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Caloric restriction mimetics: towards a molecular definition

Madeo, Frank, Pietrocola, Federico, Eisenberg, Tobias, Kroemer, Guido·2014·Nature Reviews Drug Discovery
DOI 10.1038/nrd4391
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Abstract

Caloric restriction, be it constant or intermittent, is reputed to have health-promoting and lifespan-extending effects. Caloric restriction mimetics (CRMs) are compounds that mimic the biochemical and functional effects of caloric restriction. In this Opinion article, we propose a unifying definition of CRMs as compounds that stimulate autophagy by favouring the deacetylation of cellular proteins. This deacetylation process can be achieved by three classes of compounds that deplete acetyl coenzyme A (AcCoA; the sole donor of acetyl groups), that inhibit acetyl transferases (a group of enzymes that acetylate lysine residues in an array of proteins) or that stimulate the activity of deacetylases and hence reverse the action of acetyl transferases. A unifying definition of CRMs will be important for the continued development of this class of therapeutic agents.

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  • S-nitrosylation, the covalent binding of nitric oxide to specific cysteine residues, is a mechanism through which autophagy-related proteins are regulated.

    “Another mechanism through which autophagy-related proteins are regulated is by means of S-nitrosylation, the covalent binding of nitric oxide (NO) to specific cysteine residues [1003].”

    From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [1003]

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Metadata

Authors
Madeo, F., Pietrocola, F., Eisenberg, T., & Kroemer, G.
Venue
Nature Reviews Drug Discovery
Publisher
Springer Science and Business Media LLC
Published
2014-09-12
Volume
13
Issue
10
Pages
727-740
ISSN
  • 1474-1776
  • 1474-1784
DOI
10.1038/nrd4391
Cited by
245
References
36
Language
en
Licence

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