Cristòfol, R. M., et al. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12312 · Cited by 109 · see citing works
Self-citationBernardo, T. C., Marques‐Aleixo, I., Beleza, J., Oliveira, P. J., Ascensão, A., & Magalhães, J. (2016) · Brain Pathology · doi:10.1111/bpa.12403 · Cited by 108 · see citing works
Exercise Regulation of Cognitive Function and Neuroplasticity in the Healthy and Diseased Brain
Hamilton, G. F., & Rhodes, J. S. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.004 · Cited by 83 · see citing works
The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s disease mouse model
Do, K., Laing, B. T., Landry, T., Bunner, W. P., Mersaud, N., Matsubara, T., Li, P.-X., Yuan, Y., Lu, Q., & Hu, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190205 · Cited by 78 · see citing works
An endothelial link between the benefits of physical exercise in dementia
Trigiani, L. J., & Hamel, É. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17714655 · Cited by 66 · see citing works
Belviranlı, M., & Okudan, N. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.030 · Cited by 60 · see citing works
Kim, B. Y., Lee, S. H., Graham, P. L., Angelucci, F., Lucía, A., Pareja-Galeano, H., Leyhe, T., Turana, Y., Lee, I. R., Yoon, J. H., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0192-9 · Cited by 56 · see citing works
Self-citationVeronese, N., Solmi, M., Basso, C., Smith, L., & Soysal, P. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4962 · Cited by 41 · see citing works
Yang, G., Song, Y., Zhou, X., Deng, Y., Liu, T., Weng, G., Yu, D., & Pan, S. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3531 · Cited by 39 · see citing works
Exercise Attenuates High-Fat Diet–induced Disease Progression in 3xTg-AD Mice
Kim, D., Cho, J., Lee, I., Jin, Y., & Kang, H. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001166 · Cited by 37 · see citing works
Ryu, J.-S., Kang, H., & Lee, J. K. (2020) · Brain Sciences · doi:10.3390/brainsci10110793 · Cited by 37 · see citing works
Yin, Z., Li, Y., Bao, Q.-N., Zhang, X., Xia, M., Zhong, W., Wu, K., Yao, J., Chen, Z., Sun, M., et al. (2023) · International Journal of Mental Health Nursing · doi:10.1111/inm.13254 · Cited by 36 · see citing works
Estrogen-dependent hippocampal wiring as a risk factor for age-related dementia in women
Torromino, G., Maggi, A. C., & Leonibus, E. D. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101895 · Cited by 34 · see citing works
Li, B., Mao, Q., Zhao, N., Xia, J., Zhao, Y., & Xu, B. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113502 · Cited by 32 · see citing works
Rashidy‐Pour, A., Bavarsad, K., Miladi‐Gorji, H., Seraj, Z., & Vafaei, A. A. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172819 · Cited by 30 · see citing works
Holland, C., Dravecz, N., Owens, L., Benedetto, A., Dias, I. H. K., Gow, A. J., & Broughton, S. J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102461 · Cited by 29 · see citing works
Shepherd, A. L., Zhang, T. D., Zeleznikow-Johnston, A., Hannan, A. J., & Burrows, E. L. (2018) · Brain Plasticity · doi:10.3233/bpl-180076 · Cited by 27 · see citing works
Zhang, S., Gu, B., Zhen, K., Du, L., Lv, Y., & Yu, L. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105538 · Cited by 25 · see citing works
The Positive Effects of Viewing Gardens for Persons with Dementia
Goto, S., Shen, X., Sun, M., Hamano, Y., & Herrup, K. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170510 · Cited by 27 · see citing works
Lanni, I., Chiacchierini, G., Papagno, C., Santangelo, V., & Campolongo, P. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105831 · Cited by 22 · see citing works
Li, X., Zhuang, Y., Wu, L., Xie, M., Gu, H., Wang, B., & Tang, X. (2019) · Neuropsychobiology · doi:10.1159/000501294 · Cited by 22 · see citing works
Sabouri, M., Kordi, M. R., Shabkhiz, F., Taghibeikzadehbadr, P., & Geramian, Z. S. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111056 · Cited by 22 · see citing works
Loss of association between plasma irisin levels and cognition in Alzheimer’s disease
Kim, K. Y., Kwak, S., Ha, J., Oh, D. J., Kim, M., Cho, S. Y., Kim, H., Lee, J., & Kim, E. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105624 · Cited by 22 · see citing works
Novel approaches to increase synaptic resilience as potential treatments for Alzheimer’s disease
Pham, A. Q., & Dore, K. (2023) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2022.03.032 · Cited by 21 · see citing works
Rai, S. P., Krohn, M., & Pahnke, J. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200161 · Cited by 18 · see citing works
The emerging role of exercise in Alzheimer’s disease: Focus on mitochondrial function
Feng, L., Li, B., Yong, S. S., Xu, W., & Tian, Z. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102486 · Cited by 17 · see citing works
Brain-Derived Neurotrophic Factor and Delayed Verbal Recall in Crack/Cocaine Dependents
Viola, T. W., Tractenberg, S. G., Kluwe‐Schiavon, B., Levandowski, M. L., Sanvicente‐Vieira, B., Wearick‐Silva, L. E., de Azeredo, L. A., Teixeira, A. L., & Grassi‐Oliveira, R. (2015) · European Addiction Research · doi:10.1159/000430436 · Cited by 17 · see citing works
Khoury, R. E., Saad, J., Jabre, V., Ghayad, L. M., Khalifeh, M., Houbeika, R. Y., Ahmad, P. E., Mezher, A., Masri, D. E., Haddad, Z. L., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14705 · Cited by 15 · see citing works
Martín-Rodríguez, A., Dalamitros, A. A., Madrigal-Cerezo, R., Sánchez-Conde, P., Clemente‐Suárez, V. J., & Tornero-Aguilera, J. F. (2025) · Geriatrics · doi:10.3390/geriatrics10060143 · Cited by 16 · see citing works
Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases
You, H. J., Park, J. H., Pareja-Galeano, H., Lucía, A., & Shin, J. I. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8407-9 · Cited by 13 · see citing works
Self-citationRauf, S., Soesatyo, M. H. N. E., Agustiningsih, D., & Partadiredja, G. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112481 · Cited by 12 · see citing works
Angelopoulou, E., Bougea, A. M., Hatzimanolis, A., Scarmeas, N., & Papageorgiou, S. G. (2024) · Cells · doi:10.3390/cells13131164 · Cited by 14 · see citing works
Voluntary exercise ameliorates the good limb training effect in a mouse model of stroke
Nemchek, V., Haan, E. M., Mavros, R., Macuiba, A., & Kerr, A. L. (2021) · Experimental Brain Research · doi:10.1007/s00221-020-05994-6 · Cited by 11 · see citing works
Li, Y., Zhao, Z., Cai, J., Gu, B., Lv, Y., & Zhao, L. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00212 · Cited by 11 · see citing works
Mediation Analyses of the Role of Apathy on Motoric Cognitive Outcomes
Ceïde, M. E., Eguchi, D., Ayers, E. I., Lounsbury, D. W., & Verghese, J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19127376 · Cited by 10 · see citing works
Chui, D. (2014) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2014/10301.5141 · Cited by 9 · see citing works
Mudalige, D. M., Guan, D. X., Ballard, C. G., Creese, B., Corbett, A., Pickering, E., Roach, P., Smith, E. E., & Ismail, Z. (2024) · International Review of Psychiatry · doi:10.1080/09540261.2024.2360561 · Cited by 7 · see citing works
The Potential of Gonadal Hormone Signalling Pathways as Therapeutics for Dementia
Du, X., & Hill, R. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0813-9 · Cited by 6 · see citing works
Exercise, spinogenesis and cognitive functions
Zhang, L., & So, K. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.07.005 · Cited by 6 · see citing works
Huang, Y., Wang, Y., Gao, Y., Liu, Q., Ye, F.-F., Guo, B., Wu, Y.-C., & Xue, L. (2020) · Nano LIFE · doi:10.1142/s1793984420400073 · Cited by 6 · see citing works
Gender Differences in the Effects of Exercise Interventions on Alzheimer’s Disease
Dong, Y., Shi, L., Ma, Y., Liu, Y., Sun, Y., & Jin, Q. (2025) · Brain Sciences · doi:10.3390/brainsci15080812 · Cited by 5 · see citing works
Mohseni, I., Peeri, M., & Azarbayjani, M. A. (2020) · Journal of Medicinal Plants · doi:10.29252/jmp.1.73.119 · Cited by 4 · see citing works
Sabaghi, A., Heirani, A., Kiani, A., Yousofvand, N., & Sabaghi, S. (2020) · Neurochemical Journal · doi:10.1134/s1819712420020105 · Cited by 3 · see citing works
Bahabry, R., Jago, S. S., Hauser, R. M., Harmon, J., Sheppard, L. D., Oyassan, B., & Lubin, F. D. (2024) · Epilepsy & Behavior Reports · doi:10.1016/j.ebr.2024.100735 · Cited by 3 · see citing works
Li, L., & Wang, K. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1698135 · Cited by 2 · see citing works
Shoghi, E., Safari, T., Parsi-Moud, A., Mirzaei, I., Rad, N. S., & Chahkandi, M. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112442 · Cited by 1 · see citing works
Early Metabolic Differences in Alzheimer’s Disease Mouse Model and Exercise Intervention Treatment
Do, K. (2017) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
PENURUNNYA KECEMASAN TIKUS OVARIEKTOMI SETELAH LATIHAN INVERVAL DENGAN INTENSITAS TINGGI
Rauf, S. (2019) · Jurnal Kesehatan Terpadu (Integrated Health Journal) · doi:10.32695/jkt.v2i9.15
Protocolos De Treinamento Físico Em Modelos Experimentais Usados Na Pesquisa Em Educação Física
Costa‐Santos, N. D., dos Santos, A., Nascimento‐Carvalho, B., Izaías, J. E., Batista, T. F. R., Caperuto, É. C., Scapini, K. B., Bernardes, N., & Sanches, Í. C. (2021) · Colloquium health and education · doi:10.37497/colloquium.v1i2.16
Souri, M., Rvasi, A., Birar, A., Heydari, F., Yousefzadeh, H., & Hosseini, A. (2022) · مجله علمی پزشکی جندی شاپور · doi:10.32598/jsmj.21.3.2548
Xu, W., Zhang, G. L., Bai, X., Zhang, S., Zhao, M., Liu, H., Duan, W., Bai, J., Chen, Y., Luo, Y., et al. (2026) · Journal of Clinical Nursing · doi:10.1111/jocn.70344
Lippi, S. L. P., McAlpine, Z. I., & Halliburton, A. B. (2026) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad3030044
- Authors
- García-Mesa, Y., Pareja-Galeano, H., Bonet-Costa, V., Revilla, S., Gómez-Cabrera, M. C., Gambini, J., Giménez-Llort, L., Cristòfol, R., Viña, J., & Sanfeliu, C.
- Affiliations
- Universitat de València (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Viña, José
- Sanfeliu, Coral
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 45
- Pages
- 154-166
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2027048110
- Cited by
- 68
- References
- 47
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 9 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 8 · 2014: 4 · 2012: 1
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Fundació la Marató de TV3
- Universitat de Barcelona
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- physical activity, neuroprotection, ovariectomy, 3xTg-AD mice, Alzheimer's disease, brain-derived neurotrophic factor, CREB, postmenopausal women, voluntary running, cognitive impairment, memory loss, behavioral and psychological symptoms of dementia, hippocampus, estrogen deficiency, frailty, apathy
- MeSH terms
- Alzheimer Disease, Animals, Cognition, Disease Models, Animal, Female, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Ovariectomy, Physical Conditioning, Animal, Signal Transduction, Amyloid beta-Protein Precursor, tau Proteins, Neuroprotective Agents, Brain-Derived Neurotrophic Factor, Cytoprotection, Mice, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
