Neural basis of alertness and cognitive performance impairments during sleepiness II. Effects of 48 and 72 h of sleep deprivation on waking human regional brain activity
Abstract
Sleep deprivation impairs alertness and cognitive performance, and these deficits suggest decreases in brain activity and function, particularly in the prefrontal cortex, a region subserving alertness, attention, and higher-order cognitive processes and in the thalamus, a subcortical structure involved in alertness and attention. To substantiate this premise, we characterized the effects of 24, 48, and 72 h of progressive sleep deprivation on brain activity by assessing regional cerebral metabolic rate for glucose (CMRglu) during complex cognitive task performance in 17 young, normal, healthy male volunteers using positron emission tomography (PET) and l8Fluoro-2-deoxyglucose (18FDG). The results of prolonged sleep deprivation, 48 and 72 h, are reported here. Compared to rested baseline (RB), global CMRglu decreased by 6% at 48 and 72 h sleep deprivation (SD) and approximated the 8% decrease seen at 24 h SD. Absolute and relative regional CMRglu decreased at 48 and 72 h SD primarily in the prefrontal and parietal cortices and in the thalamus, the same areas that showed decreases at 24 h SD. Compared to 24 h SD, relative regional CMRglu decreased further in the prefrontal cortex and dorsal thalamus at 48 and 72 h, and at 72 h SD in a limited area of medial visual cortex. Relative regional CMRglu increased in lateral superior occipital cortices, lingual and fusiform gyri, anterior cerebellum, and in primary and supplementary motor cortices at 48 and 72 h SD, indicating a rebound CMRglu activity response from 24 h SD. Polysomnographic monitoring confirmed that subjects were awake. Behavioral outcomes showed continuing decreases in alertness, cognitive performance, and saccadic velocity (a measure of oculomotor response) with prolonged sleep deprivation. Progressive decreases in relative CMRglu values in prefrontal, thalamic, and primary visual areas were correlated positively with the impairments in cognitive performance and saccadic velocity across the 72 h sleep deprivation period. Relative thalamic activity was also correlated with the alterations in alertness. The prefrontal and thalamic regions were positively correlated, suggesting that sleep deprivation impacted these areas together as a functional network.We propose that the decreases in CMRglu induced in the prefrontal-thalamic network by prolonged sleep deprivation underlie the decline in alertness and cognitive performance and signify the brain’s involuntary progression toward sleep onset, while the increases in visual and motor areas express the brain’s exertion of voluntary control to remain awake and perform. This exertion of voluntary control is manifest in increased subject effort and physical movement, and the recruitment of additional brain regions may reflect an attempt to sustain alertness and cognitive performance despite a continuing decline in prefrontal-thalamic activity. Our findings provide support for the notion of a specific sensitivity of the prefrontal cortex to, and a pivotal role of the thalamus in, sleepiness.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PET studies of sleep deprivation have consistently reported significant reductions in metabolic rates in the thalamic, parietal, and prefrontal regions after sleep loss, which correlated with declines of cognitive performance and alertness.
“PET studies of sleep deprivation have consistently reported significant reductions in metabolic rates in the thalamic, parietal, and prefrontal regions after sleep loss, which correlated with declines of cognitive performance and alertness.186–189”
From Circadian rhythms, sleep deprivation, and human performance (2013) · cites this paper as [189]
Cited by
Sorted by citations
<i>Sleep Deprivation and Vigilant Attention</i>
Lim, J., & Dinges, D. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.002 · Cited by 1,213 · see citing works
Overnight therapy? The role of sleep in emotional brain processing
Walker, M. P., & van der Helm, E. (2009) · Psychological Bulletin · doi:10.1037/a0016570 · Cited by 1,087 · see citing works
Fullagar, H. H. K., Skorski, S., Duffield, R., Hammes, D., Coutts, A. J., & Meyer, T. (2014) · Sports Medicine · doi:10.1007/s40279-014-0260-0 · Cited by 987 · see citing works
Impaired decision making following 49 h of sleep deprivation
Killgore, W., Balkin, T., & Wesensten, N. (2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00487.x · Cited by 571 · see citing works
The neurocognitive consequences of sleep restriction: A meta-analytic review
Lowe, C. J., Safati, A., & Hall, P. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.010 · Cited by 520 · see citing works
Circadian rhythms, sleep deprivation, and human performance
Goel, N., Basner, M., Rao, H., & Dinges, D. F. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00007-5 · Cited by 400 · see citing works
The effects of sleep deprivation on symptoms of psychopathology in healthy adults
Kahn-Greene, E. T., Killgore, D. B., Kamimori, G. H., Balkin, T. J., & Killgore, W. D. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.08.007 · Cited by 327 · see citing works
Relationships between affect, vigilance, and sleepiness following sleep deprivation
Franzen, P. L., Siegle, G. J., & Buysse, D. J. (2008) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00635.x · Cited by 312 · see citing works
A role for REM sleep in recalibrating the sensitivity of the human brain to specific emotions
Gujar, N., McDonald, S. A., Nishida, M., & Walker, M. P. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq064 · Cited by 276 · see citing works
Effects of caffeine on sleep quality and daytime functioning
O’Callaghan, F., Muurlink, O. T., & Reid, N. (2018) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s156404 · Cited by 250 · see citing works
The effects of 53 hours of sleep deprivation on moral judgment
Killgore, W. D. S., Killgore, D. B., Day, L. M., Li, C., Kamimori, G. H., & Balkin, T. J. (2007) · SLEEP · doi:10.1093/sleep/30.3.345 · Cited by 225 · see citing works
Sleep deprivation and neurobehavioral dynamics
Basner, M., Rao, H., Goel, N., & Dinges, D. F. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.02.008 · Cited by 192 · see citing works
Dawson, D. E., Searle, A., & Paterson, J. L. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.03.003 · Cited by 198 · see citing works
Neurophysiological correlates of sleepiness: a combined TMS and EEG study
De Gennaro, L., Marzano, C., Veniero, D., Moroni, F., Fratello, F., Curcio, G., Ferrara, M., Ferlazzo, F., Novelli, L., Concetta Pellicciari, M., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.013 · Cited by 147 · see citing works
Neurobiological Consequences of Sleep Deprivation
Alkadhi, K. A., Zagaar, M. A., Alhaider, I. A., Salim, S., & Aleisa, A. M. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311030001 · Cited by 121 · see citing works
Effects of 24-h and 36-h sleep deprivation on human postural control and adaptation
Patel, M., Gomez, S., Berg, S., Almbladh, P., Lindblad, J., Petersen, H., Magnusson, M., Johansson, R., & Fransson, P.-A. (2007) · Experimental Brain Research · doi:10.1007/s00221-007-1143-5 · Cited by 118 · see citing works
Neuroimaging in sleep medicine
Dang‐Vu, T. T., Desseilles, M., Petit, D., Mazza, S., Montplaisir, J. Y., & Maquet, P. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.006 · Cited by 119 · see citing works
Kenney, S. R., Lac, A., LaBrie, J. W., Hummer, & Pham, A. (2013) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2013.74.841 · Cited by 110 · see citing works
Morning-evening variation in human brain metabolism and memory circuits
Shannon, B., Dosenbach, R. A. T., Su, Y., Vlassenko, A. G., Larson‐Prior, L. J., Nolan, T. S., Snyder, A. Z., & Raichle, M. E. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00651.2012 · Cited by 102 · see citing works
Sleep deprivation disrupts prepulse inhibition and induces psychosis-like symptoms in healthy humans
Petrovsky, N., Ettinger, U., Hill, A., Frenzel, L., Meyhofer, I., Wagner, M., Backhaus, J., & Kumari, V. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0904-14.2014 · Cited by 102 · see citing works
Buysse, D. J., Nofzinger, E. A., Germain, A., Meltzer, C. C., Wood, A., Ombao, H., Kupfer, D. J., & Moore, R. Y. (2004) · SLEEP · doi:10.1093/sleep/27.7.1245 · Cited by 98 · see citing works
KILLGORE, W. D. S., KAMIMORI, G. H., & BALKIN, T. J. (2011) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00893.x · Cited by 90 · see citing works
Neuroimaging and sleep medicine
Nofzinger, E. A. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.07.003 · Cited by 80 · see citing works
Odor identification accuracy declines following 24 h of sleep deprivation
Killgore, W. D. S., & McBride, S. (2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00502.x · Cited by 78 · see citing works
Frequency-Dependent Changes of Local Resting Oscillations in Sleep-Deprived Brain
Gao, L., Bai, L., Zhang, Y., Dai, X., Rana, N., Min, Y.-J., Zhou, F., Niu, C., Dun, W., Gong, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120323 · Cited by 78 · see citing works
Poudel, G. R., Innes, C., & Jones, R. D. (2012) · SLEEP · doi:10.5665/sleep.1994 · Cited by 75 · see citing works
Rest, Zest, and My Innovative Best: Sleep and Mood as Drivers of Entrepreneurs’ Innovative Behavior
Williamson, A. J., Battisti, M., Leatherbee, M., & Gish, J. J. (2018) · Entrepreneurship Theory and Practice · doi:10.1177/1042258718798630 · Cited by 69 · see citing works
Chronic Low Quality Sleep Impairs Postural Control in Healthy Adults
Furtado, F., Gonçalves, B. D. S. B., Abranches, I. L. L., Abrantes, A. F., & Forner‐Cordero, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163310 · Cited by 72 · see citing works
Ma, J., Yj, Y., Ma, R.-M., Li, J.-Q., Wang, T., Li, X.-J., Han, W.-Q., Hu, W.-D., & Zhang, Z.-M. (2009) · Journal of International Medical Research · doi:10.1177/147323000903700506 · Cited by 70 · see citing works
Volkow, N. D., Tomasi, D. G., Wang, G., Telang, F., Fowler, J. S., Wang, R. L., Logan, J., Wong, C., Jayne, M. C., & Swanson, J. M. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.003 · Cited by 68 · see citing works
Effects of proprioceptive vibratory stimulation on body movement at 24 and 36 h of sleep deprivation
Gomez, S., Patel, M., Berg, S., Magnusson, M., Johansson, R., & Fransson, P.-A. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.10.058 · Cited by 69 · see citing works
Co-modulatory spectral changes in independent brain processes are correlated with task performance
Chuang, S.-W., Ko, L., Lin, Y., Huang, R., Jung, T., & Lin, C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.05.035 · Cited by 63 · see citing works
The trait of Introversion–Extraversion predicts vulnerability to sleep deprivation
Killgore, W. D. S., Richards, J., Killgore, D. B., Kamimori, G. H., & Balkin, T. J. (2007) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2007.00611.x · Cited by 63 · see citing works
Improving the saccade peak velocity measurement for detecting fatigue
Hirvonen, K., Puttonen, S., Gould, K. S., Korpela, J., Koefoed, V. F., & Müller, K. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.01.010 · Cited by 63 · see citing works
Felice, A. D., Fiaschi, A., Bongiovanni, G., Savazzi, S., & Manganotti, P. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.05.015 · Cited by 54 · see citing works
Lewandowska, K., Małkiewicz, M. A., Siemiński, M., Cubała, W. J., Winklewski, P. J., & Mędrzycka-Dąbrowska, W. A. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.01.019 · Cited by 51 · see citing works
Immediate error correction process following sleep deprivation
Hsieh, S., Cheng, I. C., & Tsai, L. (2007) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2007.00583.x · Cited by 53 · see citing works
Voldsbekk, I., Groote, I. R., Zak, N., Roelfs, D., Geier, O. M., Due‐Tønnessen, P., Løkken, L.-L., Strømstad, M., Blakstvedt, T. Y., Kuiper, Y. S., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117540 · Cited by 44 · see citing works
Effects of Shift Work on the Postural and Psychomotor Performance of Night Workers
Narciso, F. V., Barela, J. Â., Aguiar, S. A., Carvalho, A. N. S., Tufik, S., & de Mello, M. T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151609 · Cited by 41 · see citing works
Meyhöfer, I., Kumari, V., Hill, A., Petrovsky, N., & Ettinger, U. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116675511 · Cited by 34 · see citing works
Poudel, G. R., Innes, C., & Jones, R. D. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.03.054 · Cited by 31 · see citing works
OLFACTORY DECREMENTS AS A FUNCTION OF TWO NIGHTS OF SLEEP DEPRIVATION
McBride, S., Balkin, T. J., Kamimori, G. H., & Killgore, W. D. S. (2006) · Journal of Sensory Studies · doi:10.1111/j.1745-459x.2006.00080.x · Cited by 28 · see citing works
Yu, M., Kautz, M. A., Thomas, M., Johnson, D. E., Hotchkiss, E. R., & Russo, M. B. (2007) · Ophthalmic and Physiological Optics · doi:10.1111/j.1475-1313.2006.00450.x · Cited by 26 · see citing works
Self-citationWang, Y., Dai, C., Shao, Y., Wang, C., & Zhou, Q. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113674 · Cited by 24 · see citing works
Short-term sleep deprivation increases intrinsic excitability of prefrontal cortical neurons
Yan, J. Y., Li, J., Xie, M., Zhang, D., Qi, A., Hu, B., Huang, W. Y., Xia, J., & Hu, Z. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.032 · Cited by 26 · see citing works
Bougard, C., & Davenne, D. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1948-6 · Cited by 25 · see citing works
Increased prefrontal event-related current density after sleep deprivation
Szelenberger, W., Piotrowski, T., & browska, A. D. (2005) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2005-1536 · Cited by 25 · see citing works
Ivanov, I., Miraglia, B., Prodanova, D., & Newcorn, J. H. (2024) · Journal of Attention Disorders · doi:10.1177/10870547241232313 · Cited by 21 · see citing works
Selective modulations of attentional asymmetries after sleep deprivation.
Schmitz, R., Deliens, G., Mary, A., Urbain, C., & Peigneux, P. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.08.009 · Cited by 21 · see citing works
An evaluation and comparison of commercial driver sleepiness detection technology: a rapid review
Cori, J., Manousakis, J., Koppel, S., Ferguson, S., Sargent, C., Howard, M., & Anderson, C. (2021) · Physiological Measurement · doi:10.1088/1361-6579/abfbb8 · Cited by 18 · see citing works
Alkozei, A., Haack, M., Skalamera, J., Smith, R. S., Satterfield, B. C., Raikes, A. C., & Killgore, W. D. S. (2018) · Sleep Health · doi:10.1016/j.sleh.2018.07.003 · Cited by 22 · see citing works
Khoo, S. Y., Lai, W. H., On, S. H., On, Y. Y., Bujang, M. A., Law, W. C., Ng, B. H. S., Fong, A. Y. Y., & Ting, A. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-67902-0 · Cited by 21 · see citing works
Helfer, B., Bozhilova, N. S., Cooper, R. E., Douzenis, J. I., Maltezos, S., & Asherson, P. J. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2020.28 · Cited by 20 · see citing works
Electrodermal lability as an indicator for subjective sleepiness during total sleep deprivation
Michael, L., Paßmann, S., & BECKER, R. (2011) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2011.00984.x · Cited by 21 · see citing works
Shen, H., Xu, H., Wang, L., Lei, Y., Yang, L., Zhang, P., Qin, J., Zeng, L., Zhou, Z., Zheng, Y., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23693 · Cited by 20 · see citing works
Sleepiness, attention and risk of accidents in powered two-wheelers
Bougard, C., Davenne, D., Espié, S., Moussay, S., & Léger, D. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.01.006 · Cited by 20 · see citing works
Sleep deprivation and implications for recognition and perception of facial emotions
de Almondes, K. M., Júnior, F. W. N. H., & Alves, N. T. (2015) · Sleep and Biological Rhythms · doi:10.1007/s41105-015-0029-3 · Cited by 20 · see citing works
Alertness function of thalamus in conflict adaptation
Wang, X., Zhao, X., Xue, G., & Chen, A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.048 · Cited by 17 · see citing works
Robbins, R., & Quan, S. F. (2024) · NEJM Evidence · doi:10.1056/evidra2300269 · Cited by 9 · see citing works
The effects of sleep deprivation on risky decision making
Wei, X., Ma, J., Liu, S., Li, S., Shi, S., Guo, X., & Liu, Z. (2024) · Psychonomic Bulletin & Review · doi:10.3758/s13423-024-02549-6 · Cited by 15 · see citing works
Thomasson, J., Canini, F., Poly‐Thomasson, B., Trousselard, M., Granon, S., & Chauveau, F. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.08.431 · Cited by 13 · see citing works
Sex moderates the effects of total sleep deprivation and sleep restriction on risk preference
Lim, J. Y. L., Boardman, J. M., Dyche, J., Anderson, C., Dickinson, D. L., & Drummond, S. P. A. (2022) · SLEEP · doi:10.1093/sleep/zsac120 · Cited by 12 · see citing works
Sleep Loss, Daytime Sleepiness, and Neurobehavioral Performance among Adolescents: A Field Study
Tzischinsky, O., & Barel, E. (2022) · Clocks & Sleep · doi:10.3390/clockssleep4010015 · Cited by 10 · see citing works
What Brain Imaging Reveals About Sleep Generation and Maintenance
Nofzinger, E. A., & Maquet, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00012-x · Cited by 11 · see citing works
Sack, B., Broer, K., & Anders, S. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.10.035 · Cited by 10 · see citing works
Killgore, W., Killgore, D. B., Mcbride, S. A., Kamimori, G., & Balkin, T. (2008) · Journal of Sensory Studies · doi:10.1111/j.1745-459x.2007.00139.x · Cited by 9 · see citing works
Good daily habits during the early stages of life determine success throughout life
Kohyama, J. (2016) · Sleep Science · doi:10.1016/j.slsci.2016.09.002 · Cited by 8 · see citing works
Lin, C., Sun, J., Lin, C.-P., Chung, C., & Chien, W. (2020) · Alcohol · doi:10.1016/j.alcohol.2020.08.008 · Cited by 7 · see citing works
Controlled Attention and Sleep Deprivation: Adding a Self-Regulation Approach?
Pilcher, J. J., Geldhauser, H. A., Beeco, J. A., & Lindquist, T. A. (2013) · International Journal of Psychological Studies · doi:10.5539/ijps.v5n3p71 · Cited by 6 · see citing works
Faiola, E., Meyhöfer, I., Steffens, M., Kasparbauer, A., Kumari, V., & Ettinger, U. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.10.033 · Cited by 6 · see citing works
The Effect of Thirty-Six Hour Total Sleep Deprivation on Spatial Cognition and Alertness
Feng, W., Sun, R., & Zhang, K. (2018) · Lecture notes in computer science · doi:10.1007/978-3-319-91122-9_11 · Cited by 3 · see citing works
What Brain Imaging Reveals about Sleep Generation and Maintenance
Nofzinger, E. A., & Maquet, P. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6645-3.00018-9 · Cited by 3 · see citing works
Acute sleep deprivation in humans
Casale, C. E., Brieva, T. E., Yamazaki, E. M., Antler, C. A., & Goel, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00005-0 · Cited by 3 · see citing works
Sleep, gut microbiota, and mind-body medicine
Das, M., Muralitharan, G., Saini, S., & Patra, S. (2025) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2025.100128 · Cited by 2 · see citing works
Kothare, S. V., & Kaleyias, J. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511762697.026 · Cited by 3 · see citing works
Pristya, A. U., & Widyaningsih, T. D. (2019) · Advances in Food Science Sustainable Agriculture and Agroindustrial Engineering · doi:10.21776/ub.jtp.2019.002.02.2 · Cited by 1 · see citing works
The role of sleep deprivation in physiological system dysfunctions
Uslu, H., & Uslu, G. A. (2023) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2023.20.3.2412 · Cited by 1 · see citing works
Sleep/Wake Disturbances in Mild Traumatic Brain Injury Patients
Russo, M. B., Alphonso, A. L., & Murphy, I. C. (2012) · Springer eBooks · doi:10.1007/978-0-387-87887-4_7 · Cited by 1 · see citing works
De la gestion du risque fatigue à la prise de décision collaborative
Hauret, D., Mollard, R., & Wolff, M. (2012) · doi:10.1145/2652574.2653408 · Cited by 1 · see citing works
Luo, M., Mei, R., Li, J., et al. (2013) · Lecture notes in computer science · doi:10.1007/978-3-642-39354-9_20 · Cited by 1 · see citing works
Assessment of the association between sleep disturbance and physical performance in adolescent girls
Guembri, M. A., Racil, G., Dhouibi, M.-A., Marghli, Y. H., Coquart, J. B., Aouichaoui, C., & Souissi, N. (2023) · Biological Rhythm Research · doi:10.1080/09291016.2023.2225406 · Cited by 1 · see citing works
How Sleep Quality Affects Postural Control?
Karahan, M., Pehli̇van, M., Uluçam, E., Seyaz, M., & Donmez, D. (2024) · Bezmialem Science · doi:10.14235/bas.galenos.2023.24482 · Cited by 1 · see citing works
Imaging Sleep and Sleep Deprivation
Dang‐Vu, T. T. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9087-6_4 · Cited by 1 · see citing works
Sleep/Wake Disturbances in Mild Traumatic Brain Injury Patients
Krainin, J., Morrison, A. A., & Russo, M. B. (2019) · Springer eBooks · doi:10.1007/978-3-030-22436-3_7 · Cited by 1 · see citing works
Muza, R. (2018) · Springer eBooks · doi:10.1007/978-3-642-54836-9_1 · Cited by 1 · see citing works
Sleep Loss and Risk-taking Behavior
Womack, S. D. (2012) · doi:10.12794/metadc149686
Nofzinger, E. A. (2008) · Springer eBooks · doi:10.1007/978-1-4419-0854-4_3
Inocente, C. O., Inocente, J. J., Inocente, N. J., & Reimão, R. (2011) · Psicologia Saúde & Doenças · doi:10.15309/11psd120103 · Cited by 1 · see citing works
Neuroimaging in Normal and Abnormal Sleep
Dang‐Vu, T. T., O’Byrne, J., Zhang, V., Arcelin, A., Schwartz, S., Peigneux, P., Maquet, P., & Desseilles, M. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_21
Rao, S., & Anand, N. S. (2021) · Indian Journal of Physiology and Pharmacology · doi:10.25259/ijpp_160_2020
Ambient Darkness and Consumer Behavior
Vo, K. (2023) · doi:10.12794/metadc2179328
Mapping human sleep-state brain function with simultaneous EEG and neuroimaging: A systematic review
Pollatou, A., Tays, G. D., Skeiky, L., Coon, W. G., Scholl, C. A., Abad, N., Metzger, E., Marinelli, L., Ajala, A., Yeh, P., et al. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.122122 · Cited by 1 · see citing works
Neuroimagen en el sueño y en los trastornos del sueño
Desseilles, M., Dang‐Vu, T. T., Schwartz, S., Peigneux, P., & Maquet, P. (2011) · Elsevier eBooks · doi:10.1016/b978-84-8086-733-7.00015-2
- Authors
- Thomas, M. L., Sing, H. C., Belenky, G., Holcomb, H. H., Mayberg, H. S., Dannals, R. F., Wagner Jr., H. N., Thorne, D. R., Popp, K. A., Rowland, L. M., Welsh, A. B., Balwinski, S. M., & Redmond, D. P.
- Affiliations
- Walter Reed Army Institute of Research (US)
- University of Maryland, Baltimore (US)
- University of Toronto (CA)
- Johns Hopkins University (US)
- ORCID
- Venue
- Thalamus and Related Systems
- Publisher
- Cambridge University Press (CUP)
- Published
- 2003-08
- Volume
- 2
- Issue
- 03
- Pages
- 199
- ISSN
- 1472-9288 (ISSN-L)
- 1744-8107
- OpenAlex
- W2125494882
- Cited by
- 156
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 9 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 2 · 2013: 12 · 2012: 8
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thalamus & Related Systems (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- sleep deprivation, alertness, cognitive performance, regional cerebral glucose metabolism, prefrontal cortex, thalamus, dorsal thalamus, parietal cortex, saccadic velocity, oculomotor responses, sleepiness, complex cognitive tasks, 18F-FDG PET, polysomnography, attention deficits
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
