Psychiatric symptoms in boys with fragile X syndrome: a comparison with nonsyndromic autism spectrum disorder
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In the present study, we examined the profile of psychiatric symptoms in boys with fragile X syndrome (FXS) using a parent report instrument. In addition, by comparing boys with FXS to boys with nonsyndromic autism spectrum disorder (ASD) utilizing multiple matching strategies, we examined between-group differences in the types of psychiatric symptoms observed and in the strength of their concurrent associations. Across all matching strategies, symptoms of manic/hyperactive behaviors and general anxiety were more frequently reported for boys with FXS than for boys with nonsyndromic ASD. Results also indicated a positive association between social avoidance and general anxiety in FXS that was stronger than that observed in nonsyndromic ASD across all matching strategies. Theoretical and treatment implications are discussed.
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The only study to date that has examined the therapeutic potential of intranasal OT specifically in the Fragile X population found a correlation between improvements in a measure of social anxiety and decreased serum cortisol levels.
“Moreover, the only study to date that has examined the therapeutic potential of intranasal OT specifically in the Fragile X population (Hall et al., 2012), found a correlation between improvements in a measure of social anxiety (a syndromic symptom that is seen more frequently in Fragile X than ASD (Thurman et al., 2014)) and decreased serum cortisol levels (Hall et al., 2012).”
From Parallel social information processing circuits are differentially impacted in autism (2020) · cites this paper as Thurman et al., 2014
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- Authors
- Thurman, A. J., McDuffie, A., Hagerman, R., & Abbeduto, L.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Thurman, Angela John
- Venue
- Research in Developmental Disabilities
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 35
- Issue
- 5
- Pages
- 1072-1086
- ISSN
- 0891-4222 (ISSN-L)
- PMC
- PMC4009990
- OpenAlex
- W2109269836
- Cited by
- 70
- References
- 69
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 5 · 2015: 10 · 2014: 7
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Research in Developmental Disabilities (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Child Health and Human Development (R01 HD054764)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Keywords
- fragile X syndrome, autism spectrum disorder, psychiatric symptoms, boys, general anxiety, social avoidance, parent report, matched comparison, comorbidities
- MeSH terms
- Anxiety, Attention Deficit Disorder with Hyperactivity, Child, Child Development Disorders, Pervasive, Child, Preschool, Compulsive Behavior, Fragile X Syndrome, Humans, Male, Obsessive Behavior, Social Behavior
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