Association between cannabis use, psychosis, and schizotypal personality disorder: findings from the National Epidemiologic Survey on Alcohol and Related Conditions
Open accessAbstract
Background Studies to date showing an association between cannabis use and schizophrenia-spectrum disorders are of relatively small sample sizes with limitations in generalizability. The present study addresses this gap by examining the relationship between cannabis use and psychotic-like symptoms in a large representative community sample.Method Data were derived from the 2004-2005 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, Wave 2), a large, nationally representative sample of 34,653 adults from the United States population. We evaluated the association between lifetime cannabis use, psychosis, and schizotypal personality features.Results The prevalence of psychosis and schizotypal personality disorder increased significantly with greater cannabis use in a dose-dependent manner. The associations between cannabis use and psychosis were 1.27 (95% CI 1.03-1.57) for lifetime cannabis use, 1.79 (95% CI 1.35-2.38) for lifetime cannabis abuse, and 3.69 (95% CI 2.49-5.47) for lifetime cannabis dependence. There was a similar dose-response relationship between the extent of cannabis use and schizotypal personality disorder (OR=2.02 for lifetime cannabis use, 95% CI 1.69-2.42; OR=2.83 for lifetime cannabis abuse, 95% CI 2.33-2.43; OR=7.32 for lifetime cannabis dependence, 95% CI 5.51-9.72). Likelihood of individual schizotypal features increased significantly with increased extent of cannabis use in a dose-dependent manner.Conclusion This is the first population-based study to examine the association between lifetime cannabis use, psychosis, and schizotypal personality traits. These results add to evidence that cannabis use may be a risk factor for psychosis liability.
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The paper gives a weak recommendation against cannabinoids in neuropathic pain, mainly because of negative results and risks of misuse, abuse, diversion, and long-term mental health harm in susceptible people.
“We provide a weak recommendation against the use of cannabinoids in neuropathic pain, mainly because of negative results, potential misuse, abuse, diversion and long term mental health risks particularly in susceptible individuals.66–71”
From Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis (2015) · cites this paper as [69]
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- Authors
- Davis, G. P., Compton, M. T., Wang, S., Levin, F. R., & Blanco, C.
- Affiliations
- Columbia University Irving Medical Center (US)
- George Washington University (US)
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 151
- Issue
- 1-3
- Pages
- 197-202
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC3877688
- OpenAlex
- W2167066160
- Cited by
- 95
- References
- 68
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 13 · 2016: 13 · 2015: 15 · 2014: 9
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism
- National Institute of Mental Health (R01MH082773, R01MH081011, MH076051, R01MH076051, MH081011, MH082773)
- National Institute on Drug Abuse (DA019606, R01DA023973, DA023200, R01DA019606, DA023973, K02DA023200, K24DA029647, DA007294, T32DA007294)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- cannabis use, psychosis
- MeSH terms
- Adolescent, Adult, Age Factors, Marijuana Abuse, Female, Health Surveys, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Retrospective Studies, Schizophrenia, Schizotypal Personality Disorder, Logistic Models, Young Adult
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