The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans
Abstract
Components of the innate immune response, including neutrophils and macrophages, are the first line of defense against infections. Their role is to initiate an inflammatory response, phagocyte and kill pathogens, recruit natural killer cells (NK), and facilitate the maturation and migration of dendritic cells that will initiate the adaptive immune response. Extraordinary advances have been made in the last decade on the knowledge of the receptors and mechanisms used by cells of the innate immunity not only to sense and eliminate the pathogen but also to communicate each other and collaborate with cells of adaptive immunity to mount an effective immune response. The analysis of innate immunity in elderly humans has evidenced that aging has a profound impact on the phenotype and functions of these cells. Thus altered expression and/or function of innate immunity receptors and signal transduction leading to defective activation and decreased chemotaxis, phagocytosis and intracellular killing of pathogens have been described. The phenotype and function of NK cells from elderly individuals show significant changes that are compatible with remodeling of the different NK subsets, with a decrease in the CD56bright subpopulation and accumulation of the CD56dim cells, in particular those differentiated NK cells that co-express CD57, as well as a decreased expression of activating natural cytotoxicity receptors. These alterations can be responsible of the decreased production of cytokines and the lower per-cell cytotoxicity observed in the elderly. Considering the relevance of these cells in the initiation of the immune response, the possibility to reactivate the function of innate immune cells should be considered in order to improve the response to pathogens and to vaccination in the elderly.
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“which in turn could underlie the numerous age-related deficiencies observed in mature myeloid cells such as neutrophils and macrophages (25,26).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [25]
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Age-dependent dysregulation of innate immunity
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Metadata
- Authors
- Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T.
- Affiliations
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Universidad de Extremadura (ES)
- Université de Sherbrooke (CA)
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 24
- Issue
- 5
- Pages
- 331-341
- ISSN
- 1044-5323 (ISSN-L)
- OpenAlex
- W1971907346
- Cited by
- 567
- References
- 158
- Citations by year
- 2026: 26 · 2025: 36 · 2024: 27 · 2023: 44 · 2022: 48 · 2021: 50 · 2020: 49 · 2019: 49 · 2018: 47 · 2017: 35 · 2016: 41 · 2015: 33 · 2014: 40 · 2013: 36 · 2012: 4
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Université de Sherbrooke
- Ministerio de Ciencia e Innovación
- Junta de Extremadura
- Canadian Institutes of Health Research (106634, 106701)
- European Regional Development Fund
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- immunosenescence, innate immunity, aging, natural killer cells, NK cell subsets, CD57, natural cytotoxicity receptors, neutrophils, macrophages, innate immune receptors, phagocytosis, chemotaxis, cytokine production, older adults
- MeSH terms
- Animals, Dendritic Cells, Humans, Immunity, Innate, Neutrophils, Receptors, Immunologic, Cellular Senescence
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