General functioning predicts reward and punishment learning in schizophrenia
Abstract
Previous studies investigating feedback-driven reinforcement learning in patients with schizophrenia have provided mixed results. In this study, we explored the clinical predictors of reward and punishment learning using a probabilistic classification learning task. Patients with schizophrenia (n=40) performed similarly to healthy controls (n=30) on the classification learning task. However, more severe negative and general symptoms were associated with lower reward-learning performance, whereas poorer general psychosocial functioning was correlated with both lower reward- and punishment-learning performances. Multiple linear regression analyses indicated that general psychosocial functioning was the only significant predictor of reinforcement learning performance when education, antipsychotic dose, and positive, negative and general symptoms were included in the analysis. These results suggest a close relationship between reinforcement learning and general psychosocial functioning in schizophrenia.
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Reward learning may be typical in schizophrenia over longer learning trials, and in individuals with less severe symptoms.
“However, reward learning may be typical in schizophrenia over longer learning trials [410], and in individuals with less severe symptoms [414].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [414]
Cites
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
The mini international neuropsychiatric interview
Lecrubier, Y., Sheehan, D. V., Hergueta, T., & Weiller, E. (1998) · European Psychiatry · doi:10.1016/s0924-9338(99)80239-9 · Cited by 5,882 · see citing works
DSM-IV: Diagnostic and Statistical Manual of Mental Disorders
Bell, C. C. (1994) · JAMA · doi:10.1001/jama.1994.03520100096046 · Cited by 2,608 · see citing works
Chlorpromazine Equivalent Doses for the Newer Atypical Antipsychotics
Woods, S. W. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n0607 · Cited by 2,056 · see citing works
Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans
Pessiglione, M., Seymour, B., Flandin, G., Dolan, R. J., & Frith, C. D. (2006) · Nature · doi:10.1038/nature05051 · Cited by 1,584 · see citing works
Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS
Green, M. F., Kern, R. S., & Heaton, R. K. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.09.009 · Cited by 1,422 · see citing works
Dysfunction of ventral striatal reward prediction in schizophrenia
Juckel, G., Schlagenhauf, F., Koslowski, M., Wüstenberg, T., Villringer, A., Knutson, B., Wrase, J., & Heinz, A. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.051 · Cited by 578 · see citing works
Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
Murray, G. K., Corlett, P. R., Clark, L., Pessiglione, M., Blackwell, A. D., Honey, G., Jones, P. B., Bullmore, E. T., Robbins, T. W., & Fletcher, P. C. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002058 · Cited by 532 · see citing works
Reward Processing in Schizophrenia: A Deficit in the Representation of Value
Gold, J. M., Waltz, J. A., Prentice, K. J., Morris, S. E., & Heerey, E. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn068 · Cited by 521 · see citing works
From dopamine to salience to psychosis—Linking biology, pharmacology and phenomenology of psychosis
Kapur, S., Mizrahi, R., & Li, M. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.01.003 · Cited by 512 · see citing works
Bódi, N., Kéri, S., Nagy, H., Moustafa, A. A., Myers, C. E., Daw, N. D., Dibó, G., Takáts, A., Bereczki, D., & Gluck, M. A. (2009) · Brain · doi:10.1093/brain/awp094 · Cited by 356 · see citing works
Self-citationWaltz, J. A., & Gold, J. M. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.03.010 · Cited by 331 · see citing works
Waltz, J. A., Frank, M. J., Robinson, B. M., & Gold, J. M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.042 · Cited by 326 · see citing works
Juckel, G., Schlagenhauf, F., Koslowski, M., Filonov, D., Wüstenberg, T., Villringer, A., Knutson, B., Kienast, T., Gallinat, J., Wrase, J., et al. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0405-4 · Cited by 323 · see citing works
Human Midbrain Sensitivity to Cognitive Feedback and Uncertainty During Classification Learning
Aron, A. R., Daphna Shohamy, A., Clark, J. A., Myers, C. E., Gluck, M. A., & Poldrack, R. A. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01209.2003 · Cited by 265 · see citing works
Self-citationNeural correlates of reward processing in schizophrenia — Relationship to apathy and depression
Simon, J. J., Biller, A., Walther, S., Roesch-Ely, D., Stippich, C., Weisbrod, M., & Kaiser, S. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.11.007 · Cited by 222 · see citing works
Transient Overexpression of Striatal D2 Receptors Impairs Operant Motivation and Interval Timing
Drew, M. R., Simpson, E., Kellendonk, C., Herzberg, W., Lipatova, O., Fairhurst, S. P., Kandel, E., Malapani, C., & Balsam, P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1736-07.2007 · Cited by 220 · see citing works
Reward feedback alterations in unmedicated schizophrenia patients: Relevance for delusions
Schlagenhauf, F., Sterzer, P., Schmack, K., Ballmaier, M., Rapp, M., Wrase, J., Juckel, G., Gallinat, J., & Heinz, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.016 · Cited by 195 · see citing works
Waltz, J. A., Schweitzer, J. B., Gold, J. M., Kurup, P. K., Ross, T. J., Jo Salmeron, B., Rose, E. J., McClure, S. M., & Stein, E. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.214 · Cited by 186 · see citing works
Reinforcement and Reversal Learning in First-Episode Psychosis
Murray, G. K., Cheng, F., Clark, L., Barnett, J. H., Blackwell, A. D., Fletcher, P. C., Robbins, T. W., Bullmore, E. T., & Jones, P. B. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn078 · Cited by 159 · see citing works
Turning it Upside Down: Areas of Preserved Cognitive Function in Schizophrenia
Gold, J. M., Hahn, B., Strauss, G. P., & Waltz, J. A. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9098-x · Cited by 127 · see citing works
Beninger, R. J., Wasserman, J., Zanibbi, K., Charbonneau, D., Mangels, J. A., & Beninger, B. V. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00315-8 · Cited by 121 · see citing works
Weickert, T. W., Terrazas, A., Bigelow, L. B., Malley, J. D., Hyde, T. M., Egan, M. F., Weinberger, D. R., & Goldberg, T. E. (2002) · Learning & Memory · doi:10.1101/lm.49102 · Cited by 110 · see citing works
Koch, K., Schachtzabel, C., Wagner, G., Schikora, J., Schultz, C., Reichenbach, J. R., Sauer, H., & Schlösser, R. G. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.031 · Cited by 101 · see citing works
Dickerson, F., Tenhula, W. N., & Green-Paden, L. D. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.08.026 · Cited by 95 · see citing works
Cognitive deficits in patients with schizophrenia: effects and treatment.
Keefe, R. S. E. (2007) · PubMed · Cited by 90 · see citing works
Silverstein, S. M., Spaulding, W. D., Menditto, A. A., Savitz, A. J., Liberman, R. P., Berten, S., & Starobin, H. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm150 · Cited by 89 · see citing works
Impaired implicit learning in schizophrenia.
Horan, W. P., Green, M. F., Knowlton, B. J., Wynn, J. K., Mintz, J., & Nuechterlein, K. H. (2008) · Neuropsychology · doi:10.1037/a0012602 · Cited by 79 · see citing works
Neural Correlates of Probabilistic Category Learning in Patients with Schizophrenia
Weickert, T. W., Goldberg, T. E., Callicott, J. H., Chen, Q., Apud, J. A., Das, S., Zoltick, B. J., Egan, M. F., Meeter, M., Myers, C. E., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4341-08.2009 · Cited by 78 · see citing works
Self-citationSchizophrenics know more than they can tell: probabilistic classification learning in schizophrenia
Kéri, S., Kelemen, O., Szekeres, G., Bagóczky, N., Erdélyi, R., Antal, A., Benedek, G., & Janka, Z. (2000) · Psychological Medicine · doi:10.1017/s0033291799001403 · Cited by 78 · see citing works
Self-citationFoerde, K., Poldrack, R. A., Knowlton, B. J., Sabb, F. W., Bookheimer, S. Y., Bilder, R. M., Guthrie, D., Granholm, E., Nuechterlein, K. H., Marder, S. R., et al. (2008) · Neuropsychology · doi:10.1037/0894-4105.22.1.100 · Cited by 67 · see citing works
Dissociation between medial temporal lobe and basal ganglia memory systems in schizophrenia
Kéri, S., Nagy, O., Kelemen, O., Myers, C. E., & Gluck, M. A. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.03.024 · Cited by 67 · see citing works
Self-citationLaviolette, S. R., Lauzon, N. M., Bishop, S. F., Sun, N., & Tan, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1371-08.2008 · Cited by 58 · see citing works
Yip, S. W., Sacco, K. A., George, T. P., & Potenza, M. N. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.01.012 · Cited by 57 · see citing works
Impairment of probabilistic reward-based learning in schizophrenia.
Weiler, J. A., Bellebaum, C., Brüne, M., Juckel, G., & Daum, I. (2009) · Neuropsychology · doi:10.1037/a0016166 · Cited by 55 · see citing works
Associative learning in deficit and nondeficit schizophrenia
Farkas, M., Polgár, P., Kelemen, O., Réthelyi, J., Bitter, I., Myers, C. E., Gluck, M. A., & Kéri, S. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3282f2dff6 · Cited by 39 · see citing works
Self-citationPolgár, P., Farkas, M., Nagy, O., Kelemen, O., Réthelyi, J., Bitter, I., Myers, C. E., Gluck, M. A., & Kéri, S. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.06.027 · Cited by 38 · see citing works
Self-citationLearning and Generalization in Schizophrenia: Effects of Disease and Antipsychotic Drug Treatment
Daphna Shohamy, A., Mihalakos, P., Chin, R., Thomas, B. P., Wagner, A. D., & Tamminga, C. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.025 · Cited by 37 · see citing works
Effects of Risperidone on Procedural Learning in Antipsychotic-Naive First-Episode Schizophrenia
Harris, M. S. H., Wiseman, C. L., Reilly, J. L., Keshavan, M. S., & Sweeney, J. A. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.79 · Cited by 27 · see citing works
Procedural Memory Predicts Social Skills in Persons With Schizophrenia
Kawakubo, Y., Rogers, M. A., & Kasai, K. (2006) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000231429.40421.84 · Cited by 8 · see citing works
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Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Barch, D. M., Pagliaccio, D., & Luking, K. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_376 · Cited by 218 · see citing works
Striatal dopamine, reward, and decision making in schizophrenia
Deserno, L., Schlagenhauf, F., & Heinz, A. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.1/ldeserno · Cited by 58 · see citing works
Computational approaches to schizophrenia: A perspective on negative symptoms
Deserno, L., Heinz, A., & Schlagenhauf, F. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2016.10.004 · Cited by 31 · see citing works
- Authors
- Somlai, Z., Moustafa, A. A., Kéri, S., Myers, C. E., & Gluck, M. A.
- Affiliations
- Semmelweis University (HU)
- Rutgers, The State University of New Jersey (US)
- University of Szeged (HU)
- Corresponding author
- Moustafa, Ahmed A.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 127
- Issue
- 1-3
- Pages
- 131-136
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2151292929
- Cited by
- 45
- References
- 41
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Semmelweis University Repository (Semmelweis University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, reinforcement learning
- MeSH terms
- Adult, Analysis of Variance, Female, Humans, Learning Disabilities, Male, Middle Aged, Neuropsychological Tests, Punishment, Reward, Schizophrenia, Schizophrenic Psychology, Young Adult
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