Cited by 108Mitochondrial Function and PathologyAlzheimer's disease research and treatmentsPhysical Activity and Health

Physical Exercise and Brain Mitochondrial Fitness: The Possible Role Against A lzheimer's Disease

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Bernardo, T.C., Marques‐Aleixo, I., Beleza, J., Oliveira, P.J., Ascensão, A., Magalhães, J.·2016·Brain Pathology

Abstract

Exercise is one of the most effective strategies to maintain a healthy body and mind, with particular beneficial effects of exercise on promoting brain plasticity, increasing cognition and reducing the risk of cognitive decline and dementia in later life. Moreover, the beneficial effects resulting from increased physical activity occur at different levels of cellular organization, mitochondria being preferential target organelles. The relevance of this review article relies on the need to integrate the current knowledge of proposed mechanisms, focus mitochondria, to explain the protective effects of exercise that might underlie neuroplasticity and seeks to synthesize these data in the context of exploring exercise as a feasible intervention to delay cognitive impairment associated with neurodegenerative conditions, particularly Alzheimer disease.

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  • Given the similarity in mitochondrial dysfunction observed in obesity, type 2 diabetes, and AD, it is reasonable to hypothesize that lifestyle interventions, if implemented in midlife or earlier, may protect against the mitochondrial dysfunction evident in AD.

    “Given the similarity in mitochondrial dysfunction observed in obesity, type 2 diabetes, and AD [184,185,186,187], it is reasonable to hypothesize that these lifestyle interventions, if implemented in midlife or earlier, may protect against the mitochondrial dysfunction evident in AD.”

    From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [184]

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  1. [4]4. Ahlskog JE, Geda YE, Graff‐Radford NR, Petersen RC (eds) (2011) Physical Exercise as a Preventive or Disease‐Modifying Treatment of Dementia and Brain Aging. Mayo Clinic Proceedings. Elsevier: New York. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. [102]102. Heyn P, Abreu BC, Ottenbacher KJ (2004) The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta‐analysis. Arch Phys Med Rehabil 85:1694–1704. [DOI] [PubMed] [Google Scholar]
  3. [157]157. Pareja‐Galeano H, Brioche T, Sanchis‐Gomar F, Escriva C, Dromant M, Gomez‐Cabrera MC et al (2012) Effects of physical exercise on cognitive alterations and oxidative stress in an APP/PSN1 transgenic model of Alzheimer's disease. Rev Esp Geriatr Gerontol 47:198–204. [DOI] [PubMed] [Google Scholar]
  4. [165]165. Petersen CAH, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, Alafuzoff I et al (2008) The amyloid β‐peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci 105:13145–13150. [DOI] [PMC free article] [PubMed] [Google Scholar]

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Authors
Bernardo, T. C., Marques‐Aleixo, I., Beleza, J., Oliveira, P. J., Ascensão, A., & Magalhães, J.
Affiliations
  • Universidade do Porto (PT)
  • Biocant – Associação de Transferência de Tecnologia (PT)
Venue
Brain Pathology
Publisher
Wiley
Published
2016-09
Volume
26
Issue
5
Pages
648-663
ISSN
  • 1015-6305 (ISSN-L)
  • 1750-3639
OpenAlex
W2471606802
Cited by
108
References
248
Citations by year
2026: 9 · 2025: 13 · 2024: 13 · 2023: 9 · 2022: 14 · 2021: 11 · 2020: 11 · 2019: 17 · 2018: 5 · 2017: 3 · 2016: 3
FWCI
0.83
Type
journal article
Language
en
Open access
Locations
  • Brain Pathology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Portuguese Foundation for Science and Technology (FCT) (POCI-01-0145-FEDER-016690 - PTDC/DTP-DES/7087/2014)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
physical activity, mitochondrial fitness, Alzheimer's disease, neuroprotection, neuroplasticity, cognitive decline, dementia, neurodegeneration, mitochondrial function, exercise intervention
MeSH terms
Alzheimer Disease, Animals, Brain, Exercise Therapy, Humans, Mitochondria, Exercise, tau Proteins, Mitochondrial Diseases

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