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Cited by 210Schizophrenia research and treatmentMental Health and PsychiatryNeurotransmitter Receptor Influence on Behavior

Endophenotypes in schizophrenia: A selective review

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Allen, Allyssa J., Griss, Mélina E., Folley, Bradley S., Hawkins, Keith A., Pearlson, Godfrey D.·2009·Schizophrenia Research
DOI 10.1016/j.schres.2009.01.016PMC PMC2665704
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Abstract

Background Given the wealth of data in the literature on schizophrenia endophenotypes, it is useful to have one source to reference their frequency data. We reviewed the literature on disease-liability associated variants in structural and functional magnetic resonance images (MRI), sensory processing measures, neuromotor abilities, neuropsychological measures, and physical characteristics in schizophrenia patients (SCZ), their first-degree relatives (REL), and healthy controls (HC). The purpose of this review was to provide a summary of the existing data on the most extensively published endophenotypes for schizophrenia.Methods We searched PubMed and MedLine for all studies on schizophrenia endophenotypes comparing SCZ to HC and/or REL to HC groups. Percent abnormal values, generally defined as >2 SD from the mean (in the direction of abnormality) and/or associated effect sizes (Cohen's d) were calculated for each study.Results Combined, the articles reported an average 39.4% (SD=20.7%; range=2.2-100%) of abnormal values in SCZ, 28.1% (SD=16.6%; range=1.6-67.0%) abnormal values in REL, and 10.2% (SD=6.7%; range=0.0-34.6%) in HC groups.Conclusions These findings are reviewed in the context of emerging hypotheses on schizophrenia endophenotypes, as well as a discussion of clustering trends among the various intermediate phenotypes. In addition, programs for future research are discussed, as instantiated in a few recent large-scale studies on multiple endophenotypes across patients, relatives, and healthy controls.

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  • Neuromotor, neuropsychological, and physiological endophenotypes appear in attenuated form in relatives of people with psychotic disorders, suggesting similar latent biological mechanisms across the psychosis spectrum.

    “Finally, a range of neuromotor, neuropsychological, and physiological endophenotypes appear in attenuated form in relatives of individuals with psychotic disorders (Allen et al., 2009), suggesting that latent biological mechanisms are similar throughout the psychosis spectrum.”

    From Narrative identity in the psychosis spectrum: A systematic review and developmental model (2021) · cites this paper as Allen et al., 2009

    The Introduction says endophenotypes occur in some unaffected relatives, and the review covers neuromotor, neuropsychological, and physiological abnormalities. But the review examines relatives of people with schizophrenia; it does not establish the cited finding for relatives of people with psychotic disorders across the spectrum. The sentence’s final suggestion about shared mechanisms is the citing authors’ inference, not the part directly attributed to this source. (LLM, conf=0.84)

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Research works printed but not linked: 3

  1. Altman E Hedeker D Davis JM Comaty JE Jobe TH Levy DL 1990 Neuropsychological test deficits are associated with smooth pursuit eye movement impairment in affective disorders but not in schizophrenia International Journal of Clinical Neuropsychology 12 49 59
  2. Lawrie SM Whalley H Kestelman JN Abukmeil SS Byrne M Hodges A 1999b Magnetic resonance imaging of brain in people at high risk of developing schizophrenia comment Lancet 353 9146 30 33 10023948
  3. Ritsner MS 2009 Neuropsychiatric Biomarkers, Endophenotypes and Genes: Promises, Advances and Challenges Springer in press

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Authors
Allen, A. J., Griss, M. E., Folley, B. S., Hawkins, K. A., & Pearlson, G. D.
Affiliations
  • Hartford Hospital (US)
  • Yale University (US)
Corresponding author
Allen, Allyssa J.
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2009-04
Volume
109
Issue
1-3
Pages
24-37
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2009.01.016
PMC
PMC2665704
OpenAlex
W2102684787
Cited by
210
References
274
Citations by year
2026: 5 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 6 · 2017: 16 · 2016: 15 · 2015: 21 · 2014: 20 · 2013: 21 · 2012: 29
FWCI
2.53
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Korea Electrotechnology Research Institute
  • National Institute of Mental Health (MH074797, R01MH074797, R37MH043775, R01MH077945)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
schizophrenia, endophenotypes
MeSH terms
Cognition Disorders, Family, Humans, Phenotype, Schizophrenia, Schizophrenic Psychology, Statistics as Topic, Biomarkers, Cluster Analysis

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