The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Exosomes and their roles in immune regulation and cancer
Open accessAbstract
Exosomes, a subset of extracellular vesicles (EVs), function as a mode of intercellular communication and molecular transfer. Exosomes facilitate the direct extracellular transfer of proteins, lipids, and miRNA/mRNA/DNAs between cells in vitro and in vivo. The immunological activities of exosomes affect immunoregulation mechanisms including modulating antigen presentation, immune activation, immune suppression, immune surveillance, and intercellular communication. Besides immune cells, cancer cells secrete immunologically active exosomes that influence both physiological and pathological processes. The observation that exosomes isolated from immune cells such as dendritic cells (DCs) modulate the immune response has enforced the way these membranous vesicles are being considered as potential immunotherapeutic reagents. Indeed, tumour- and immune cell-derived exosomes have been shown to carry tumour antigens and promote immunity, leading to eradication of established tumours by CD8(+) T cells and CD4(+) T cells, as well as directly suppressing tumour growth and resistance to malignant tumour development. Further understanding of these areas of exosome biology, and especially of molecular mechanisms involved in immune cell targeting, interaction and manipulation, is likely to provide significant insights into immunorecognition and therapeutic intervention. Here, we review the emerging roles of exosomes in immune regulation and the therapeutic potential in cancer.
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Cites
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Cited by
Exosomes: biogenesis, biologic function and clinical potential
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Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy
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Metadata
- Authors
- Greening, D. W., Gopal, S. K., Xu, R., Simpson, R. J., & Chen, W.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 40
- Pages
- 72-81
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2091868933
- Cited by
- 597
- References
- 11
- FWCI
- 18.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Greening, D. W., Gopal, S. K., Xu, R., Simpson, R. J., & Chen, W. (2015). Exosomes and their roles in immune regulation and cancer. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2015.02.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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