Sleep loss activates cellular markers of inflammation: Sex differences
Open accessAbstract
Sleep disturbance is associated with inflammation and related disorders including cardiovascular disease, arthritis, and diabetes mellitus. Given sex differences in the prevalence of inflammatory disorders with stronger associations in females, this study was undertaken to test the effects of sleep loss on cellular mechanisms that contribute to proinflammatory cytokine activity. In 26 healthy adults (11 females; 15 males), monocyte intracellular proinflammatory cytokine production was repeatedly assessed at 08:00, 12:00, 16:00, 20:00, and 23:00h during a baseline period and after partial sleep deprivation (awake from 23:00 to 3.00h). In the morning after a night of sleep loss, monocyte production of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) differentially changed between the two sexes. Whereas both females and males showed a marked increase in the lipopolysaccharide (LPS) - stimulated production of IL-6 and TNF-alpha in the morning immediately after PSD, production of these cytokines during the early- and late evening was increased in the females as compared to decreases in the males. Sleep loss induces a functional alteration of monocyte proinflammatory cytokine responses with females showing greater cellular immune activation as compared to changes in males. These results have implications for understanding the role of sleep disturbance in the differential risk profile for inflammatory disorders between the sexes.
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Genes downregulated after CBT-I included transcripts involved in inflammation, while upregulated genes included transcripts involved in IFN and antibody responses.
“Using a genome-wide transcriptional profiling approach, genes that were downregulated after CBT-I included transcripts involved in inflammation, while upregulated genes included transcripts involved in IFN and antibody responses (257).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [257]
The percentages of monocytes producing TNF alone or in combination with IL-6 were lower 2 mo post-treatment, but not during later follow-up time points.
“Furthermore, the percentages of monocytes producing TNF alone or in combination with IL-6 were lower 2 mo post-treatment (257), but not during later follow-up time points.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [257]
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- Authors
- Irwin, M. R., Carrillo, C., & Olmstead, R.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Irwin, Michael R.
- ORCID
- Irwin, Michael R.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 24
- Issue
- 1
- Pages
- 54-57
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC2787978
- OpenAlex
- W2001816007
- Cited by
- 287
- References
- 32
- Citations by year
- 2026: 13 · 2025: 26 · 2024: 30 · 2023: 18 · 2022: 17 · 2021: 14 · 2020: 20 · 2019: 21 · 2018: 8 · 2017: 7 · 2016: 17 · 2015: 23 · 2014: 21 · 2013: 18 · 2012: 15
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG 026364, R01AG026364, R01AG034588, P30AG028748)
- National Heart, Lung, and Blood Institute (HL 079955, R01HL079955)
- National Institute of Mental Health (T32MH019925, T32 MH 19925)
- National Cancer Institute (R01CA116778, CA-10014152, CA-116778, R01CA119159)
- National Center for Research Resources (M01RR000865, RR00827, M01RR000827)
- Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep deprivation, sex differences, monocytes, inflammatory cytokines, interleukin-6, TNF-α, lipopolysaccharide stimulation, cellular immune activation, inflammation, circadian variation
- MeSH terms
- Adult, Female, Flow Cytometry, Humans, Inflammation, Lipopolysaccharides, Male, Psychiatric Status Rating Scales, Risk Factors, Sex Characteristics, Sleep Deprivation, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Toll-Like Receptor 4
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