Cited by 567Immune Response and InflammationImmune Cell Function and InteractionImmune responses and vaccinations

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Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

Solana, Rafael, Tarazona, Raquel, Gayoso, Inmaculada, Lesur, Olivier, Dupuis, Gilles, Fulop, Tamas·2012·Seminars in Immunology

DOI 10.1016/j.smim.2012.04.008

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Abstract

Components of the innate immune response, including neutrophils and macrophages, are the first line of defense against infections. Their role is to initiate an inflammatory response, phagocyte and kill pathogens, recruit natural killer cells (NK), and facilitate the maturation and migration of dendritic cells that will initiate the adaptive immune response. Extraordinary advances have been made in the last decade on the knowledge of the receptors and mechanisms used by cells of the innate immunity not only to sense and eliminate the pathogen but also to communicate each other and collaborate with cells of adaptive immunity to mount an effective immune response. The analysis of innate immunity in elderly humans has evidenced that aging has a profound impact on the phenotype and functions of these cells. Thus altered expression and/or function of innate immunity receptors and signal transduction leading to defective activation and decreased chemotaxis, phagocytosis and intracellular killing of pathogens have been described. The phenotype and function of NK cells from elderly individuals show significant changes that are compatible with remodeling of the different NK subsets, with a decrease in the CD56bright subpopulation and accumulation of the CD56dim cells, in particular those differentiated NK cells that co-express CD57, as well as a decreased expression of activating natural cytotoxicity receptors. These alterations can be responsible of the decreased production of cytokines and the lower per-cell cytotoxicity observed in the elderly. Considering the relevance of these cells in the initiation of the immune response, the possibility to reactivate the function of innate immune cells should be considered in order to improve the response to pathogens and to vaccination in the elderly.

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Authors: Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., & Fulop, T.
Affiliations: Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
Universidad de Extremadura (ES)
Université de Sherbrooke (CA)
ORCID: Solana, Rafael
Tarazona, Raquel
Gayoso, Inmaculada
Lesur, Olivier
Dupuis, Gilles
Venue: Seminars in Immunology
Publisher: Elsevier BV
Published: 2012-10
Volume: 24
Issue: 5
Pages: 331-341
ISSN: 1044-5323 (ISSN-L)
DOI: 10.1016/j.smim.2012.04.008
OpenAlex: W1971907346
Cited by: 567
References: 158
Citations by year: 2026: 26 · 2025: 36 · 2024: 27 · 2023: 44 · 2022: 48 · 2021: 50 · 2020: 49 · 2019: 49 · 2018: 47 · 2017: 35 · 2016: 41 · 2015: 33 · 2014: 40 · 2013: 36 · 2012: 4
FWCI: 3.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Université de Sherbrooke
Ministerio de Ciencia e Innovación
Junta de Extremadura
Canadian Institutes of Health Research (106634, 106701)
European Regional Development Fund
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: immunosenescence, innate immunity, aging, natural killer cells, NK cell subsets, CD57, natural cytotoxicity receptors, neutrophils, macrophages, innate immune receptors, phagocytosis, chemotaxis, cytokine production, older adults
MeSH terms: Animals, Dendritic Cells, Humans, Immunity, Innate, Neutrophils, Receptors, Immunologic, Cellular Senescence

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Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

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