Associations between actigraphy-assessed sleep, inflammatory markers, and insulin resistance in the Midlife Development in the United States (MIDUS) study
Open accessAbstract
Background Disturbed sleep has been associated with increased insulin resistance and elevated inflammation. Although there is growing body of evidence that activation of inflammatory pathways plays a crucial role in the development of insulin resistance, the mediational model whereby sleep disturbances influence inflammation that drives insulin resistance has not been fully assessed in general population studies with objectively measured sleep. This study aimed to examine associations between objectively measured sleep, inflammatory markers, and insulin resistance simultaneously and in a mediational analysis, thereby offering insights into the possible causal model.Methods Cross-sectional data collected from 2004 to 2009 during the Midlife Development in the United States II biomarker project were used. The study population included 374 community-based participants (138 men and 236 women) who completed seven nights of wrist actigraphy. Multiple regressions controlling for age and statistically significant variables in univariate regressions were performed to evaluate the associations between actigraphy-assessed sleep measures, inflammatory cytokines, and insulin resistance.Results The regression models showed that in women, higher sleep onset latency (SOL) was associated with higher insulin resistance after controlling for age, smoking, obesity, diabetes, depression, and inflammatory cytokines. Higher SOL was also associated with higher interleukin (IL)-6 and C-reactive protein (CRP) levels in women, but no association was found in men. Using mediation models in women, the association between SOL and insulin resistance was partially explained by the indirect effect of inflammatory cytokines.Conclusion A combination of inflammation and other unidentified pathways may contribute to the relationship between disturbed sleep and glucose homeostasis.
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Actigraphy-measured sleep onset latency was linked with greater insulin resistance among men and women in univariate analyses.
“cross-sectional evidence in a sample subset from the Midlife Development in the United States II study indicated that actigraphy-measured sleep onset latency was linked with greater insulin resistance among men and women in univariate analyses.18”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [18]
When explored separately, the association between sleep onset latency and insulin resistance persisted for women but not men and was robust to inclusion of inflammatory markers, BMI, and depression.
“When this relationship was explored in men and women separately, the association persisted for women but not men and was robust to inclusion of additional covariates such as inflammatory markers, BMI, and depression.18”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [18]
Epidemiologic evidence shows that poor sleep quality promotes impairments in insulin and glucose metabolism.
“Although the data are less robust, epidemiologic evidence also shows that poor sleep quality promotes impairments in insulin and glucose metabolism.”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [18]
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- Authors
- Kim, T. H., Carroll, J. E., An, S. K., Seeman, T. E., Namkoong, K., & Lee, E.
- Affiliations
- Yonsei University (KR)
- University of California, Los Angeles (US)
- Corresponding author
- Lee, Eun
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 27-28
- Pages
- 72-79
- ISSN
- 1389-9457 (ISSN-L)
- PMC
- PMC5206915
- OpenAlex
- W2543767348
- Cited by
- 39
- References
- 43
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 2
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Research Foundation of Korea (NRF-2014S1A3A2044496)
- Korean Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HM15C0995)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- sleep disorders, insulin resistance, inflammatory cytokines, interleukin-6, C-reactive protein, sleep latency, mediation analysis, sex differences, glucose homeostasis, Midlife Development in the United States
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Homeostasis, Humans, Inflammation, Insulin Resistance, Male, Middle Aged, Regression Analysis, Sex Characteristics, Sleep, Time Factors, United States, Cohort Studies, Biomarkers, Cytokines, Actigraphy
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