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Sleep disturbance in mild to moderate Alzheimer’s disease
Abstract
Background and purpose To determine the prevalence of sleep disturbance in a memory clinic population of Alzheimer's disease (AD) patients and identify its clinical correlates. Patients and methods Data from 215 attendees at a memory clinic, who were diagnosed with Alzheimer's disease, were examined. This included data from cognitive, functional and neuropsychological assessments. Sleep disturbance was determined using the question about diurnal rhythm disturbance on the BEHAVE-AD questionnaire. Two groups, with and without sleep disturbance, were compared. Group differences were analysed using univariate analysis and stepwise logistic regression analysis. Results The prevalence of sleep disturbance in this sample was 24.5%. The BEHAVE-AD 'aggressiveness' (P=0.009) and 'global rating' (P=0.029) (a measure of global impact of behavioural disturbance) were found to be significant predictors of sleep disturbance in AD. Conclusions Sleep disturbance in AD is associated with other behavioural symptoms, notably aggressiveness. Sleep disturbance in AD has significant impact on the patient and/or caregiver. Consideration of co-morbid behavioural symptoms may aid the clinician in choosing a suitable treatment for sleep disturbance in AD.
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For 25-40% of patients with mild to moderate AD who suffer from excessive daytime somnolence, daytime administration of ChEi can help consolidate sleep-wake rhythms by directly promoting daytime wakefulness.
“for 25-40% of patients with mild to moderate AD who suffer from excessive daytime somnolence, daytime administration of ChEi can help consolidate sleep-wake rhythms by directly promoting daytime wakefulness [34, 35]”
From Long-Term Trazodone Use and Cognition: A Potential Therapeutic Role for Slow-Wave Sleep Enhancers (2019) · cites this paper as [35]
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Metadata
- Authors
- MORAN, M., LYNCH, C., WALSH, C., COEN, R., COAKLEY, D., & LAWLOR, B.
- Affiliations
- St. James's Hospital (IE)
- Corresponding author
- MORAN, M
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 6
- Issue
- 4
- Pages
- 347-352
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W2081103834
- Cited by
- 346
- References
- 5
- Citations by year
- 2026: 17 · 2025: 16 · 2024: 22 · 2023: 31 · 2022: 25 · 2021: 27 · 2020: 33 · 2019: 31 · 2018: 27 · 2017: 18 · 2016: 23 · 2015: 11 · 2014: 12 · 2013: 8 · 2012: 13
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep disorders, Alzheimer's disease, behavioural symptoms, aggression, prevalence, memory clinic patients, caregiver burden
- MeSH terms
- Aged, Alzheimer Disease, Cognition Disorders, Female, Humans, Male, Neuropsychological Tests, Severity of Illness Index, Sleep Wake Disorders, Prevalence, Caregivers, Cost of Illness
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