Striatal dopamine, reward, and decision making in schizophrenia
Open accessAbstract
Elevated striatal dopamine function is one of the best-established findings in schizophrenia. In this review, we discuss causes and consequences of this striata! dopamine alteration. We first summarize earlier findings regarding striatal reward processing and anticipation using functional neuroimaging. Secondly, we present a series of recent studies that are exemplary for a particular research approach: a combination of theory-driven reinforcement learning and decision-making tasks in combination with computational modeling and functional neuroimaging. We discuss why this approach represents a promising tool to understand underlying mechanisms of symptom dimensions by dissecting the contribution of multiple behavioral control systems working in parallel. We also discuss how it can advance our understanding of the neurobiological implementation of such functions. Thirdly, we review evidence regarding the topography of dopamine dysfunction within the striatum. Finally, we present conclusions and outline important aspects to be considered in future studies.
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Nucleus accumbens dysfunction has been heavily implicated in schizophrenia.
“In ventral striatum, nucleus accumbens (NAc) dysfunction has been heavily implicated in schizophrenia [19, 20].”
From Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility (2024) · cites this paper as [20]
The Reward anticipation section reports replicated reductions in ventral striatal activation in unmedicated and medication-naive patients with schizophrenia, supporting the broader ventral-striatum claim. It does not specifically identify nucleus accumbens dysfunction in those patients, and it notes that the reduction was not observed in patients taking second-generation antipsychotics. Page numbers are unavailable in our copy. (LLM, conf=0.82)
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Flagged first, then by citations
Research works printed but not linked: 2
- [6]Howes OD. Kambeitz J. Kim E. et al The nature of dopamine dysfunction in schizophrenia and what this means for treatment. Arch Gen Psychiatry 2012 69 8 776 786 22474070 PMC3730746
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- Authors
- Deserno, L., Schlagenhauf, F., & Heinz, A.
- Affiliations
- Max Planck Institute for Human Cognitive and Brain Sciences (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Deserno, Lorenz
- Venue
- Dialogues in Clinical Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2016-03-31
- Volume
- 18
- Issue
- 1
- Pages
- 77-89
- ISSN
- 1294-8322 (ISSN-L)
- 1958-5969
- PMC
- PMC4826774
- OpenAlex
- W2340310467
- Cited by
- 58
- References
- 120
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 1 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 2
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- schizophrenia, striatal dopamine, reward processing, reward anticipation, decision-making, reinforcement learning, computational modeling, functional neuroimaging
- MeSH terms
- Animals, Corpus Striatum, Decision Making, Dopamine, Humans, Nerve Net, Reward, Schizophrenia, Functional Neuroimaging
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