Uncinate fasciculus abnormalities in recent onset schizophrenia and affective psychosis: A diffusion tensor imaging study
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Two of the most frequently investigated regions in diffusion tensor imaging studies in chronic schizophrenia are the uncinate fasciculus (UF) and cingulum bundle (CB). The purpose of the present study was to determine whether UF and CB white matter integrity were altered at the early stage of illness and specific to schizophrenia. Fifteen schizophrenia subjects and 15 affective psychosis within 4 years of first hospitalization (12 patients with schizophrenia and 12 patients with affective psychosis during their first hospitalization), and 15 psychiatrically healthy controls underwent line-scan diffusion tensor imaging. Fractional anisotropy (FA) and mean diffusivity (D(m)) were used to quantify water diffusion, and cross-sectional area was defined with a directional threshold method. Bilaterally reduced FA, but not D(m), was present in the UF of schizophrenia compared with healthy controls. Affective psychosis was intermediate between schizophrenia subjects and healthy controls, but not significantly different from either. For CB, there was no significant group difference for FA or D(m). These findings suggest that UF, but not CB, white matter integrity is altered at the early stage of illness in schizophrenia although it may not be specific to schizophrenia. The CB abnormalities reported in chronic schizophrenia may develop during the later course of the disease.
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Patients with schizophrenia exhibit structural abnormalities in the cerebral white matter.
“After more than 2 decades of neuroimaging research, it is now well established that patients with schizophrenia exhibit structural abnormalities in the cerebral white matter.”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [22]
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- Authors
- Kawashima, T., Nakamura, M., Bouix, S., Kubicki, M., Salisbury, D. F., Westin, C.-F., McCarley, R. W., & Shenton, M. E.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- Shenton, Martha E.
- ORCID
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 110
- Issue
- 1-3
- Pages
- 119-126
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC2749228
- OpenAlex
- W2029054575
- Cited by
- 65
- References
- 56
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Espace ÉTS (ETS) (submittedVersion)
- Funders
- National Institutes of Health (R01 MH 50747, R01 MH 58704, K05 MH 070047, R01 MH 40799, U54 EB005149)
- Japan Foundation for Aging and Health
- U.S. Department of Veterans Affairs
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- uncinate fasciculus, cingulum
- MeSH terms
- Adult, Affective Disorders, Psychotic, Analysis of Variance, Brain Mapping, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Schizophrenia, Chi-Square Distribution, Anisotropy, Perforant Pathway, Diffusion Magnetic Resonance Imaging, Young Adult
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