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Cited by 327Sleep and Work-Related FatigueSleep and Wakefulness ResearchSleep and related disorders

The effects of sleep deprivation on symptoms of psychopathology in healthy adults

Kahn-Greene, Ellen T., Killgore, Desiree B., Kamimori, Gary H., Balkin, Thomas J., Killgore, William D.S.·2007·Sleep Medicine
DOI 10.1016/j.sleep.2006.08.007
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Abstract

Background Sleep loss leads to temporary changes in mood and cognition, and is associated with reduced cerebral metabolism within the prefrontal cortex, similar to findings observed in some psychiatric disorders. However, the extent to which sleep deprivation may be associated with the emergence of clinical symptoms of psychopathology in healthy normal individuals is not clear. Methods The Personality Assessment Inventory (PAI) was administered to 25 healthy adults at rested baseline and again after 56h of continuous wakefulness. Results Comparisons showed a significant global increase in PAI psychopathology scores from baseline to sleep-deprived sessions, particularly for somatic complaints, anxiety, depression, and paranoia. Mean elevations for the clinical scales remained within normal limits, however. In contrast, sleep loss was not associated with significant changes in anxiety-related disorders, manic symptoms, borderline, schizophrenic, or antisocial features. Conclusions Two nights without sleep may lead to a sub-clinical increase in self-reported affective symptoms of psychopathology while having little effect on symptoms of thought disorder, psychotic processes, or behavioral dysregulation. These data suggest that sleep loss may be differentially disruptive to regions of the brain involved in affective regulation and may, therefore, serve as a model for understanding the brain dysfunction associated with affective psychopathology.

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  • Following 56 h of sleep deprivation in 25 non-clinical volunteers, increases were observed in the anxiety, depression and paranoia factors of the Personality Assessment Inventory, but not in 'manic related symptoms' or 'schizophrenia symptoms' factors.

    “Kahn-Greene, Killgore, Kamimori, Balkin, and Killgore (2007) deprived 25 non-clinical volunteers of sleep for 56 h, administering the Personality Assessment Inventory (PAI; Morey, 1991) at baseline and after sleep deprivation. Following sleep deprivation, increases were observed in the anxiety, depression and paranoia factors, but not in ‘manic related symptoms’ or ‘schizophrenia symptoms’ factors”

    From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Kahn-Greene et al., 2007

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Authors
Kahn-Greene, E. T., Killgore, D. B., Kamimori, G. H., Balkin, T. J., & Killgore, W. D. S.
Affiliations
Walter Reed Army Institute of Research (US)
ORCID
Venue
Sleep Medicine
Publisher
Elsevier BV
Published
2007-04
Volume
8
Issue
3
Pages
215-221
ISSN
1389-9457 (ISSN-L)
DOI
10.1016/j.sleep.2006.08.007
OpenAlex
W2077875845
Cited by
327
References
9
Citations by year
2026: 6 · 2025: 16 · 2024: 11 · 2023: 13 · 2022: 23 · 2021: 28 · 2020: 18 · 2019: 27 · 2018: 17 · 2017: 23 · 2016: 15 · 2015: 24 · 2014: 26 · 2013: 23 · 2012: 16
FWCI
14.58
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Sleep Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
sleep deprivation, psychopathology, Personality Assessment Inventory, anxiety, depression, paranoia, somatic symptoms, emotion regulation, prefrontal cortex, thought disorder, healthy adults
MeSH terms
Adult, Anxiety Disorders, Depressive Disorder, Female, Humans, Male, Paranoid Disorders, Personality Inventory, Psychopathology, Risk Factors, Sleep Deprivation, Somatoform Disorders

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