Cited by 316Regulation of Appetite and ObesityVagus Nerve Stimulation ResearchGastrointestinal motility and disorders

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The vagus nerve, food intake and obesity

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Berthoud, Hans-Rudolf·2008·Regulatory Peptides

DOI 10.1016/j.regpep.2007.08.024PMC PMC2597723

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Abstract

Food interacts with sensors all along the alimentary canal to provide the brain with information regarding its composition, energy content, and beneficial effect. Vagal afferents innervating the gastrointestinal tract, pancreas, and liver provide a rapid and discrete account of digestible food in the alimentary canal, as well as circulating and stored fuels, while vagal efferents, together with the sympathetic nervous system and hormonal mechanisms, codetermine the rate of nutrient absorption, partitioning, storage, and mobilization. Although vagal sensory mechanisms play a crucial role in the neural mechanism of satiation, there is little evidence suggesting a significant role in long-term energy homeostasis. However, increasing recognition of vagal involvement in the putative mechanisms making bariatric surgeries the most effective treatment for obesity should greatly stimulate future research to uncover the many details regarding the specific transduction mechanisms in the periphery and the inter- and intra-neuronal signaling cascades disseminating vagal information across the neuraxis.

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The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders
Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189
“They influence the control of food intake and regulation of satiety, gastric emptying and energy balance (39) by transmitting signals arising from the upper gut to the nucleus of the solitary tract in the brain (40).”
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The microbiota–gut–brain axis in obesity
Torres‐Fuentes, C., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(17)30147-4 · Cited by 623
Genetic identification of vagal sensory neurons that control feeding
Bai, L., Mesgarzadeh, S., Ramesh, K. S., Huey, E. L., Liu, Y., Gray, L. A., Aitken, T. J., Chen, Y., Beutler, L. R., Ahn, J. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.031 · Cited by 494
Hindbrain Neurons as an Essential Hub in the Neuroanatomically Distributed Control of Energy Balance
Grill, H. J., & Hayes, M. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.015 · Cited by 501

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Authors: Berthoud, H.-R.
Affiliations: Pennington Biomedical Research Center (US)
Corresponding author: Berthoud, Hans-Rudolf
ORCID: Berthoud, Hans-Rudolf
Venue: Regulatory Peptides
Publisher: Elsevier BV
Published: 2008-08
Volume: 149
Issue: 1-3
Pages: 15-25
ISSN: 0167-0115 (ISSN-L)
DOI: 10.1016/j.regpep.2007.08.024
PMC: PMC2597723
OpenAlex: W2110310483
Cited by: 316
References: 182
Citations by year: 2026: 13 · 2025: 20 · 2024: 7 · 2023: 15 · 2022: 9 · 2021: 18 · 2020: 24 · 2019: 24 · 2018: 28 · 2017: 23 · 2016: 16 · 2015: 21 · 2014: 19 · 2013: 18 · 2012: 17
FWCI: 1.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Regulatory Peptides (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071082, R01DK047348)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: vagus nerve, vagal afferents, vagal efferents, dietary intake, obesity, satiation, energy homeostasis, nutrient absorption, nutrient partitioning, bariatric surgery
MeSH terms: Animals, Eating, Humans, Models, Biological, Obesity, Vagus Nerve

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The vagus nerve, food intake and obesity

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